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  • chloropromazine  (2)
  • Springer  (2)
  • Oxford University Press
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  • Springer  (2)
  • Oxford University Press
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  • 1
    Electronic Resource
    Electronic Resource
    In vitro andin vivo effect of chloropromazine, imipramine and lithium chloride on monoamine oxidase activity in rat brain mitochondria (1987)
    Springer
    Bioscience reports 7 (1987), S. 701-704 
    Details
    ISSN: 1573-4935
    Keywords: monoamine oxidase ; chloropromazine ; imipramine ; lithium chloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Chloropromazine (CPZ) and imipramine at a concentration of 1×10−3 M inhibit rat brain mitochondrial monoamine oxidase activity in vitro by 70 and 55% respectively, while lithium, even at a concentration of 0.05 M, inhibits the activity of this enzyme very negligibly (4%). In vivo, these drugs at a dose level of 56 mg CPZ, 76 mg Jimipramine and 76 mg lithium chloride/Kg body wt., did not cause any observable variation from normal in brain mitochondrial monoamine oxidase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01116862
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  • 2
    Electronic Resource
    Electronic Resource
    Antidepressants and brain respiration (1991)
    Springer
    Bioscience reports 11 (1991), S. 11-14 
    Details
    ISSN: 1573-4935
    Keywords: amphetamine ; chloropromazine ; clorgyline ; deprenyl ; lithium chloride ; tranylcypromine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Imipramine and clorgyline, at concentrations of 0.002 M, inhibit the respiration of brain tissue by 82 and 71 per cent respectively, while chloropromazine and tranylcypromine, at concentrations of 0.01 M, inhibit it about 25 per cent. Deprenyl and amphetamine at a concentration of 0.002 M inhibit brain tissue respiration by 12 and 18 per cent respectively. Respiration in brain is least affected by lithium chloride (only 5 per cent inhibition).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01118600
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    Paper (German National Licenses)
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