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  • Chemotherapy  (1)
  • Cubic spline interpolation  (1)
  • Springer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Simultaneous determination of 5′-deoxy-5-fluorouridine, 5-fluorouracil and its main metabolites in body fluids by HPLC (1992)
    Springer
    Chromatographia 33 (1992), S. 413-417 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Fluoropyrimidine drugs ; Pharmacokinetics of doxifluridine ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A reversed phase high performance liquid chromatographic method has been developed for the simultaneous determination of the pro-drug 5′-deoxy-5-fluorouridine (5′-dFUR), its metabolite 5-fluorouracil (5-FU) and some fluorinated pyrimidines involved in the metabolic activation process of 5-FU. The method has been used to monitor the bioavailability of 5′-dFUR and 5-FU in patients undergoing anticancer chemotherapy. Serum sample treatment involves addition of internal standard (5-bromouracil), protein precipitation with saturated ammonium sulphate solution and liquid-liquid extraction with ethyl acetate-isopropanol (90 ∶ 10 v/v). Urine is simply diluted with mobile phase and injected. The average recovery from serum (at 0.5 μg/mL level) was 95.0%±1.4 for 5′-dFUR and 86.3%±3.5 for 5-FU. A linear response extending over four decades of concentration was observed. Detection limits in the low ng/ mL range were obtained using a 250 μL sample size and a 20 μL injection volume. Within-day and between-day coefficients of variation were below 4 and 10%, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02262320
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  • 2
    Electronic Resource
    Electronic Resource
    Kalman filter deconvolution after cubic splines background removal in the HPLC determination of Cr(III) and Al(III) as 8-hydroxyquinolines (1990)
    Springer
    Chromatographia 29 (1990), S. 269-274 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Kalman filter ; Cubic spline interpolation ; Al(III) and Cr(III)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A procedure for the simultaneous quantitation of Al(III) and Cr(III) ions by reversed-phase HPLC, after pre-column complexation with 8-hydroxyquinoline, is described. The deconvolution of the partially overlapped peaks was by the Kalman filter method which yielded accurate and precise results. Background removal from the chromatograms was by a new approach employing cubic splines as interpolators between the peak valleys. Finally, it is shown that the Kalman filter deconvolution, after subtraction of the background by cubic spline interpolation, allowed quantitation of Al(III) and Cr(III) down to 25 ppb for each metal. These concentrations were not detectable by conventional integration methods due to a very low signal-to-noise ratio.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02317917
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    Paper (German National Licenses)
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