ALBERT

Description: Since 2008, the world’s largest blooms of the green macroalgae, Ulva prolifera, have occurred every summer in the Yellow Sea, posing the question of whether these macroalgal blooms (MABs) have changed the phytoplankton biomass due to their perturbations of nutrient dynamics. We have attempted to address this question using long-term Moderate Resolution Imaging Spectroradiometer (MODIS) observations. A new MODIS monthly time-series of chlorophyll-a concentrations (Chl-a, an index of phytoplankton biomass) was generated after removing the macroalgae-contaminated pixels that were characterized by unexpectedly high values in the daily Chl-a products. Compared with Chl-a during July of 2002–2006 (the pre-MAB period), Chl-a during July of 2008–2012 (the MAB period) exhibited significant increases in the offshore Yellow Sea waters (rich in macroalgae), with mean Chl-a increased by 98% from 0.64 µg/L to 1.26 µg/L in the study region. In contrast, no significant Chl-a changes were observed during June between the two periods. After analyzing sea surface temperature, photosynthetically available radiation, and nutrient availability, we speculate that the observed Chl-a changes are due to nutrient competition between macroalgae and phytoplankton: during the MAB period, the fast-growing macroalgae would uptake the increased nutrients from the origin of Jiangsu Shoal; thus, the nutrients available to phytoplankton were reduced, leading to no apparent increases in biomass in the offshore Yellow Sea in June.

Description: Differences in expression of drug response-related genes contribute to inter-individual variation in drugs’ biological effects. MicroRNAs (miRNAs) are small noncoding RNAs emerging as new players in epigenetic regulation of gene expression at post-transcriptional level. MiRNAs regulate the expression of genes involved in drug metabolism, drug transportation, drug targets and downstream signal molecules directly or indirectly. MiRNA polymorphisms, the genetic variations affecting miRNA expression and/or miRNA-mRNA interaction, provide a new insight into the understanding of inter-individual difference in drug response. Here, we provide an overview of the recent progress in miRNAs mediated regulation of biotransformation enzymes, drug transporters, and nuclear receptors. We also describe the implications of miRNA polymorphisms in cancer chemotherapy response.

Description: Energies, Vol. 11, Pages 1287: Optimized Daily Dispatching Strategy of Building- Integrated Energy Systems Considering Vehicle to Grid Technology and Room Temperature Control Energies doi: 10.3390/en11051287 Authors: Zesen Wang Yanmei Tang Xiao Chen Xiangyang Men Jun Cao Haifeng Wang With the development of vehicle-to-grid (V2G) technology, electric vehicles (EVs) are not only a promising transportation solution, but also can be used as mobile energy storage and spinning reserves, which play an important role in building-integrated energy systems (BIESs) and can further promote energy efficiency. Considering the space-time characteristics of EVs and the room temperature demand, this study establishes a planning model using V2G technology to minimize daily dispatch cost. Four kinds of control modes were proposed, combining the technology of the resident-owned and staff-owned EVs, in combination with the internal heating and power supply system. In this paper, the operating state of the system and the interaction of the equipment are analyzed under different charging and discharging control modes of EVs. The economics of the microgrid of the comprehensive energy building under four control modes are also discussed. Simulation results indicate that the combined control mode of residential vehicle and office vehicle is optimal for building an integrated energy microgrid, and the room temperature requirements can also be used as an important income source for building the microgrid.

Description: The hotel industry in China has experienced rapid growth in the past ten years and made a considerable contribution to the global tourism economy. This paper focuses on the energy performance of hotel buildings in Lijiang, China. Hotel characteristics, daily operational data, and energy use data were collected by carrying out a survey of 24 hotels. The average annual energy use intensity (EUI) of four-, three-, two-, and one-star rated hotels was 180.8 kWh/m2, 113.3 kWh/m2, 74.2 kWh/m2, and 70.2 kWh/m2, respectively. Electricity, as the dominant energy source, accounted for 81% of total energy consumption and was used in the operation of air conditioning, lighting, heating, etc. Pearson correlations between EUI showed that hotel star rating, number of guest rooms, room revenue, and number of workers gave a reasonably strong correlation. A regression-based benchmarking model was established to predict EUI, and a standardization process of EUI was illustrated by statistical analysis.

Description: A graphene-based long-period fiber grating (LPFG) surface plasmon resonance (SPR) sensor is proposed. A monolayer of graphene is coated onto the Ag film surface of the LPFG SPR sensor, which increases the intensity of the evanescent field on the surface of the fiber and thereby enhances the interaction between the SPR wave and molecules. Such features significantly improve the sensitivity of the sensor. The experimental results demonstrate that the sensitivity of the graphene-based LPFG SPR sensor can reach 0.344 nm%−1 for methane, which is improved 2.96 and 1.31 times with respect to the traditional LPFG sensor and Ag-coated LPFG SPR sensor, respectively. Meanwhile, the graphene-based LPFG SPR sensor exhibits excellent response characteristics and repeatability. Such a SPR sensing scheme offers a promising platform to achieve high sensitivity for gas-sensing applications.

