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  • Ac element  (1)
  • Hypertension  (1)
  • Hypocalcemia  (1)
  • Springer  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of acute changes in plasma calcium on adrenocortical secretory rates (1970)
    Springer
    Calcified tissue international 6 (1970), S. 220-226 
    Details
    ISSN: 1432-0827
    Keywords: Hypercalcemia ; Hypocalcemia ; Adrenal Cortex ; Hormones ; Secretion ; Calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Les augmentations en teneur du calcium plasmatique, provoquées par le gluconate de calcium, donnent des taux de sécrétions plus élevées du cortex surrénalien chez les chiens anesthésiés. L'hypocalcémie consécutive à l'action du EDTA n'a pas d'action sur ces sécrétions et l'hypophysectomie supprime l'augmentation des taux de sécrétion, observés chez l'animal entier hypercalcémique. Les mécanismes par lesquels le calcium peut affecter les sécrétions cortico-surrénaliennes sont envisagés en fonction des effects au niveau des différentes phases du système hypothalamo-hypophyso-cortico-surrénalien.
    Abstract: Zusammenfassung Durch Infusion von Calciumgluconat verursachte Erhöhungen des Plasmacalciumspiegels ergaben beim anaesthesierten Hund eine gesteigerte adrenocorticale Sekretion. Die Hypocalcämie, die auf Grund von EDTA-Infusion entstand, hatte keine sichtbare Wirkung auf das Ausmaß der adrenocorticalen Sekretion. Durch Hypophysektomie wurde die gesteigerte Sekretion, wie man sie beim hypercalcaemischen Tier findet, aufgehoben. Die Mechanismen, durch welche Calcium die adrenocorticale Sekretion beeinflussen kann, werden im Hinblick auf seine Wirkung an verschiedenen Stellen im hypothalamo-hypophysär-adrenocorticalen System besprochen.
    Notes: Abstract Increases in plasma calcium levels caused by the infusion of calcium gluconate resulted in enhanced adrenocortical secretory rates in anesthetized dogs. Hypocalcemia resulting from the infusion of EDTA had no discernible effect on adrenocortical secretory rates, and hypophysectomy abolished the rise in secretory rates noted in the hypercalcemic intact animals. The mechanisms by which calcium may effect adrenocortical secretion are discussed with respect to its effect at various sites in the hypothalamo-hypophyseal-adrenocortical system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02196202
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  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of lipid metabolism during antihypertensive treatment with nicardipine sr (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 225-227 
    Details
    ISSN: 1432-1041
    Keywords: Hypertension ; Hyperlipidaemia ; Nicardipine ; lipid metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The an tihypertensive and metabolic effects of oral nicardipine SR 40 mg b. i. d. have been studied in 18 (15 m, 3 f; age 52.7 y) hypertensives with mild hypercholesterolaemia, treated for 3 months after a 2 week period on placebo. An iv Fat Tolerance Test (FTT) was also performed in 8 patients following placebo, treatment with acute nicardipine 20 mg and chronic administration of nicardipine SR. There was a significant fall in BP from 160/97 on placebo to 147/87 after 3 months on nicardipine SR with no change in heart rate. Blood lipids did not change significantly. The disappearance rate of the lipid emulsion in the ivFTT showed no significant change (K2 was 1.93% /min after placebo, 1.84 after nicardipine 20 mg and 1.71 after chronic treatment). The results suggest that nicardipine is an effective antihypertensive drug and that it is devoid of untoward effects on lipid metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02333014
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular cloning of the o2-m5 allele of Zea mays using transposon marking (1988)
    Springer
    Molecular genetics and genomics 212 (1988), S. 488-494 
    Details
    ISSN: 1617-4623
    Keywords: Transposon tagging ; O2 gene ; Ac element
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The deposition of zein protein in maize endosperm is under the control of several regulatory loci. The isolation of DNA sequences corresponding to Opaque-2 (O2), one of such loci, is described in this paper. The mutable allele, o2-m5 was first induced moving the Ac transposable element present at the wx-m7 allele to the O2 locus. Genetic data suggest that a functional Ac element is responsible for the observed somatic mutability of o2-m5. The isolation of genomic clones containing flanking sequences corresponding to the O2 gene was possible by screening an o2-m5 genomic libary with a probe corresponding to internal Ac sequences usually absent in the defective element Ds. Out of 27 clones isolated with homology to the central part of Ac element, only clones 6IP and 21IP generated a 2.5 kb internal fragment size of an active Ac element when digested with PvuII restriction enzyme. A sequence representing a XhoI fragment of 0.9 kb lying, in the 6IP clone, adjacent to the Ac elements, was subcloned and utilized to prove that it corresponded to a part of the O2 gene. To obtain this information we made use of: (1) DNAs from several reversions originating from the unstable (o2mk-(r) allele, which, when digested with SstI, showed a correct 3.4 kb fragment typical of non-inserted alleles of the O2 locus; and (2) recessive alleles of the O2 locus which were devoid of a 2.0 kb mRNA, present on the contrary in the wild type and in other zein regulating mutants different from O2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00330854
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