Publication Date:
2016-04-07
Description:
Candidalysin is a fungal peptide toxin critical for mucosal infection Nature 532, 7597 (2016). doi:10.1038/nature17625 Authors: David L. Moyes, Duncan Wilson, Jonathan P. Richardson, Selene Mogavero, Shirley X. Tang, Julia Wernecke, Sarah Höfs, Remi L. Gratacap, Jon Robbins, Manohursingh Runglall, Celia Murciano, Mariana Blagojevic, Selvam Thavaraj, Toni M. Förster, Betty Hebecker, Lydia Kasper, Gema Vizcay, Simona I. Iancu, Nessim Kichik, Antje Häder, Oliver Kurzai, Ting Luo, Thomas Krüger, Olaf Kniemeyer, Ernesto Cota, Oliver Bader, Robert T. Wheeler, Thomas Gutsmann, Bernhard Hube & Julian R. Naglik Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate host immune responses. Such toxins have not been identified previously in human pathogenic fungi. Here we identify the first, to our
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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