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  • 14CO2 breath test  (1)
  • Best. von Blei  (1)
  • Springer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Assessment of drug metabolism in hepatic disease: Comparison of plasma kinetics of oral cyclobarbital and the intravenous aminopyrine breath test (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 95-101 
    Details
    ISSN: 1432-1041
    Keywords: cyclobarbital ; aminopyrine ; liver disease ; 14CO2 breath test ; barbiturate ; pharmacokinetics ; hepatic drug metabolism ; cirrhosis ; alcoholic liver disease ; viral hepatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The exhalation of 14CO2 derived from an i.v. tracer dose of [dimethylamine-14C]aminopyrine has been investigated in normal controls and patients. They subsequently ingested 200 mg cyclobarbital calcium in the evening and the decline in the plasma drug level over the following 2 days was measured by thin-layer chromatography. The peak specific activity of exhaled 14CO2 occurred 0.5–2 h after 14C-aminopyrine injection in the absence of liver disease and in non-cirrhotic liver disorders. It was delayed in certain patients with cirrhosis. Compared to 8 medically healthy subjects, 10 patients with acute viral hepatitis, 8 with cirrhosis and 10 with fatty liver exhibited a significantly increased half-life of 14CO2 exhalation. Normal mean values were found in 12 patients with non-cirrhotic alcoholic liver disease and in 14 patients with non-hepatic diseases. The cyclobarbital (CB) half-life was prolonged and the clearance reduced in patients with viral hepatitis, cirrhosis, or alcoholic liver damage as compared to data from 17 control subjects. Due to a larger apparent volume of distribution, patients with fatty liver disease had an increased CB half-life, although its clearance was normal. A close negative correlation was detected between the clearance and the logarithm of the CB level measured 36 h after drug ingestion. The oral CB test evaluated from a single blood sample taken about 36 h after drug administration appears to be a useful indicator of human drug metabolising capacity. Discrimination between patients with and without disordered liver function was similar in the two drug elimination tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00546715
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  • 2
    Electronic Resource
    Electronic Resource
    Neutronenaktivierungsanalyse kurzlebiger Nuklide mit Impuls- und Dauerbestrahlung (1974)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 272 (1974), S. 337-340 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Blei ; Aktivierungsanalyse, Neutronen ; kurzlebiges Pb-207 m
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Für die neutronenaktivierungsanalytische Bestimmung von Blei bietet sich nur das 0,8 s 207mPb an. Unter Verwendung einer schnellen Rohrpostanlage wurde deshalb untersucht, welche Empfindlichkeiten bei Dauer- und Impulsbestrahlungen im Reaktor zu erzielen sind. Dabei zeigte sich, daß unter idealen Bedingungen mit Impulsbestrahlungen noch 1 μg Blei gut zu erfassen ist, während bei Dauerbestrahlung sich eine Nachweisgrenze von 50 μg Blei ergibt. Bei den zu untersuchenden Proben verschob sich durch die matrixbedingte Totzeit dieses Verhältnis jedoch so, daß die Empfindlichkeitsgrenze sowohl für Dauer- als auch Impulsbestrahlung bei etwa 100 μg Blei lag.
    Notes: Abstract The only useful nuclide for neutron activation of lead is the 0.8 s 207mPb. Therefore, using a fast pneumatic transfer system, the sensitivities obtainable in steady state and pulse irradiation in a nuclear reactor were investigated. It turned out that under ideal conditions 1 μg lead is still easily measurable, whereas for steady state irradiation a sensitivity of 50 μg lead was found. However, for the samples to be investigated the dead-time caused by the matrix effected a shift of this relation in such a way that the sensitivity for steady state and pulse irradiation was about 100 μg lead.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00424018
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