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  • Molecular Diversity Preservation International  (2)
  • 1
    Publication Date: 2020-09-23
    Description: We compared the immediate effects of a cool-down strategy including an inverted body position (IBP: continuous 30-s alternations of supine and IBP) after a short period of an intense treadmill run with active (walking) and passive (seated) methods. Fifteen healthy subjects (22 years, 172 cm, 67 kg) completed three cool-down conditions (in a counterbalanced order) followed by a 5-min static stretch on three separate days. Heart rate, energy expenditure, blood lactate concentration, fatigue perception, and circumference of thighs and calves were recorded at pre- and post-run at 0, 5, 10, 20, and 30 min. At 5 min post-run, subjects performing the IBP condition showed (1) a 22% slower heart rate (p 〈 0.0001, ES = 2.52) and 14% lower energy expenditure (p = 0.01, ES = 0.48) than in the active condition, and (2) a 23% lower blood lactate than in the passive condition (p = 0.001, ES = 0.82). Fatigue perception and circumferences of thighs and calves did not differ between the conditions at any time point (F10,238 〈 0.96, p 〈 0.99 for all tests). IBP appears to produce an effect similar to that of an active cool-down in blood lactate removal with less energy expenditure. This cool-down strategy is recommended for tournament sporting events with short breaks between matches, such as Taekwondo, Judo, and wrestling.
    Electronic ISSN: 2076-3417
    Topics: Natural Sciences in General
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  • 2
    Publication Date: 2021-09-21
    Description: Carboxymethyl cellulose (CMC)-based hydrogels are generally superabsorbent and biocompatible, but their low mechanical strength limits their application. To overcome these drawbacks, we used bacterial succinoglycan (SG), a biocompatible natural polysaccharide, as a double crosslinking strategy to produce novel interpenetrating polymer network (IPN) hydrogels in a non-bead form. These new SG/CMC-based IPN hydrogels significantly increased the mechanical strength while maintaining the characteristic superabsorbent property of CMC-based hydrogels. The SG/CMC gels exhibited an 8.5-fold improvement in compressive stress and up to a 6.5-fold higher storage modulus (G′) at the same strain compared to the CMC alone gels. Furthermore, SG/CMC gels not only showed pH-controlled drug release for 5-fluorouracil but also did not show any cytotoxicity to HEK-293 cells. This suggests that SG/CMC hydrogels could be used as future biomedical biomaterials for drug delivery.
    Electronic ISSN: 2073-4360
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
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