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  • 1
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    Landslide Susceptibility Prediction Considering Regional Soil Erosion Based on Machine-Learning Models (2020)
    Molecular Diversity Preservation International
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    Publication Date: 2020-06-08
    Description: Soil erosion (SE) provides slide mass sources for landslide formation, and reflects long-term rainfall erosion destruction of landslides. Therefore, it is possible to obtain more reliable landslide susceptibility prediction results by introducing SE as a geology and hydrology-related predisposing factor. The Ningdu County of China is taken as a research area. Firstly, 446 landslides are obtained through government disaster survey reports. Secondly, the SE amount in Ningdu County is calculated and nine other conventional predisposing factors are obtained under both 30 m and 60 m grid resolutions to determine the effects of SE on landslide susceptibility prediction. Thirdly, four types of machine-learning predictors with 30 m and 60 m grid resolutions—C5.0 decision tree (C5.0 DT), logistic regression (LR), multilayer perceptron (MLP) and support vector machine (SVM)—are applied to construct the landslide susceptibility prediction models considering the SE factor as SE-C5.0 DT, SE-LR, SE-MLP and SE-SVM models; C5.0 DT, LR, MLP and SVM models with no SE are also used for comparisons. Finally, the area under receiver operating feature curve is used to verify the prediction accuracy of these models, and the relative importance of all the 10 predisposing factors is ranked. The results indicate that: (1) SE factor plays the most important role in landslide susceptibility prediction among all 10 predisposing factors under both 30 m and 60 m resolutions; (2) the SE-based models have more accurate landslide susceptibility prediction than the single models with no SE factor; (3) all the models with 30 m resolutions have higher landslide susceptibility prediction accuracy than those with 60 m resolutions; and (4) the C5.0 DT and SVM models show higher landslide susceptibility prediction performance than the MLP and LR models.
    Electronic ISSN: 2220-9964
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Published by Molecular Diversity Preservation International
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  • 2
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    Quinolone and Organophosphorus Insecticide Residues in Bivalves and Their Associated Risks in Taiwan (2020)
    Molecular Diversity Preservation International
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    Publication Date: 2020-08-10
    Description: Bivalves, such as freshwater clams (Corbicula fluminea) and hard clams (Meretrix lusoria), are the most extensive and widely grown shellfish in land-based ponds in Taiwan. However, few studies have examined the contamination of bivalves by quinolone and organophosphorus insecticides. Thus, we adapted an established procedure to analyze 8 quinolones and 12 organophosphorus insecticides using liquid and gas chromatography–tandem mass spectrometry. Surveys in Taiwan have not noted high residual levels of these chemicals in bivalve tissues. A total of 58 samples of freshwater or hard clams were obtained from Taiwanese aquafarms. We identified 0.03 mg/kg of enrofloxacin in one freshwater clam, 0.024 mg/kg of flumequine in one freshwater clam, 0.02 mg/kg of flumequine in one hard clam, 0.05 mg/kg of chlorpyrifos in one freshwater clam, 0.03 mg/kg of chlorpyrifos in one hard clam, and 0.02 mg/kg of trichlorfon in one hard clam. The results indicated that 5.17% of the samples had quinolone insecticide residues and 5.17% had organophosphorus residues. However, the estimated daily intake (EDI)/acceptable daily intake quotient (ADI) indicated no significant risk and no immediate health risk from the consumption of bivalves. These results provide a reference for the food-safety screening of veterinary drugs and pesticides in aquatic animals. Aquatic products should be frequently screened for residues of prohibited chemicals to safeguard human health.
    Electronic ISSN: 1420-3049
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 3
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    Intraprostatic Botulinum Neurotoxin Type A Injection for Benign Prostatic Hyperplasia—A Spotlight in Reality (2016)
    Molecular Diversity Preservation International
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    Publication Date: 2016-04-26
    Electronic ISSN: 2072-6651
    Topics: Chemistry and Pharmacology , Medicine
    Published by Molecular Diversity Preservation International
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  • 4
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    Therapeutic Efficacy of onabotulinumtoxinA Delivered Using Various Approaches in Sensory Bladder Disorder (2020)
    Molecular Diversity Preservation International
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    Publication Date: 2020-01-23
    Description: Cystoscopic onabotulinumtoxinA (onaBoNTA) intradetrusor injection is an efficient and durable modality for treating sensory bladder disorders. However, the inconvenience of using the cystoscopic technique and anesthesia, and the adverse effects of direct needle injection (e.g., haematuria, pain, and infections) have motivated researchers and clinicians to develop diverse injection-free procedures to improve accessibility and prevent adverse effects. However, determining suitable approaches to transfer onaBoNTA, a large molecular and hydrophilic protein, through the impermeable urothelium to reach therapeutic efficacy remains an unmet medical need. Researchers have provided potential solutions in three categories: To disrupt the barrier of the urothelium (e.g., protamine sulfate), to increase the permeability of the urothelium (e.g., electromotive drug delivery and low-energy shock wave), and to create a carrier for transportation (e.g., liposomes, thermosensitive hydrogel, and hyaluronan-phosphatidylethanolamine). Thus far, most of these novel administration techniques have not been well established in their long-term efficacy; therefore, additional clinical trials are warranted to validate the therapeutic efficacy and durability of these techniques. Finally, researchers may make progress with new combinations or biomaterials to change clinical practices in the future.
