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  • Brain gangliosides  (1)
  • Teleost fish
  • Temperature
  • temperature adaptation
  • Springer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Changes in developmental profiles of brain gangliosides during ontogeny of a teleost fish (Sarotherodon mossambicus, Cichlidae) (1985)
    Springer
    Development genes and evolution 194 (1985), S. 166-172 
    Details
    ISSN: 1432-041X
    Keywords: Ontogeny ; Teleost fish ; Brain gangliosides ; Sialo-glycoproteins ; Sialic acid ; Sarotherodon mossambicus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Ontogenetic changes of brain ganglioside concentration and composition have been followed in the teleost fishSarotherodon mossambicus Cichlidae) from the 1st day post hatching to the adult stage, in order to correlate these with findings in higher vertebrates. During the developmental period from hatching to the transition to free swimming, which comes along with maximum rate of synaptogenesis, a sharp rise in the brain ganglioside content occurs, which is mainly due to the trisialoganglioside GT1b. In the following phase of myelination (characterized in birds and mammals by an increase in GM1, GM1′ and GM4) accretion of the novel and so far unidetified fraction (GM2) occurs, which is highly enriched in the brain stem. The results obtained are discussed with respect to gangliosides as useful biochemical markers for brain development and maturation in all vertebrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848317
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  • 2
    Electronic Resource
    Electronic Resource
    Gangliosides Affect Membrane-Channel Activities Dependent on Ambient Temperature (2000)
    Springer
    Cellular and molecular neurobiology 20 (2000), S. 579-590 
    Details
    ISSN: 1573-6830
    Keywords: bilayer ; alamethicin ; homoioviscosity ; gangliosides ; temperature adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 1. The functional properties of biological membranes depend on their molecular composition. In regard to this, charged glycosphingolipids play an outstanding role in the functional adaptation of membranes to different temperatures. 2. In order to shed some light on the respective functional properties of complex membraneous glycosphingolipids, the effects of altered temperatures (5–40°C) on planar lipid bilayers made from diphytanoylphosphatidylcholine (DPPC) and alamethicin as an ion channel was analyzed in the presence of either a sialoglycosphingolipid (less polar disialoganglioside GD1a or highly polar tetrasialoganglioside GQ1b) or phosphatidylserine (PS; as control). 3. Different to the control bilayers made from DPPC or DPPC + PS, the bilayers containing gangliosides had specific maxima in alamethicin conductance and stabile life times. Changes in pore-state conductances indicate structural effects based on an interaction of the large (negatively charged) ganglioside headgroups with the alamethicin pores. 4. The results concerning open time and closed time of channels seem to be based on the gangliosides changing the viscosity of the bilayer and possibly introducing phase transitions. 5. Thus, the findings suggest that gangliosides (1) directly affect channel molecules via their headgroups and (2) may additionally affect the fluidity of membranes in order to maintain membrane homeoviscosity in areas surrounding ion channels independent from the environmental temperature. 6. The effects of gangliosides may be of special interest in describing the ability of neuronal adaptation of vertebrates to temperature and more general regarding the functional adaptation of neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007063928449
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