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  • Articles  (2)
  • Werkzeugunterstützung  (1)
  • adenylyl cyclase  (1)
  • Chemistry
  • General Chemistry
  • Hemiporphycen
  • Photophysik
  • Springer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Die Praxis der Softwareentwicklung: Eine Erhebung (1999)
    Springer
    Informatik-Spektrum 22 (1999), S. 24-36 
    Details
    ISSN: 1432-122X
    Keywords: Schlüsselwörter Softwareentwicklungsprozeß ; Prozeßbewertung ; Prozeßverbesserung ; Beschreibungstechniken ; Werkzeugunterstützung ; Key words Software development process ; Process evaluation ; Process improvement ; Description techniques ; Tool support
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Summary Within the research consortium on software engineering FORSOFT, the software development processes currently practised by the consortium’s industrial partners were investigated into by interviews. This study evalu-ates the interview results and presents overall trends as well as requirements regarding process definition, description tech-niques, tool support, documentation, project management, and organization.
    Notes: Zusammenfassung Im Rahmen des Forschungsverbundes Software-Engineering wurden durch Interviews die derzeit bei den Industriepartnern des Forschungsverbundes praktizierten Softwareentwicklungsprozesse erfaßt. Diese Studie wertet die Ergebnisse der geführten Interviews aus und stellt übergreifende Trends und Anforderungen bezüglich Prozeßdefinition, Beschreibungstechniken, Werkzeugunterstützung, Dokumentation, Projektmanagement und Organisation vor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002870050121
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  • 2
    Electronic Resource
    Electronic Resource
    Down regulation of myocardial β1-adrenoceptor signal transduction system in pacing-induced failure in dogs with aortic stenosis-induced left ventricular hypertrophy (2000)
    Springer
    Molecular and cellular biochemistry 205 (2000), S. 67-73 
    Details
    ISSN: 1573-4919
    Keywords: cardiac hypertrophy ; heart failure ; beta-adrenoceptors ; adenylyl cyclase ; cyclic AMP ; dogs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract We recently demonstrated that rapid ventricular pacing caused cardiac failure (Failure) in dogs with aortic stenosis-induced left ventricular hypertrophy (Hypertrophy) and isoproterenol caused no significant increases in function, O2 consumption and intracellular cyclic AMP level in the failing hypertrophied hearts. We tested the hypothesis that alterations in the β1-adrenoceptor-signal transduction pathway would correlate with the reduced functional and metabolic responses to β-adrenergic stimulation during the transition from the compensated hypertrophy to failure. Pressure overload-induced left ventricular hypertrophy was created using aortic valve plication in 10 dogs over a 6-month period. Five months after aortic valve plication, congestive heart failure was induced in 5 dogs by rapid ventricular pacing at 240 bpm for 4 weeks. The density of myocardial β1-adrenoceptors (fmoles/mg membrane protein; fmoles/g wet tissue) was significantly reduced in the Failure dogs (176 ± 19; 755 ± 136) when compared to those of the Control (344 ± 51; 1,551 ± 203) and the Hypertrophy (298 ± 33; 1,721 ± 162) dogs. The receptor affinities were not significantly different among all groups. There was a small but significant decrease in the percentage of β1-adrenoceptors of the failing hypertrophied hearts (62 ± 3%) when compared to that of the hypertrophied hearts (77 ± 5%). The basal myocardial adenylyl cyclase activity (rmoles/mg protein/min) was significantly lower in the Failure dogs (45 ± 4) than in the Control (116 ± 14) and Hypertrophy (86 ± 6) dogs. The forskolin (0.1 mM)-stimulated adenylyl cyclase activity was also significantly lower in the Failure dogs (158 ± 17) than in the Control dogs (296 ± 35) and slightly lower than in the Hypertrophy dogs (215 ± 10). There were no significant differences in low Km cyclic AMP-phosphodiesterase activities among all groups. We conclude that down regulation of β1-adrenoceptors and reduced adenylyl cyclase activities contribute to the decreases in myocardial functions and β-adrenergic responses in the failing hypertrophied hearts induced by rapid ventricular pacing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007085027234
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