ISSN:
1573-8744
Keywords:
Acetaminophen kinetics
;
temporal variations
;
diurnal variations
;
extrahepatic metabolism
;
extraction ratio
;
chronopharmacokinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The pharmacokinetics of a single 40mg/kg dose of acetaminophen was investigated at 09h00 and 21h00 in Sprague-Dawley rats synchronized to a 12-h light-dark cycle. Acetaminophen was administered by the intraarterial, intravenous, intraperitoneal, and oral routes in order to determine the contribution of the gastrointestinal tract, liver, and lung to the oral extraction ratio of the drug. A mean oral extraction ratio of 0.46 was obtained at 21h00 as compared to 0.39 at 09h00. The mean extraction ratios of the gastrointestine, liver, and lung were 0.05, 0.41, and 0 at 09h00 and 0.18, 0.24, and 0.13 at 21h00, respectively. These results indicate that the extrahepatic metabolism of acetaminophen is important at 21h00, but is barely detectable at 09h00, whereas the hepatic extraction ratio is higher at 09h00 than at 21h00. Thus, there are temporal variations in the disposition of acetaminophen in the rat.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01062340
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