ALBERT

Description: The objective of this study is to follow the composite theory approach to analyze the effect of social capital on self-rated mental health in rural and urban China. Our nationally representative sample includes 10,968 respondents from 130 county-level communities. Two-level random-coefficient linear regressions, which model individual and community variations in subjective mental health, were estimated by taking the hierarchical structure of the dataset into account. We found that a significant proportion of the total variations in self-rated mental health were explained at the community level. We also found an association between low contextual civic trust and poor self-rated mental health after adjusting for individual social capital and individual socioeconomic-demographic variables. The study also revealed that: (1) in rural areas a positive relationship between civic and political trust and mental health existed both at the individual and the community level, respectively; and (2) in urban areas, only political trust at the individual level contributed to better mental health. In addition, the individual and community level political participation exhibited a positive impact on mental health measures in both rural and urban China. The individual level civic participation was positively associated to the outcome variable. However, the community-level civic participation seemed to negatively impact mental health in urban area. Our findings emphasize the importance of both individual and community-level healthcare interventions in China. Finally, this study also found that human capital covariates remained important predictors of self-rated mental health status even after controlling social capital both at individual and community levels. This study suggested that the composite thesis could provide a more convincing narrative than other theories in explaining the effects of both human and social capital on health.

Description: Sleep and work-family problems attract a great attention in the construction industry because construction professionals are usually prone to work-family conflicts and sleep problems. The objective of this study was to analyze the effect of Family-Role Overload (FRO) and Work Interference with Family (WIF) on sleep sufficiency. We also included life satisfaction as a mediator and family supportive supervision behaviors (FSSB) as a moderator. Using a sample of 193 Chinese construction professionals, we collected objectively-measured sleep sufficiency data with validated wrist actigraphies and self-reported sleep sufficiency data, FRO, WIF, life satisfaction and FSSB with questionnaires through multiple waves. Results demonstrated that FRO was negatively associated with both objectively-measured and self-reported sleep sufficiency and life satisfaction played an important mediating role in this relationship. The moderating effect of life satisfaction on the path between WIF and sleep sufficiency is trivial. In addition, no significant moderating effects of FSSB were found. More substantial policies should be taken to improve the life satisfaction and sleep sufficiency of construction professionals.

Description: The FDA (U.S. Food and Drug Administration) has approved only a negligible number of poly(lactide-co-glycolide) (PLGA)-based microsphere formulations, indicating the difficulty in developing a PLGA microsphere. A thorough understanding of microsphere formulations is essential to meet the challenge of developing innovative or generic microspheres. In this study, the key factors, especially the key process factors of the marketed PLGA microspheres, were revealed for the first time via a reverse engineering study on Vivitrol® and verified by the development of a generic naltrexone-loaded microsphere (GNM). Qualitative and quantitative similarity with Vivitrol®, in terms of inactive ingredients, was accomplished by the determination of PLGA. Physicochemical characterization of Vivitrol® helped to identify the critical process parameters in each manufacturing step. After being prepared according to the process parameters revealed by reverse engineering, the GNM demonstrated similarity to Vivitrol® in terms of quality attributes and in vitro release (f2 = 65.3). The research on the development of bioequivalent microspheres based on the similar technology of Vivitrol® will benefit the development of other generic or innovative microspheres.