    Electronic ISSN: 2072-6651
    Topics: Chemistry and Pharmacology , Medicine
    Published by Molecular Diversity Preservation International
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  • 5
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    Promise and the Pharmacological Mechanism of Botulinum Toxin A in Chronic Prostatitis Syndrome (2019)
    Molecular Diversity Preservation International
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    Publication Date: 2019-10-11
    Description: Chronic prostatitis/chronic pelvic pain syndrome (CP/ CPPS) has a negative impact on the quality of life, and its etiology still remains unknown. Although many treatment protocols have been evaluated in CP/CPPS, the outcomes have usually been disappointing. Botulinum neurotoxin A (BoNT-A), produced from Clostridium botulinum, has been widely used to lower urinary tract dysfunctions such as detrusor sphincter dyssynergia, refractory overactive bladder, interstitial cystitis/bladder pain syndromes, benign prostatic hyperplasia, and CP/ CPPS in urology. Here, we review the published evidence from animal models to clinical studies for inferring the mechanism of action underlying the therapeutic efficacy of BoNT in CP/CPPS. Animal studies demonstrated that BoNT-A, a potent inhibitor of neuroexocytosis, impacts the release of sensory neurotransmitters and inflammatory mediators. This pharmacological action of BoNT-A showed promise of relieving the pain of CP/CPPS in placebo-controlled and open-label BoNT-A and has the potential to serve as an adjunct treatment for achieving better treatment outcomes in CP/CPPS patients.
    Electronic ISSN: 2072-6651
    Topics: Chemistry and Pharmacology , Medicine
    Published by Molecular Diversity Preservation International
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  • 6
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    Ultra-Stable UiO-66 Involved Molecularly Imprinted Polymers for Specific and Sensitive Determination of Tyramine Based on Quartz Crystal Microbalance Technology (2020)
    Molecular Diversity Preservation International
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    Publication Date: 2020-01-31
    Description: A rapid method was developed to determine the content of tyramine in food on the basis of the combination of molecular imprinting technique and the metal-organic frameworks. We developed the new molecular imprinted polymers based on metal-organic frameworks UiO-66 (named UiO-66@MIPs) as the sensing recognition element, the non-molecular imprinted polymers based on UiO-66 (named UiO-66@NIPs) was synthesized according the same steps without tyramine for comparison. The characterization of obtained UiO-66@MIPs was investigated through a series of characterization experiments. The results indicated that the octahedral shaped UiO-66 was encapsulated in the sol-gel polymer film, with a desirable thermal stability and possessed a specific surface area (SSA) of 994.3 m2·g−1. The imprinting factor of the UiO-66@MIPs for tyramine was 1.956 in static experiment. This indicates the synthesized UiO-66@MIPs have outstanding performance compered to UiO-66@NIPs on the static adsorption quantity and selective adsorption affinity. It’s to make use of advantages of the synthetic materials to develop a quartz crystal microbalance (QCM) sensor for the sensitive detection of tyramine. The detection limit of the system was 61.65 μg·L−1 within measurable concentration range from 80 to 500 μg·L−1. The prepared QCM sensor was verified in selectivity and application. The UiO-66@MIPs possess good behavior on selectivity, absorptivity, and chemical stability, so the UiO-66@MIPs achieve accurate and rapid trace detection of biogenic amines in food combining with the quartz crystal microbalance.
    Electronic ISSN: 2073-4360
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Published by Molecular Diversity Preservation International
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  • 7
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    Recent Progress on Luminescent Metal-Organic Framework-Involved Hybrid Materials for Rapid Determination of Contaminants in Environment and Food (2020)
    Molecular Diversity Preservation International
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    Publication Date: 2020-03-20
    Description: The high speed of contaminants growth needs the burgeoning of new analytical techniques to keep up with the continuous demand for monitoring and legislation on food safety and environmental pollution control. Metal-organic frameworks (MOFs) are a kind of advanced crystal porous materials with controllable apertures, which are self-assembled by organic ligands and inorganic metal nodes. They have the merits of large specific surface areas, high porosity and the diversity of structures and functions. Latterly, the utilization of metal-organic frameworks has attracted much attention in environmental protection and the food industry. MOFs have exhibited great value as sensing materials for many targets. Among many sensing methods, fluorometric sensing is one of the widely studied methods in the detection of harmful substances in food and environmental samples. Fluorometric detection based on MOFs and its functional materials is currently one of the most key research subjects in the food and environmental fields. It has gradually become a hot research direction to construct the highly sensitive rapid sensors to detect harmful substances in the food matrix based on metal-organic frameworks. In this paper, we introduced the synthesis and detection application characteristics (absorption, fluorescence, etc.) of metal-organic frameworks. We summarized their applications in the MOFs-based fluorometric detection of harmful substances in food and water over the past few years. The harmful substances mainly include heavy metals, organic pollutants and other small molecules, etc. On this basis, the future development and possible application of the MOFs have prospected in this review paper.
