ISSN:
1573-3297
Keywords:
morbidity risks
;
reduced fertility
;
genetic modeling
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Psychology
Notes:
Abstract Reduced fertility for a disease can greatly influence the estimation of morbid risk in various classes of relatives. The strongest effect is on parents of probands. Essen-Möller [(1955).Acta Genet. 5:334–342] derived an approximate correction for the morbid risk to parents and applied it to a sample of schizophrenics. That reduced fertility can also diminish the observed morbid risk to other classes of relative, such as siblings, grandchildren, niece/nephew, etc., seems to have been unappreciated in the literature. This report gives a simple method for correcting the morbid risk estimate to parents under reduced fertility which requires fewer assumptions than the method of Essen-Möller (1955). In addition, a method is derived for determining the potential effect of reduced fertility on morbidity risk estimates for other classes of relatives.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01065920
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