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  • 1
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    Reading of concentration gradients by axonal growth cones (2000)
    The Royal Society
    Details
    Publication Date: 2000-07-29
    Description: Wiring up the nervous system occurs as a self–organizing process during animal development. It has long been proposed that directional growth of axons towards their targets is achieved by gradients of guiding molecules and the conceptual framework of gradient guidance was introduced more than a decade ago. Novel experimental results now allow the formulation of models incorporating more mechanistic detail. We first summarize some crucial in vitro and in vivo results concerning the development of the chick retinotectal projection. We then review two recent theoretical models based on these findings (the models of Nakamoto and colleagues, and of Honda). Neither model considers the latest observation that putative guidance ligands, in addition to their tectal expression, are expressed in a similar pattern on the retina and that a disturbance of this expression affects topography. These findings suggest that retinal axons might grow into the tectum until they have reached a ligand concentration matching that of their site of origin. We call this the imprint–matching concept of retinotectal guidance. As a framework for pinpointing logical difficulties of the mechanistic description of the guidance process and to stimulate further experiments we finally suggest two extended versions of Honda's model implementing imprint matching, which we call ‘the variable set–point’ and ‘the gradient–sensitive adaptation’ model. Strengths and weaknesses of both mechanisms are discussed.
    Print ISSN: 0962-8436
    Electronic ISSN: 1471-2970
    Topics: Biology
    Published by The Royal Society
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  • 2
    Electronic Resource
    Electronic Resource
    Recognition of cell types by axonal growth cones in vitro (1980)
    [s.l.] : Nature Publishing Group
    Nature 288 (1980), S. 162-164 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The experimental design is shown in Fig. 1. Axons originating from expiants of chick retina grow through a zone where they are simultaneously exposed to two different cell types (retinal and tectal cells) and where they may 'choose' the more attractive one. A retinal expiant is spread on a black ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/288162a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Position-dependent properties of retinal axons and their growth cones (1985)
    [s.l.] : Nature Publishing Group
    Nature 315 (1985), S. 409-410 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. l Schematic description of the experiment, a, Phase-contrast diagram of axon growth, with first explantations at O h; ò, explantation of fluorescent explants at 24 h; c, addition of a-laminin at 40h. Axons visualized at 16, 40 and 70h. T, temporal; N, nasal. Methods. Nasal and temporal ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/315409a0
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  • 4
    Electronic Resource
    Electronic Resource
    Inhibition of axonal growth by a monoclonal antibody (1983)
    [s.l.] : Nature Publishing Group
    Nature 303 (1983), S. 65-67 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Membranes were prepared from retinae of 9-day-old chick embryos as described by Halfter et a/.4. 100 jjig of membrane protein were injected 20 times at weekly intervals intra-peritoneally and intravenously into female BALB/c mice; 3| days after the last boost, spleen cells from one mouse were fused ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/303065a0
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  • 5
    Electronic Resource
    Electronic Resource
    Replication of Escherichia coli requires DNA polymerase I (1974)
    [s.l.] : Nature Publishing Group
    Nature 250 (1974), S. 513-514 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Among many DNA polymerase I mutants of E. coli we have isolated one (BT 4113) which is conditional lethal at elevated temperature because of a temperature-sensitive DNA polymerase I. A bacterial culture was mutagenised by N-methyl-nitrosoguanidine and screened for pol A mutants using a new replica ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/250513a0
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  • 6
    Electronic Resource
    Electronic Resource
    DNA Synthesis in vitro (1970)
    [s.l.] : Nature Publishing Group
    Nature 226 (1970), S. 711-713 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In a new in vitro system, DNA is synthesized semiconservatively at rates of chain growth comparable with replication in vivo. This DNA synthesis is also observed with a strain of E. coli, which lacks DNA polymerase activity in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/226711a0
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