ISSN:
1573-8221
Keywords:
ischemia
;
sarcoplasmic reticulum
;
peroxidation of lipids
;
muscle
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The development of ischemia was shown to be accompanied by inhibition of the Ca2+ enzyme transport system (ETS) (a decrease in the Ca2+/ATP ratio and in activity of Ca2+-dependent ATPase), which correlates with accumulation of the primary and secondary molecular lipid peroxidation products (POL) in vivo and in the membranes of the sarcoplasmic reticulum (SR) of the skeletal muscles. Administration of antioxidants (2,6-di-tert-butyl-4-methylphenol, α-tocopherol) prevents activation of POL in the ischemic muscle and partially protects the Ca2+ ETS against injury. Restoration of the blood flow after prolonged ischemia leads to further inhibition of the Ca2+ ETS while the concentration of POL products remains unchanged.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00798881
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