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Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network [Colloquium Paper] (2017)

William J. R. Longabaugh, Weihua Zeng, Jingli A. Zhang, Hiroyuki Hosokawa, Camden S. Jansen, Long Li, Maile Romero-Wolf, Pentao Liu, Hao Yuan Kueh, Ali Mortazavi, Ellen V. Rothenberg

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2017-06-07

Description: T-cell development from hematopoietic progenitors depends on multiple transcription factors, mobilized and modulated by intrathymic Notch signaling. Key aspects of T-cell specification network architecture have been illuminated through recent reports defining roles of transcription factors PU.1, GATA-3, and E2A, their interactions with Notch signaling, and roles of Runx1, TCF-1, and...

Keywords: Sackler Colloquium on Gene Regulatory Networks and Network Models in Development and Evolution

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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