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  • 5-azacytidine  (1)
  • Hypertension  (1)
  • Nicardipine  (1)
  • Springer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of lipid metabolism during antihypertensive treatment with nicardipine sr (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 225-227 
    Details
    ISSN: 1432-1041
    Keywords: Hypertension ; Hyperlipidaemia ; Nicardipine ; lipid metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The an tihypertensive and metabolic effects of oral nicardipine SR 40 mg b. i. d. have been studied in 18 (15 m, 3 f; age 52.7 y) hypertensives with mild hypercholesterolaemia, treated for 3 months after a 2 week period on placebo. An iv Fat Tolerance Test (FTT) was also performed in 8 patients following placebo, treatment with acute nicardipine 20 mg and chronic administration of nicardipine SR. There was a significant fall in BP from 160/97 on placebo to 147/87 after 3 months on nicardipine SR with no change in heart rate. Blood lipids did not change significantly. The disappearance rate of the lipid emulsion in the ivFTT showed no significant change (K2 was 1.93% /min after placebo, 1.84 after nicardipine 20 mg and 1.71 after chronic treatment). The results suggest that nicardipine is an effective antihypertensive drug and that it is devoid of untoward effects on lipid metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02333014
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  • 2
    Electronic Resource
    Electronic Resource
    Cytological evidence for 5-azacytidine-induced demethylation of the heterochromatic regions of human chromosomes (1996)
    Springer
    Chromosome research 4 (1996), S. 271-276 
    Details
    ISSN: 1573-6849
    Keywords: anti-5-methylcytosine antibody ; 5-azacytidine ; human chromosome ; methylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract This work was aimed at studying the effects of the demethylating agent 5-azacytidine (5-azaC) on the constitutive heterochromatin of human chromosomes at the cytological level. Metaphase preparations from peripheral blood lymphocyte and lymphoblastoid cultures obtained by standard methods were treated with the agent. Labelling of the heterochromatic regions was achieved by the indirect immunostaining method using anti-5-methylcytosine (5MeC) monoclonal antibodies and peroxidase-tagged second antibodies. 4-Chloro-1-naphthol (4C1N) was used as the substrate. The rate of methylation of individual chromosomes or chromosome groups was measured as the frequency of binding of anti-5MeC antibodies to specific chromosome regions. The following results were obtained: (i) in control cultures high intra- and interindividual variability in the binding frequencies of anti-5MeC antibodies to the short arm region of the acrocentrics was observed; (ii) 5-azaC consistently affects the methylation status of the constitutive heterochromatin; (iii) preferential demethylation occurs in the heterochromatic regions of specific chromosomes; (iv) under our experimental conditions the demethylating effect of 5-azaC appears not to be related to the well-known uncoiling effect of this drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02263676
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