    Electronic ISSN: 2073-4360
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Published by Molecular Diversity Preservation International
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  • 8
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    Low Energy Shock Wave Therapy Inhibits Inflammatory Molecules and Suppresses Prostatic Pain and Hypersensitivity in a Capsaicin Induced Prostatitis Model in Rats (2019)
    Molecular Diversity Preservation International
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    Publication Date: 2019-09-26
    Description: The effect of low energy shock wave (LESW) therapy on the changes of inflammatory molecules and pain reaction was studied in a capsaicin (10 mM, 0.1 cc) induced prostatitis model in rats. Intraprostatic capsaicin injection induced a pain reaction, including closing of the eyes, hypolocomotion, and tactile allodynia, which effects were ameliorated by LESW treatment. LESW therapy (2Hz, energy flux density of 0.12 mJ/mm2) at 200 and 300 shocks significantly decreased capsaicin-induced inflammatory reactions, reflected by a reduction of tissue edema and inflammatory cells, COX-2 and TNF-α stained positive cells, however, the therapeutic effects were not observed at 100 shocks treated group. Capsaicin-induced IL-1β, COX-2, IL-6, caspase-1, and NGF upregulation on day 3 and 7, while NALP1 and TNF-α upregulation was observed on day 7. LESW significantly suppressed the expression of IL-1β, COX-2, caspase-1, NGF on day 3 and IL-1β, TNF-α, COX-2, NALP1, caspase-1, NGF expression on day 7 in a dose-dependent fashion. LESW has no significant effect on IL-6 expression. Intraprostatic capsaicin injection activates inflammatory molecules and induces prostatic pain and hypersensitivity, which effects were suppressed by LESW. These findings might be the potential mechanisms of LESW therapy for nonbacterial prostatitis in humans.
    Print ISSN: 1661-6596
    Electronic ISSN: 1422-0067
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 9
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    Mirtazapine Reduces Adipocyte Hypertrophy and Increases Glucose Transporter Expression in Obese Mice (2020)
    Molecular Diversity Preservation International
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    Publication Date: 2020-08-14
    Description: Metabolic syndrome is known to engender type 2 diabetes as well as some cardiac, cerebrovascular, and kidney diseases. Mirtazapine—an atypical second-generation antipsychotic drug with less severe side effects than atypical first-generation antipsychotics—may have positive effects on blood glucose levels and obesity. In our executed study, we treated male high-fat diet (HFD)-fed C57BL/6J mice with mirtazapine (10 mg/kg/day mirtazapine) for 4 weeks to understand its antiobesity effects. We noted these mice to exhibit lower insulin levels, daily food efficiency, body weight, serum triglyceride levels, aspartate aminotransferase levels, liver and epididymal fat pad weight, and fatty acid regulation marker expression when compared with their counterparts (i.e., HFD-fed control mice). Furthermore, we determined a considerable drop in fatty liver scores and mean fat cell size in the epididymal white adipose tissue in the treated mice, corresponding to AMP-activated protein kinase expression activation. Notably, the treated mice showed lower glucose tolerance and blood glucose levels, but higher glucose transporter 4 expression. Overall, the aforementioned findings signify that mirtazapine could reduce lipid accumulation and thus prevent HFD-induced increase in body weight. In conclusion, mirtazapine may be useful in body weight control and antihyperglycemia therapy.
    Electronic ISSN: 2076-2615
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Molecular Diversity Preservation International
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  • 10
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    Distribution, Removal, and Risk Assessment of Pharmaceuticals and Their Metabolites in Five Sewage Plants (2019)
    Molecular Diversity Preservation International
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    Publication Date: 2019-11-27
    Description: The extensive use of pharmaceuticals and personal care products (PPCPs) leads to a continuous increase of their presence in urban wastewater. These pollutants are discharged into natural waters and pose a threat to human health and the ecological environment. This study focused on five sewage treatment plants in three cities of China’s Yangtze River Delta as research sites to study the distribution and degradation of drugs and their conversion products in wastewater. The concentration of target compounds in the water ranged from 0 to 510.8 ng/L, and both positive and negative removal rates occurred during the treatment. Acetaminophen (ACE) and ibuprofen (IPF) can be completely removed in the biological treatment stage. The addition of flocculants and sand filtration has a positive effect on the removal of naproxen (NPX) and bezafibrate (BZB). Ultraviolet disinfection is beneficial for the removal of antipyrine (ATP) and diclofenac (DCF). A small amount of PPCPs were found in the sludge and particulate matter, which had little effect on removal. Finally, the risk quotients were used to evaluate the harmfulness of the PPCPs detected in the effluent to the ecological environment, and the results showed that there was little hazard.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by Molecular Diversity Preservation International
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