ISSN:
1573-8221
Keywords:
brain
;
memory
;
synapse
;
proteins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The intensity of metabolism of proteins with fast and slow turnover from cerebral cortical synaptosomes of rats trained in defensive movements, pseudotrained, and control animals was studied by determining their specific radioactivity 1 and 3 days, and 1, 3, 6, and 9 weeks after intraventricular injection of lysine-14C. Three fractions of synaptosomal proteins, differing in the overall values of their half-life (τ5 0) were found. An increase was found in the specific radioactivity of brain proteins of the trained animals compared with those of the pseudotrained and control rats. Values of τ5 0 were increased for the slowly metabolized fraction of synaptosomal protein fractions from the brain of the trained rats. The role of protein metabolism in brain synapses in the mechanisms of formation of long-term memory is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00834214
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