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  • Oxford University Press  (55)
  • National Academy of Sciences  (49)
  • Wiley-Blackwell  (5)
  • 1
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    Recent advances in molecular phylogeny, systematics and evolution of patellogastropod limpets (2011)
    Oxford University Press
    Details
    Publication Date: 2011-11-24
    Description: With the advent of molecular phylogenetics, the systematics and taxonomy of Patellogastropoda have been greatly improved. Eight families and 36 genera are currently recognized in the order. We review recent published papers that have used molecular data, discuss the resulting advances in systematics and evolution of Patellogastropoda and suggest directions of future research.
    Print ISSN: 0260-1230
    Electronic ISSN: 1464-3766
    Topics: Biology
    Published by Oxford University Press
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  • 2
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    Structure and formation of the twisted plywood pattern of collagen fibrils in rat lamellar bone (2012)
    Oxford University Press
    Details
    Publication Date: 2012-04-16
    Description: This study was designed to elucidate details of the structure and formation process of the alternate lamellar pattern known to exist in lamellar bone. For this purpose, we examined basic internal lamellae in femurs of young rats by transmission and scanning electron microscopy, the latter employing two different macerations with NaOH at concentrations of 10 and 24%. Observations after the maceration with 10% NaOH showed that the regular and periodic rotation of collagen fibrils caused an alternation between two types of lamellae: one consisting of transversely and nearly transversely cut fibrils, and the other consisting of longitudinally and nearly longitudinally cut fibrils. This finding confirms the consistency of the twisted plywood model. The maceration method with 24% NaOH removed bone components other than cells, thus allowing for three-dimensional observations of osteoblast morphology. Osteoblasts extended finger-like processes paralleling the inner bone surface, and grouped in such a way that, within a group, the processes arranged in a similar direction. Transmission electron microscopy showed that newly deposited fibrils were arranged alongside these processes. For the formation of the alternating pattern, our findings suggest that: (1) osteoblasts control the collagen fibril arrangement through their finger-like process position; (2) osteoblasts behave similarly within a group; (3) osteoblasts move their processes synchronously and periodically to promote alternating different fibril orientation; and (4) this dynamic sequential deposition of fibrils results in the alternate lamellar (or twisted plywood) pattern.
    Print ISSN: 0022-0744
    Electronic ISSN: 1477-9986
    Topics: Electrical Engineering, Measurement and Control Technology , Natural Sciences in General , Physics
    Published by Oxford University Press on behalf of The Japanese Electron Microscopy Society.
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  • 3
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    Mitochondrial fission controls mtDNA and apoptosis [Cell Biology] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-07-17
    Description: Mammalian cells typically contain thousands of copies of mitochondrial DNA assembled into hundreds of nucleoids. Here we analyzed the dynamic features of nucleoids in terms of mitochondrial membrane dynamics involving balanced fusion and fission. In mitochondrial fission GTPase dynamin-related protein (Drp1)-deficient cells, nucleoids were enlarged by their clustering within hyperfused...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    Identification and analysis of large intergenic non-coding RNAs regulated by p53 family members through a genome-wide analysis of p53-binding sites (2014)
    Oxford University Press
    Details
    Publication Date: 2014-05-09
    Description: p53 is one of the most important known tumor suppressor genes, and it is inactivated in approximately half of human cancers. p53 family members execute various functions, such as apoptosis induction and cell cycle arrest, by modulating transcriptional regulation. Therefore, the direct transcriptional targets of the p53 family must be explored to elucidate the functional mechanisms of family members. To identify the direct transcriptional targets of p53 family members, we performed chromatin immunoprecipitation together with next-generation sequencing (ChIP-seq) and searched for p53-binding motifs across the entire human genome. Among the identified ChIP-seq peaks, approximately half were located in an intergenic region. Therefore, we assumed large intergenic non-coding RNAs (lincRNAs) to be major targets of the p53 family. Recent reports have revealed that lincRNAs play an important role in various biological and pathological processes, such as development, differentiation, stemness and carcinogenesis. Through a combination of ChIP-seq and in silico analyses, we found 23 lincRNAs that are upregulated by the p53 family. Additionally, knockdown of specific lincRNAs modulated p53-induced apoptosis and promoted the transcription of a gene cluster. Our results suggest that p53 family members, and lincRNAs constitute a complex transcriptional network involved in various biological functions and tumor suppression.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 5
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    Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats (2012)
    Oxford University Press
    Details
    Publication Date: 2012-10-12
    Description: This study aimed at elucidating whether estrogen deficiency would affect the synthesis of an osteocyte-derived factor, sclerostin, in the mesial region of alveolar bone. Eight 9-week-old Wistar female rats were ovariectomized (OVX) and eight other rats were Sham-operated (Sham). After 4 weeks, the interradicular septa of mandibular first molar were embedded in paraffin and then histochemically examined. Sclerostin-positive osteocytes were located in the superficial layer of the mesial region of Sham bones, whereas the OVX mesial region showed less sclerostin-reactive osteocytes. There was no significant difference in the distribution of estrogen receptor α and terminal deoxynucleotidyl transferase-mediated deoxyuridinetriphosphate nick end-labeling -positive cells in the groups studied. The Sham mesial region featured many osteoclasts, and OVX specimens showed numerous osteoclasts in association with intense immunolabeling of the receptor activator of the nuclear factor kB ligand. Contrary to the observations in Sham specimens, a complex meshwork of cement lines was seen in the OVX mesial region, accompanied by an irregularly distributed osteocytic lacunar–canalicular system. In conclusion, estrogen deficiency appears to inhibit osteocyte-derived sclerostin synthesis in the mesial region of the interradicular septum, in a process that seems to be mediated by accelerated bone remodeling rather than by direct effects on osteocytes.
