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  • Articles  (32)
  • Springer  (24)
  • Oxford University Press  (8)
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  • Articles  (32)
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  • 1
    Electronic Resource
    Electronic Resource
    The roles of collagen genes in skeletal development and morphogenesis (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 194-195 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Molecular genetic analyses of osteochondrodysplasias in mice and humans have recently led to the identification of mutations in genes encoding structural proteins growth factor receptors and sulphate transporters. Further analyses of such inherited disorders, using rapid techniques for gene mapping, positional cloning and mutation detection, will undoubtedly uncover other genes that are important for skeletal development. Together with studies of transgenic mice, in which specific genes that are expressed in the skeleton are mutated, these analyses will provide insight into genes that are essential for skeletal morphogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01931087
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chromosome variants in children referred for cytogenetic examination from two paediatric departments during a 12-year-period (1980)
    Springer
    Human genetics 〈Berlin〉 56 (1980), S. 67-69 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The present study deals with frequency and clinical signs of children with chromosome variants. Previous studies of the possible effect of different chromosome variants on phenotype and risk of congenital abnormalities are controversial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00281571
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  • 3
    Electronic Resource
    Electronic Resource
    Cell selection in vivo (1980)
    Springer
    Human genetics 〈Berlin〉 55 (1980), S. 357-361 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A cytogenetic follow-up has been made of nine mixoploid children found among 11 148 consecutive newborn children. The frequency of the cell line with normal chromosomes increased in all but two, and the increase was statistically significant, being from 20% to 39% in four cases, and from 1% to 17% in three, while in one case there was no difference from the first to the last examination. The possibility that children with mixoploid chromosome abnormalities at birth will reveal no cell line with a chromosome abnormality in lymphocyte cultures as adults, despite having clinical signs of the chromosome aberration found in one cell line at birth is discussed, as is the question of cell selection in vivo. The mixoploid children had fewer clinical symptoms and fewer signs of the chromosome abnormalities found in some of their cells than children with the same chromosome abnormalities in all cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290218
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  • 4
    Electronic Resource
    Electronic Resource
    Incidence of chromosome abnormalities in newborn children. Comparison between incidences in 1969–1974 and 1980–1982 in the same area (1982)
    Springer
    Human genetics 〈Berlin〉 61 (1982), S. 98-101 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary As part of an ongoing study of the influence of environmental factors on pregnancy, childbirth, and fetuses, comparisons have been made between incidences in 1969–1974 and in 1980–1982 of chromosome aberrations in liverborn children in the same area of Denmark. The incidence of chromosome aberrations in the first period was 2.6 per 1000, compared with 4.1 per 1000 during the latter period. However, the difference was mainly due to an increase in inversions, and this in turn was due to a difference in chromosome staining methods between the two periods. It is concluded that the Danish study and similar studies in the United States, Canada, and Scotland indicate that early detection of chromosome aberrations by chromosome examination at birth is indicated in order to be able to inform and counsel parents of children with chromosome aberrations. Chromosome examination at birth is also of importance in the diagnosis of structural inheritable chromosome aberrations and consequent family investigation and genetic counseling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274195
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistochemistry of the intercellular matrix components and the epithelio-mesenchymal junction of the human tooth germ (1994)
    Springer
    Journal of molecular histology 26 (1994), S. 110-118 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The immunohistochemical localization of heparan sulphate, collagen type I, III and IV, laminin, tenascin, plasma- and cellular fibronectin was studied in tooth germs from human fetuses. The lamina basalis ameloblastica or membrana preformativa, which separates the pre-ameloblasts from the pre-dentin and dentin, contained heparan sulphate, collagen type IV, laminin and fibronectin. Enamel reacted with antifibronectin, but the reaction varied depending on the type of fibronectin and the source of antibody. In early pre-dentin, collagen type I, laminin, tenascin and fibronectin were present. In late pre-dentin and dentin collagen type I was found in intertubular dentin and in the zone between enamel and dentin. The close relationship between collagen type I in dentin and fibronectin in immature enamel is interesting, as it may contribute to the stabilization of the amelodentinal interface. In dental pulp, collagen type IV and laminin were found in the endothelial basement membranes. Collagen type I and III, tenascin and fibronectin were localized to the mesenchymal intercellular matrix. The results of this study have supported the assumption that the lamina basalis ameloblastica is a basement membrane, and have lead to the suggestion that ameloblasts are producers of fibronectin or a fibronectin-like substance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00157959
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  • 6
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    Seasonal variation in wax ester concentration and gut content in a Baltic Sea copepod [Limnocalanus macrurus (Sars 1863)] (2012)
    Oxford University Press
    Details
    Publication Date: 2012-03-08
    Description: Limnocalanus macrurus from Bothnian Bay in the northern part of the Baltic Sea was studied during the ice-free period (April–December) in order to understand its life history and feeding biology. Our data on the population dynamics indicated that reproduction occurred during the ice-covered period, during which lipid storage was reduced to a minimum. From spring to late summer, the lipid reserve increased by a factor of 3, while the gonads of adult females were immature during this period, continuing to December as indicated by the small size of the eggs. Average stomach fullness was always ca. 50% indicating continuous feeding activity. A newly developed denaturing high-performance liquid chromatography method was used to analyse the gut contents over the study period. More than 30 taxa (at different taxonomic levels) could be identified. However, phytoplankton was only represented by one taxon (Diatomophycea), and was restricted to July. Thus, adult L. macrurus seems to have a strongly carnivorous feeding preference in the northern Baltic Sea.
