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  • Oxford University Press  (2)
  • Mineralogical Society of Great Britain and Ireland  (1)
  • 1
    Publication Date: 2014-04-11
    Description: In principle, the installation of emissions abatement technology (otherwise known as scrubbers) on ships would reduce air pollution and premature deaths from disease and allow vessels to save costs by continuing to burn cheap high-sulphur residual fuel oil. But very few scrubbers have been installed. A recent House of Commons Select Committee Inquiry was unable to decide between the competing technical claims of scrubber manufacturers and ship operators, over whether scrubber technology was sufficiently ‘mature’ for present installation. From the perspective of science and technology studies, this paper draws on interviews with stakeholders and written and oral evidence to the committee to argue that this was a dispute, which foregrounded technical arguments for investment decisions that were actually being taken on economic grounds. Where scientific/technical closure is a matter of communal understanding rather than technical demonstration, technical doubt can be used instrumentally for economic reasons to delay closure.
    Print ISSN: 0302-3427
    Electronic ISSN: 1471-5430
    Topics: Nature of Science, Research, Systems of Higher Education, Museum Science
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  • 2
    Publication Date: 2015-11-05
    Description: : When performing DNA sequencing to diagnose affected individuals with monogenic forms of rare diseases, accurate attribution of causality to detected variants is imperative but imperfect. Even if a gene has variants already known to cause a disease, rare disruptive variants predicted to be causal are not always so, mainly due to imperfect ability to predict the pathogenicity of variants. Existing population-scale sequence resources such as 1000 Genomes are useful to quantify the ‘background prevalence’ of an unaffected individual being falsely predicted to carry causal variants. We developed GeneVetter to allow users to quantify the ‘background prevalence’ of subjects with predicted causal variants within specific genes under user-specified filtering parameters. GeneVetter helps quantify uncertainty in monogenic diagnosis and design genetic studies with support for power and sample size calculations for specific genes with specific filtering criteria. GeneVetter also allows users to analyze their own sequence data without sending genotype information over the Internet. Overall, GeneVetter is an interactive web tool that facilitates quantifying and accounting for the background prevalence of predicted pathogenic variants in a population. Availability and Implementation: GeneVetter is available at http://genevetter.org/ Contact: mgsamps@med.umich.edu or hmkang@umich.edu Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
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  • 3
    Publication Date: 2005-10-01
    Description: Our recent discovery of hazardous concentrations of arsenic in shallow sedimentary aquifers in Cambodia raises the spectre of future deleterious health impacts on a population that, particularly in non-urban areas, extensively use untreated groundwater as a source of drinking water and, in some instances, as irrigation water. We present here small-scale hazard maps for arsenic in shallow Cambodian groundwaters based on 〉1000 groundwater samples analysed in the Manchester Analytical Geochemistry Unit and elsewhere. Key indicators for hazardous concentrations of arsenic in Cambodian groundwaters include: (1) well depths greater than 16 m; (2) Holocene host sediments; and (3) proximity to major modern channels of the Mekong (and its distributary the Bassac). However, high-arsenic well waters are also commonly found in wells not exhibiting these key characteristics, notably in some shallower Holocene wells, and in wells drilled into older Quaternary and Neogene sediments.It is emphasized that the maps and tables presented are most useful for identifying current regional trends in groundwater arsenic hazard and that their use for predicting arsenic concentrations in individual wells, for example for the purposes of well switching, is not recommended, particularly because of the lack of sufficient data (especially at depths 〉80 m) and because, as in Bangladesh and West Bengal, there is considerable heterogeneity of groundwater arsenic concentrations on a scale of metres to hundreds of metres. We have insufficient data at this time to determine unequivocally whether or not arsenic concentrations are increasing in shallow Cambodian groundwaters as a result of groundwater-abstraction activities.
    Print ISSN: 0026-461X
    Electronic ISSN: 1471-8022
    Topics: Geosciences
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