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  • Climate  (1)
  • Penicillium aurantiogriseum  (1)
  • Springer  (2)
  • Springer Nature
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  • Springer  (2)
  • Springer Nature
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  • 1
    Electronic Resource
    Electronic Resource
    Nephrotoxicity of Penicillium aurantiogriseum, a possible factor in the aetiology of Balkan Endemic Nephropathy (1988)
    Springer
    Mycopathologia 102 (1988), S. 21-30 
    Details
    ISSN: 1573-0832
    Keywords: nephrotoxin ; Penicillium aurantiogriseum ; Balkan Nephropathy ; mycotoxin ; glycopeptide ; cytotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Water-soluble components of a nephrotoxic isolate of Penicillium aurantiogriseum have been fractionated by sequential ion-exchange, size-exclusion gel filtration, reverse-phase silica chromatography and HPLC. Nephrotoxicity in the rat was confined to a size-exclusion fraction approximating to 1500 daltons, which also inhibited DNA synthesis in cultured kidney cells. The more sensitive in vitro assay allowed toxicity to be followed to a sub-fraction from gradient-elution HPLC which in further HPLC resolved into a small group of glycopeptides. Recent Yugoslavian P. aurantiogriseum isolates, from a village in which the idiopathic human disease Balkan Nephropathy is hyperendemic, elicited a similar nephropathology and were acutely cytotoxic, reinforcing a need to regard this novel Penicillium nephrotoxin as a potential factor in human nephropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00436248
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  • 2
    Electronic Resource
    Electronic Resource
    British weather: Conversation topic or serious health risk? (1996)
    Springer
    International journal of biometeorology 39 (1996), S. 151-155 
    Details
    ISSN: 1432-1254
    Keywords: Housing ; Climate ; Seasonal mortality ; Building ; Energy efficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract Britain is renowned for low indoor winter temperatures and a high rate of excess winter deaths and a causal association has been drawn between the two. A lack of priority given to energy efficiency here is often justified in terms of the mild climate. However, it can be shown that British climatic features may be related to poor health as long as poor standards of construction and insulation prevail. Legislation should therefore be implemented to improve standards both for new housing and refurbishment of much existing housing stock, not only for reasons of energy conservation but also for community health.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01211229
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    Paper (German National Licenses)
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