Publication Date:
2014-07-11
Description:
Article Abnormal accumulation of the RNA-binding protein FUS and mutations within the FUS gene have been found in association with amyotrophic lateral sclerosis (ALS). Here, Dini Modigliani et al. uncover a FUS regulatory circuit that implicates the microRNAs miR-141 and miR-200a in a feedback loop disrupted by an ALS-associated mutation. Nature Communications doi: 10.1038/ncomms5335 Authors: Stefano Dini Modigliani, Mariangela Morlando, Lorenzo Errichelli, Mario Sabatelli, Irene Bozzoni
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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