Description: Forests, Vol. 9, Pages 24: Increased Vegetation Greenness Aggravates Water Conflicts during Lasting and Intensifying Drought in the Poyang Lake Watershed, China Forests doi: 10.3390/f9010024 Authors: Lin-Ling Tang Xiao-Bin Cai Wei-Shu Gong Jian-Zhong Lu Xiao-Ling Chen Qian Lei Gong-Liang Yu An increase in vegetation greenness can improve ecosystem productivity, but also reduce the water supply, creating the potential for conflicting water demands between ecosystems and humans. This problem has been well-assessed and is most evident in dry environments. However, in humid regions, the potential effects of vegetation greenness on water yields under drought conditions are not well understood. To address this gap, we focused on the Poyang Lake watershed in the humid region of southern China. Based on the Standardized Precipitation Evapotranspiration Index and a satellite-derived leaf area index dataset during the growing seasons of 1984 to 2013, several typical dry growing seasons were selected as the study conditions. An existing Water Supply Stress Index model was modified to investigate how the changes in vegetation greenness affected water yield and to explore potentially conflicting water demands between ecosystems and humans under drought conditions. Our results showed that an increase of 20–80% in vegetation greenness generally resulted in a reduction of 3–27% in water yield under drought conditions. Large reductions in water yield mainly were observed in forested areas due to large increases in forest greenness. Moreover, increased vegetation greenness caused a 2 to 3 times greater reduction in water yield during continuing and intensifying droughts than during a short moderate drought period. Thus, in this study, during continuing and intensifying droughts, increased vegetation greenness can cause or aggravate water conflicts in sub-watersheds with high forest cover and high human water demands. Therefore, given the increasing frequency of extreme climatic events, afforestation with a targeted approach should be implemented as it would provide the most benefits. In addition, selective harvesting in forested areas with high density could be an effective strategy to maintain water supply in humid regions.

Description: Clopidogrel has significantly reduced the incidence of recurrent atherothrombotic events in patients with acute coronary syndrome (ACS) and in those undergoing percutaneous coronary intervention (PCI). However, recurrence events still remain, which may be partly due to inadequate platelet inhibition by standard clopidogrel therapy. Genetic polymorphisms involved in clopidogrel’s absorption, metabolism, and the P2Y12 receptor may interfere with its antiplatelet activity. Recent evidence indicated that epigenetic modification may also affect clopidogrel response. In addition, non-genetic factors such as demographics, disease complications, and drug-drug interactions can impair the antiplatelet effect of clopidogrel. The identification of factors contributing to the variation in clopidogrel response is needed to improve platelet inhibition and to reduce risk for cardiovascular events. This review encompasses the most recent updates on factors influencing pharmacokinetic and pharmacodynamic responses to clopidogrel.

Description: Left ventricular remodeling is an essential risk factor contributing to the pathogenesis of chronic heart failure (CHF). Basigin (BSG) promotes cardiovascular inflammation and myocardial remodeling processes by induction of extracellular matrix metalloproteinases and inflammatory cytokines. BSG rs8259 polymorphism was associated with BSG expression and risk of acute coronary syndrome. Therefore, we investigated whether rs8259 polymorphism contributes to risk and prognosis of CHF in Chinese patients. In total 922 adult patients with CHF and 1107 matched healthy controls were enrolled. BSG rs8259 polymorphism was genotyped using PCR-restriction fragment length polymorphism. Whole blood BSG mRNA expression data from Genotype-Tissue Expression project was accessed. Evaluation of follow-up data was performed in only 15.2% (140) of the patients with CHF. BSG rs8259 TT genotype was associated with a decreased risk of CHF (OR = 0.83, 95% CI = 0.72–0.96, p = 0.010), especially in patients with hypertension (OR = 0.80, 95% CI = 0.68–0.95, p = 0.011) and coronary heart disease (OR = 0.81, 95% CI = 0.69–0.96, p = 0.013) after adjustment for multiple cardiovascular risk factors. Rs8259 T allele was associated with decreased BSG mRNA in whole blood from 338 healthy normal donors (p = 1.31 × 10−6). However, rs8259 polymorphism failed to exhibit an association with cardiovascular mortality (p = 0.283). BSG rs8259 polymorphism may contribute to decreased risk of CHF in a Chinese Han population.

Description: Embankments are common structures along rivers or lakes in riparian zones in plain areas. They should have natural slopes instead of slopes covered by concrete or other hard materials, in order to rebuild sustainable ecosystems for riparian zones. This study was conducted to evaluate the effects of vegetative slopes on water flow and pollutant transport through the embankments. Three embankments with different slope treatments (a bare slope, a slope covered in centipede grass, a slope covered in tall fescue) were examined, and three inflow applications of pollute water with different concentration of total nitrogen (TN) and total phosphorus (TP) used to simulate different agricultural non-point pollution levels. The results showed that the water flux rates of the three embankments were relatively stable under all inflow events, and almost all values were higher than 80%. The embankments with vegetative slopes had better nitrogen removal than the bare slope under all events, and the one with tall fescue slope was best, but the benefits of vegetative slopes decreased with increasing inflow concentration. Moreover, there were no significant differences between the embankments on phosphorus removal, for which the reductions were all high (above 90%) with most loads remaining in the front third of embankment bodies. Overall, the embankments with vegetative slopes had positive effects on water exchange and reducing non-point pollutant into lake or river water, which provides a quantitative scientific basis for the actual layout of lakeshores.