ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Articles  (2)
  • 3H-palmitic acid  (1)
  • Brain
  • temperature adaptation
  • Springer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Transport von 3 H-Palmitinsäure im ZNS von Teleosteern (1970)
    Springer
    Cell & tissue research 110 (1970), S. 444-456 
    Details
    ISSN: 1432-0878
    Keywords: 3H-palmitic acid ; Optic tract ; Teleost brain ; Axonal flow ; Radio-autography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung An 23 Zebrafischen (Brachydanio rerio) und 9 Karauschen (Carassius carassius) wurde mit autoradiographischer Technik der Einbau von 3H-Palmitinsäure in die Lipoide des Tectum opticum und des Tractus opticus nach Inkorporationszeiten von 22 min bis zu 21 Tagen untersucht. 1. 3H-Palmitinsäure wird ohne Behinderung durch eine Bluthirnschranke in das ZNS aufgenommen und in Lipoidverbindungen eingebaut. 2. Die Lipoidsynthese erfolgt im Nervengewebe ubiquitär, verstärkt jedoch im membranreicheren Nervenfasermaterial. 3. Mit Hilfe einer Applikation von 3H-Palmitinsäure in den Glaskörper eines Auges ließ sich ein extra-axonaler Transport des Lipoidtracers im Tractus opticus nachweisen. 4. Den Nervenzellen des optischen Systems der Vertebraten kommt beim Stofftransport ein Selektionsvermögen zu für solche Stoffe a) die intra-axonal transportiert werden (Proteine, Serotonin, Chlorpromazin) b) die extra-axonal transportiert werden (Vorstufen von Polysacchariden und Lipoiden, Methamphetamin) und c) die nicht transloziert werden, sondern an ihrem Aufnahmeort festgehalten werden (Aminosäuren, Noradrenalin, Trypanblau, Diaminoacridin).
    Notes: Summary The incorporation of 3H-palmitic acid into the lipids of the optic tectum and the optic tract in 23 individuals of Brachydanio and 9 Carassius (teleosts) was investigated after incorporation periods ranging from 22 minutes to 51 days. 1. In the nervous system, there is no blood brain barrier for the incorporation of 3H-palmitic acid. 2. In the CNS, the synthesis of lipids is widely observed, but greater in nerve fibers. 3. Lipid precursors are conveyed in the optic tract extra-axonally, which has been shown by an intra-ocular application of 3H-palmitic acid. 4. Nerve cells of the optic system of vertebrates are capable of selecting those substances a) which are conveyed by intra-axonal flow (proteins, serotonin, chlorpromazine) b) which are conveyed extra-axonally (precursors of polysaccharides and lipids, methamphetamine), and c) which are not conveyed but held back at the site of entry into the cell (amino acids, norepinephrine, trypan blue, diaminoacridine).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00321151
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Gangliosides Affect Membrane-Channel Activities Dependent on Ambient Temperature (2000)
    Springer
    Cellular and molecular neurobiology 20 (2000), S. 579-590 
    Details
    ISSN: 1573-6830
    Keywords: bilayer ; alamethicin ; homoioviscosity ; gangliosides ; temperature adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 1. The functional properties of biological membranes depend on their molecular composition. In regard to this, charged glycosphingolipids play an outstanding role in the functional adaptation of membranes to different temperatures. 2. In order to shed some light on the respective functional properties of complex membraneous glycosphingolipids, the effects of altered temperatures (5–40°C) on planar lipid bilayers made from diphytanoylphosphatidylcholine (DPPC) and alamethicin as an ion channel was analyzed in the presence of either a sialoglycosphingolipid (less polar disialoganglioside GD1a or highly polar tetrasialoganglioside GQ1b) or phosphatidylserine (PS; as control). 3. Different to the control bilayers made from DPPC or DPPC + PS, the bilayers containing gangliosides had specific maxima in alamethicin conductance and stabile life times. Changes in pore-state conductances indicate structural effects based on an interaction of the large (negatively charged) ganglioside headgroups with the alamethicin pores. 4. The results concerning open time and closed time of channels seem to be based on the gangliosides changing the viscosity of the bilayer and possibly introducing phase transitions. 5. Thus, the findings suggest that gangliosides (1) directly affect channel molecules via their headgroups and (2) may additionally affect the fluidity of membranes in order to maintain membrane homeoviscosity in areas surrounding ion channels independent from the environmental temperature. 6. The effects of gangliosides may be of special interest in describing the ability of neuronal adaptation of vertebrates to temperature and more general regarding the functional adaptation of neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007063928449
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...