    Print ISSN: 0022-0744
    Electronic ISSN: 1477-9986
    Topics: Electrical Engineering, Measurement and Control Technology , Natural Sciences in General , Physics
    Published by Oxford University Press on behalf of The Japanese Electron Microscopy Society.
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of bending and stretching of polyethylene strips on the adsorption of surface-active substances (1970)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-2: Polymer Physics 8 (1970), S. 595-603 
    Details
    ISSN: 0449-2978
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The adsorption of tritium-labeled sodium stearate and 35S-labeled sodium dodecylsulfate from aqueous solution on bent and on stretched polyethylene strips was directly measured. The amount of adsorption increased from 2.5 to 4.5 times on surfaces of various polyethylene samples stretched from 5.2 to 5.3 times the original length. For one sample, adsorption increased 8 and 2.5 times, respectively, on the convex and concave surfaces of a bent strip. Autoradiographs of the strips taken after adsorption revealed the appearance of both homogeneous and heterogeneous adsorption on the stretched surface of the polyethylene. The electron micrographs of the strips showed that many small fissures, about 1-5μ in length, formed on their surfaces after the strips were bent or stretched. Enhanced adsorption of the surface-active substance along these fissures was suggested. On the basis of these observations, it is proposed that in stretching or bending, fissures increase adsorption of the detergent, and the adsorption in turn promotes further development of fissures. Thus, bending and adsorption mutually promote the growth of fissures which finally result in failure of the polyethylene.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1970.160080410
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  • 7
    Electronic Resource
    Electronic Resource
    Template-assisted nano-patterning of solid surfaces (1998)
    New York : Wiley-Blackwell
    Biopolymers 47 (1998), S. 185-193 
    Details
    ISSN: 0006-3525
    Keywords: surface modification ; template approach ; self-assembly ; protein monolayer ; molecular imprinting ; implant material ; protein adsorption - X-ray photoelectron spectroscopy ; surface pattern - biocompatibility of, cyclic peptide for, porphyrin for ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Protein layers are deposited on the surface of implanted biomaterials. Better understanding of the interaction between the surface protein layers and the biological system would lead to the development of future biomaterials with superior biocompatibilities. Well-organized biorecognizable surfaces can be formed with various template molecules that provide an appropriate spacing for the attachment of recognition groups to the modified surface. Silane coupling reagents, porphyrin thiols, and cyclic peptides are being used as templates to introduce nano-scale patterns on solid surfaces. Synthesis of these templates and characterization of the modified surface are described. © 1998 John Wiley & Sons, Inc. Biopoly 47: 185-193, 1998
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Creep recovery of acrylate urethane oligomer/acrylate networks (1996)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 61 (1996), S. 1413-1421 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Creep recovery of acrylate urethane/acrylate networks was investigated as a function of time and temperature. An important outcome was the capacity for superimposition of experimental data obtained at various temperatures. Arrhenius type temperature dependence of the creep recovery was also observed. The master curve obtained did not significantly depend on the measuring mode of creep recovery or the crosslink density, and the response could be approximated by the Bueche theory. The dynamic mechanical properties of the systems were also investigated. Retardation spectrum L obtained from the dynamic mechanical data overlapped with that obtained from the creep recovery data. The activation energy obtained from the temperature dependence of the shift factor aT also agreed with that obtained from the temperature dependence of the creep recovery. © 1996 John Wiley & Sons, Inc.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    High-resolution scanning electron microscopy of the cells of mineralized tissues (1985)
    New York, NY : Wiley-Blackwell
    Journal of Electron Microscopy Technique 2 (1985), S. 271-272 
    Details
    ISSN: 0741-0581
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Natural Sciences in General
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jemt.1060020316
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  • 10
    Electronic Resource
    Electronic Resource
    Über farblose und farbige isomere Kohlenwasserstoffe der Diphensuccinden-Reihe. (12. Mitteilung über Verbindungen der Diphensuccinden-Reihe.) (1925)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 58 (1925), S. 2546-2550 
    Details
    ISSN: 0365-9631
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19250581112
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