    Print ISSN: 0142-7873
    Electronic ISSN: 1464-3774
    Topics: Biology
    Published by Oxford University Press
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  • 7
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    PCR-DHPLC assay for the identification of predator-prey interactions (2012)
    Oxford University Press
    Details
    Publication Date: 2012-03-08
    Description: Denaturing high-performance liquid chromatography (DHPLC) is a relatively new method for separating amplicons in a mixture, and was recently developed for parasite detection in the blue crab Callinectes sapidus . That assay used a peptide nucleic acid (PNA) PCR hybridization blocking probe (PNA–PCR–DHPLC) to decrease the generic PCR bias of dominant templates (the host) in the mixture prior to separation on the DHPLC column, thus enhancing the less abundant parasite DNA. The same assay and rational can be used to investigate predator–prey interactions. However, in ecosystem studies with many predator–prey relationships, development of specific PNA-blocking probes for each predator would be too laborious. Here, we have developed a PCR–DHPLC assay excluding the dominant predator amplicons in a first DHPLC run, followed by re-amplification of the non-predator retention volumes and further separation and characterization in a second DHPLC run. This assay generated data on the specific trophic interactions between the calanoid copepod Limnocalanus macrurus and its prey from a seasonal sampling programme. The assay provides an efficient way for an unbiased screening of predator–prey relationships, and although developed for L. macrurus in this study, the approach has wide applicability for any predator–prey interaction.
    Print ISSN: 0142-7873
    Electronic ISSN: 1464-3774
    Topics: Biology
    Published by Oxford University Press
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  • 8
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    The roles of collagen genes in skeletal development and morphogenesis (1995)
    Springer
    Details
    Publication Date: 1995-03-01
    Print ISSN: 0014-4754
    Topics: Biology , Medicine
    Published by Springer
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  • 9
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    Sexual dimorphism in a feeding apparatus is driven by mate choice and not niche partitioning (2013)
    Oxford University Press
    Details
    Publication Date: 2013-11-22
    Description: The evolutionary origins of sexual dimorphism are credited to both natural and sexual selection. Sexual dimorphism in feeding structures, however, provides some of the clearest examples of ecologically driven dimorphism. Studies of bird bills have significantly aided these claims, but bird bills are also commonly used in pair formation behaviors, and thus their morphology could be subject to sexual selection. We tested 4 hypotheses of the evolution of sexual dimorphism using the feeding structure of a sexually dimorphic and a nondimorphic subspecies of the swamp sparrow, Melospiza georgiana . The increased bill volume of males was not explained by simple allometric relationships, ecological niche divergence between the sexes, or correlations with territory defense. Male bill volume was positively selected by female mate choice, as relative male bill volume predicted both the presence of and degree of cuckoldry. Further, male bill volume increased with age, and females may thus receive benefits by choosing larger billed males for social (direct benefits) or extrapair (indirect benefits) mates. It is clear from this example that sexual selection can play a role in the evolution of sexually dimorphic feeding structures, even in bird bills, which are a classic system for ecologically driven sexual dimorphism.
    Print ISSN: 1045-2249
    Electronic ISSN: 1465-7279
    Topics: Biology
    Published by Oxford University Press
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  • 10
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    The influence of wind selectivity on migratory behavioral strategies (2018)
    Oxford University Press
    Details
    Publication Date: 2018-03-06
    Description: Air and water currents affect the timing and energy expenditure of many migratory animals, and therefore selection of favorable currents is important for optimal migratory performance. However, waiting for favorable currents also incurs costs. Here we conduct an optimality analysis to determine how wind selectivity affects 3 migratory currencies: time, energy, and risk. To describe variation in these metrics under varying degrees of selectivity, we constructed an individual-based model to simulate fall migration of passerines across eastern North America, allowing birds to use different thresholds of wind profit as the criterion for daily departure. A gradient of thresholds were tested across a range of realistic wind currents, from initiating flights only on nights when winds were directed in their preferred migratory direction (highly selective), to flying under most wind conditions (low selectivity). Our analysis indicated that relative mortality risk was lowest at intermediate selectivity; energy expended during flight was least for the most selective individuals; and of those that successfully completed migration, time spent on migration was lowest for the least selective birds. We solved for the optimal range of wind selectivity and show that this departure criterion alone can produce a tradeoff between time and energy that has been seen in many other behavioral contexts. While we solved for optima using some conditions specific to eastern North America, we show that variation in wind selectivity at departure can produce migratory behaviors that mimic the classic “time-minimizer” and “energy-minimizer” strategies developed from measurements of wild birds across multiple continents.
    Print ISSN: 1045-2249
    Electronic ISSN: 1465-7279
    Topics: Biology
    Published by Oxford University Press
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