Publication Date:
2013-07-11
Description:
Deleted in breast cancer-1 (DBC1) is a nuclear protein that was originally proposed to be deleted in some breast cancers (1). However, to date, no direct experimental evidence exists that implicates DBC1 on tumorigenesis (2-3). The best characterized physiological roles of DBC1 are in the regulation of liver, fat metabolism, and apoptosis (4-9). Since alteration in cellular metabolism has been identified as an emerging “hallmark” of cancer, it is possible that DBC1 may be implicated in the regulation of cancer cell energy metabolism. However, at this point any role of DBC1 in cancer metabolism is only speculative. Furthermore, DBC1 has clearly emerged as a nuclear receptor binding protein, as it interacts with the estrogen and androgen receptors and the heme receptor Rev erb (10-15), as a regulator of epigenetic modifiers such as SIRT1, HDAC3, and SUV39H1 (4-7, 16-17) (Figure 1), and as a key component of the human spliceosome (28). In this review we will discuss the new developments in DBC1 research, its molecular structure, regulatory roles and implication in metabolism, ageing and cancer.
Print ISSN:
0144-8463
Electronic ISSN:
1573-4935
Topics:
Biology
,
Chemistry and Pharmacology
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