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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Research in engineering design 5 (1993), S. 140-160 
    ISSN: 1435-6066
    Keywords: Design documentation ; Features ; Functional modeling ; Product modeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract This paper describes preliminary work toward the develoment of a framework and a system for modeling the “meta-physical” information of mechanical products. Meta-physical information is that information which describes the nature or reason for existence of objects in the physical product model. Such information includes product and feature functionality, design intent, relations, constraints and viewpoint-dependent definitions. This effort has resulted in an initial model structure and a prototype system. The product model consists of a meta-physical product model with attached physical product models containing, among other information, geometry, dimensions, tolerances, and features. The content and structure of the product model correspond directly to the information used and produced during the mechanical design process. The prototype system integrates a solid modeler, a feature modeler, a dimension and tolerance modeler, and a meta-physical modeler. This paper provides an overview of the meta-model structure, usage and potential.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1211
    Keywords: Key words Animal model ; Arthritis ; Autoimmune disease ; T-cell receptor polymorphism ; Transgenic mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Collagen type II-induced arthritis (CIA) develops in susceptible mouse strains after intradermal injections of type II collagen (CII) in complete Freund's adjuvant (CFA). Susceptibility to CIA in mice is linked to genes of the major histocompatibility complex (MHC). Although the SWR mouse has a susceptible MHC haplotype (H2 q ), it is resistant to CIA. SWR exhibits at least two known immunological defects: (1) it contains a germline deletion of about 50% of T-cell receptor (TCR) Vβ-chain gene segments, and (2) SWR is deficient in complement component C5. It has been shown that T cells that express TCRVα11.1 and TCRVβ8.2 play a substantial role in the pathogenesis of arthritis in the DBA/1 mouse (H2 q ). We generated SWR transgenic (tg) mice to determine whether the expression of pathogenic Vα11.1 and/or Vβ8.2 transgenes would confer arthritis susceptibility. Arthritis was induced in the SWR TCRαβ tg mice, but not in SWR TCRβ tg mice. To address the role of Vα11.1 in arthritis susceptibility, we examined the allelic polymorphisms of the Tcra-V11-gene subfamily members between the arthritis susceptible DBA/1 mouse and the arthritis-resistant SWR mouse strain. The amino acid sequences of the Vα11.1 alleles differ at two positions (codons 18 and 68). Accordingly, these two amino acid changes are sufficient to allow the production of pathogenic T cells in SWR mice. This is the first demonstration of the association of a particular Tcra-V allele and arthritis susceptibility in mice.
    Type of Medium: Electronic Resource
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