Publication Date:
2016-02-11
Description:
Article ER + breast cancer patients treated with endocrine therapies often acquire resistance and develop metastasis. In this study, the authors demonstrate that endocrine therapies can promote the self-renewal of CD133 hi /ER lo drug resistant cells with metastatic potential driven through the IL6-Notch3 axis activation. Nature Communications doi: 10.1038/ncomms10442 Authors: Pasquale Sansone, Claudio Ceccarelli, Marjan Berishaj, Qing Chang, Vinagolu K. Rajasekhar, Fabiana Perna, Robert L. Bowman, Michele Vidone, Laura Daly, Jennifer Nnoli, Donatella Santini, Mario Taffurelli, Natalie N. C. Shih, Michael Feldman, Jun J. Mao, Christopher Colameco , Jinbo Chen, Angela DeMichele, Nicola Fabbri, John H. Healey, Monica Cricca, Giuseppe Gasparre, David Lyden, Massimiliano Bonafé, Jacqueline Bromberg
Electronic ISSN:
2041-1723
Topics:
Biology
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Chemistry and Pharmacology
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Natural Sciences in General
,
Physics
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