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  • Molecular Diversity Preservation International  (1)
  • München : Verlag Franz Vahlen  (1)
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  • 1
    Monograph available for loan
    Monograph available for loan
    Nutzen-Kosten-Analyse (2011)
    München : Verlag Franz Vahlen
    Details Availability
    Call number: PIK B 541-20-93973
    Type of Medium: Monograph available for loan
    Pages: XIV, 217 Seiten , Diagramme
    Edition: 3., vollständig überarbeitete Auflage
    ISBN: 3800634120 (Pb.) , 9783800634125 (Pb.) , 9783800644759 (electronic)
    Series Statement: Vahlens-Kurzlehrbücher
    URL: http://www.gbv.de/dms/weimar/toc/523594119_toc.pdf
    URL: Inhaltsverzeichnis
    Language: German
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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    Pluripotent Stem Cell-Based Models: A Peephole into Virus Infections during Early Pregnancy (2020)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2020-02-26
    Description: The rubella virus (RV) was the first virus shown to be teratogenic in humans. The wealth of data on the clinical symptoms associated with congenital rubella syndrome is in stark contrast to an incomplete understanding of the forces leading to the teratogenic alterations in humans. This applies not only to RV, but also to congenital viral infections in general and includes (1) the mode of vertical transmission, even at early gestation, (2) the possible involvement of inflammation as a consequence of an activated innate immune response, and (3) the underlying molecular and cellular alterations. With the progress made in the development of pluripotent stem cell-based models including organoids and embryoids, it is now possible to assess congenital virus infections on a mechanistic level. Moreover, antiviral treatment options can be validated, and newly emerging viruses with a potential impact on human embryonal development, such as that recently reflected by the Zika virus (ZIKV), can be characterized. Here, we discuss human cytomegalovirus (HCMV) and ZIKV in comparison to RV as viruses with well-known congenital pathologies and highlight their analysis on current models for the early phase of human development. This includes the implications of their genetic variability and, as such, virus strain-specific properties for their use as archetype models for congenital virus infections. In this review, we will discuss the use of induced pluripotent stem cells (iPSC) and derived organoid systems for the study of congenital virus infections with a focus on their prominent aetiologies, HCMV, ZIKV, and RV. Their assessment on these models will provide valuable information on how human development is impaired by virus infections; it will also add new insights into the normal progression of human development through the analysis of developmental pathways in the context of virus-induced alterations. These are exciting perspectives for both developmental biology and congenital virology.
    Electronic ISSN: 2073-4409
    Topics: Biology
    Published by Molecular Diversity Preservation International
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