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  • Macmillan Magazines Ltd.  (1)
  • Oxford University Press  (1)
  • 1
    Electronic Resource
    Electronic Resource
    How the brain learns to see objects and faces in an impoverished context (1997)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 389 (1997), S. 596-599 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A degraded image of an object or face, which appearsmeaningless when seen for the first time, is easily recognizableafter viewing an undegraded version of the same image. The neural mechanisms by whichthis form of rapid perceptual learning facilitates perception are notwell understood. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/39309
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    Paper (German National Licenses)
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    Distal chromatin structure influences local nucleosome positions and gene expression (2012)
    Oxford University Press
    Details
    Publication Date: 2012-05-13
    Description: The positions of nucleosomes across the genome influence several cellular processes, including gene transcription. However, our understanding of the factors dictating where nucleosomes are located and how this affects gene regulation is still limited. Here, we perform an extensive in vivo study to investigate the influence of the neighboring chromatin structure on local nucleosome positioning and gene expression. Using truncated versions of the Saccharomyces cerevisiae URA3 gene, we show that nucleosome positions in the URA3 promoter are at least partly determined by the local DNA sequence, with so-called ‘antinucleosomal elements’ like poly(dA:dT) tracts being key determinants of nucleosome positions. In addition, we show that changes in the nucleosome positions in the URA3 promoter strongly affect the promoter activity. Most interestingly, in addition to demonstrating the effect of the local DNA sequence, our study provides novel in vivo evidence that nucleosome positions are also affected by the position of neighboring nucleosomes. Nucleosome structure may therefore be an important selective force for conservation of gene order on a chromosome, because relocating a gene to another genomic position (where the positions of neighboring nucleosomes are different from the original locus) can have dramatic consequences for the gene's nucleosome structure and thus its expression.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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