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    Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila (2013)
    Oxford University Press
    Details
    Publication Date: 2013-03-13
    Description: Chromatin insulators are functionally conserved DNA–protein complexes situated throughout the genome that organize independent transcriptional domains. Previous work implicated RNA as an important cofactor in chromatin insulator activity, although the precise mechanisms are not yet understood. Here we identify the exosome, the highly conserved major cellular 3' to 5' RNA degradation machinery, as a physical interactor of CP190-dependent chromatin insulator complexes in Drosophila. Genome-wide profiling of exosome by ChIP-seq in two different embryonic cell lines reveals extensive and specific overlap with the CP190, BEAF-32 and CTCF insulator proteins. Colocalization occurs mainly at promoters but also boundary elements such as Mcp , Fab-8 , scs and scs' , which overlaps with a promoter. Surprisingly, exosome associates primarily with promoters but not gene bodies of active genes, arguing against simple cotranscriptional recruitment to RNA substrates. Similar to insulator proteins, exosome is also significantly enriched at divergently transcribed promoters. Directed ChIP of exosome in cell lines depleted of insulator proteins shows that CTCF is required specifically for exosome association at Mcp and Fab-8 but not other sites, suggesting that alternate mechanisms must also contribute to exosome chromatin recruitment. Taken together, our results reveal a novel positive relationship between exosome and chromatin insulators throughout the genome.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 2
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    Gender balance: Women are funded more fairly in social science (2015)
    Nature Publishing Group (NPG)
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    Publication Date: 2015-09-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boyle, Paul J -- Smith, Lucy K -- Cooper, Nicola J -- Williams, Kate S -- O'Connor, Henrietta -- England -- Nature. 2015 Sep 10;525(7568):181-3. doi: 10.1038/525181a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Leicester, UK. From 2010 to 2014, he was chief executive of the United Kingdom's Economic and Social Research Council. ; Department of Health Sciences, University of Leicester, UK. ; Department of Sociology, University of Leicester, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26354468" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Organized/economics/*statistics & numerical data ; Great Britain ; Sex Factors ; Sexism/*statistics & numerical data ; Social Sciences/*economics/*manpower ; Women's Rights/*statistics & numerical data
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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