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  • Books  (6)
  • anticancer  (3)
  • bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society  (3)
  • MDPI - Multidisciplinary Digital Publishing Institute  (6)
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  • Books  (6)
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  • MDPI - Multidisciplinary Digital Publishing Institute  (6)
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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: We invite you to contribute to a Special Issue of Nutrients, entitled “Dietary Supplements”. The purpose of this Special Issue is to advance dietary supplement science by presenting commissioned overviews on four nutrients of particular current interest and controversy: Vitamin D, iodine, iron, and omega-3 fatty acids. To supplement these contributions, we welcome the submission of manuscripts describing original research or providing systematic reviews related to various issues in dietary supplement science. Manuscripts across a broad range of topics will be considered, but we are particularly interested in manuscripts that address the following areas: • Health effects, both positive and negative, of single nutrients, such as vitamin D, iodine, iron, and omega-3 fatty acids, with an emphasis on human studies. • Human clinical trials of dietary supplement use • Motivations for and prevalence of the use of dietary supplements • Mechanisms of action of nutrients and other bioactive components of dietary supplements. • Biomarkers of nutritional status, especially those measured in human samples. • Development and application of analytical tools for the measurement of bioactive components of dietary supplements. • Databases of dietary supplements' composition for use in improving the assessment of nutrient intake and of the exposure to ingredients present in these products in human populations.
    Keywords: TX341-641 ; food supplements ; bioactives ; dietary supplements ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society
    Language: English
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Diet and lifestyle choices can substantially predispose an individual to, or protect against, many age- and obesity-related chronic diseases. According to the NIH Office of Dietary Supplements, dietary bioactives arecompounds in foodsnot needed for basic human nutrition but responsible for changes in health status.1 These compounds are safe at normal food consumption levels (e.g., anthocyanins in berries) and their biological activities may come from a single compound (e.g., lutein in spinach) or a class of compounds (e.g., avenanthramides in oats) even if the exact identity and composition are unknown. Bioactive compounds of plants; can vary significantly in their ratios and relative concentrations depending onfactors such as cultivation, soil, altitude, and weather conditions. Substantial scientific evidence is available for some health promoting phytochemicals, such as dose-response relations, for performance and/or reduction in the risk of chronic disease. However, several limitations relating to absorption, distribution, metabolism and excretion of many dietary bioactives still exist and must be better understood This Special Issue compiles recent discoveries that advance our understanding of how dietary bioactive, particularly from fruits and vegetables, influence long-term health maintenance and disease prevention.
    Keywords: TX341-641 ; non-essential nutrient ; dietary bioactives ; disease prevention ; fruits ; vegetables ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society
    Language: English
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  • 3
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: This book will cover topics related to the preparation and use of heterogeneous catalytic systems for the transformation of renewable sources, as well as of materials deriving from agro-industrial wastes and by-products. At the same time, the ever-increasing importance of bioproducts, due to the acceptance and request of consumers, makes the upgrade of biomass into chemicals and materials not only an environmental issue, but also an economical advantage.
    Keywords: QH301-705.5 ; Q1-390 ; isoselenourea ; malignant ; chemotherapeutics ; epigenetics ; antitumor activity ; methylseleninic acid ; mTOR inhibitors ; tumor heterogeneity ; hypoxia ; ER stress ; melanoma ; EMT ; lipid peroxidation ; immune evasion ; hypoxia-inducible factors (HIFs) ; selenium-binding protein 1 ; glutathione ; DNA damage ; hSP56 ; apoptosis ; tocopherol ; anticancer ; viability ; SELENBP1 ; selenium ; clear-cell renal cell carcinoma microRNAs ; SBP1 ; entosis ; PD-L1 ; miRNA ; cancer stem cells ; cell plasticity ; disease ; clear cell renal cell carcinoma ; HIF ; head and neck cancer ; selenium species ; VEGF ; STAT3 ; hypoxia-inducible factor ; methylselenocysteine ; anticancer agent ; Se-containing nanoparticles ; DNA damage and repair ; radiation ; seleno-l-methionine ; cancer ; tumor microenvironment ; methylselenoesters ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Accumulating evidence suggests that not all obese subjects are at increased cardiometabolic risk and that the “metabolically healthy obese” phenotype may exist in the absence of metabolic abnormalities. Limited data regards the determinants of metabolically healthy obesity exist, particularly in relation to genetics, dietary and lifestyle behaviours. In light of the current obesity epidemic, it is clear that current “one size fits all” approaches to tackle obesity are largely unsuccessful. Whether dietary, lifestyle and/or therapeutic interventions, based on stratification of obese individuals according to their metabolic health phenotype, are more effective remains to be seen, with limited and conflicting data available. This book includes original research articles and reviews of the scientific literature that contribute to our understanding of the role of clinical, biological, genetic, and environmental factors in metabolically healthy and unhealthy obesity.
    Keywords: TX341-641 ; Inflammation: Intervention ; Nutrition ; Physical activity ; Metabolically healthy obesity ; Life course ; Mortality ; Genetics ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites for therapeutic application. The Special Issue contains 16 articles reporting relevant experimental results, and an overview of bioactive secondary metabolites, their biological effects, and new methodologies that improve and accelerate the process of obtained lead compounds with regard to new drug development. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this Special Issue.
    Keywords: QD1-999 ; Q1-390 ; antitumor ; triterpenoids ; seaweeds ; diterpenes ; Boswellia ; antioxidant activity ; antiplasmodial ; Maytenus chiapensis ; phenolic derivatives ; secondary metabolites ; medicinal applications ; Malus x domestica ; pectin ; cytotoxic activity ; xanthine oxidase ; phytochemistry ; antioxidant ; Scabiosa ; sugars ; sargaquinoic acid ; pentacyclic triterpenoids ; analysis ; antimicrobial and anticancer activity ; iridoids ; Tuscany ; GC-MS ; (-)-rabdosiin ; kratom ; plant defense ; cembranoids ; tingenone ; deoxypodophyllotoxin ; anticancer ; pristimerin ; inflammation ; boswellic acids ; plants ; anti-inflammatory ; legalization ; Mitragyna speciosa ; Ocimum sanctum ; cordycepin ; cytotoxic ; medicine ; Artemisia species ; antimicrobial activity ; lignans ; Artemisia vachanica ; Cordyceps militaris ; frankincense ; ancient varieties ; sargahydroquinoic acid ; Tajikistan ; antiSMASH ; ABTS ; polyphenols ; therapeutics ; infectious diseases ; antibacterial ; nutraceutics ; total phenolics ; LC-MS/MS ; innate immunity ; HPLC-PAD ; sarganaphthoquinoic acid ; biosynthetic gene clusters ; DPPH ; EGCG ; cneorubenoids ; PPAR-? ; bowel diseases ; amentoflavone ; molecular docking ; sargachromenoic acid ; cannabinoids ; flavonoids ; essential oils ; TCM ; HPLC-PDA ; ascorbic acid ; antioxidants ; Lamiaceae ; nanoemulsion ; malaria ; therapeutic uses ; quinonemethide triterpenoids ; artemisinin ; natural products ; biological activities ; FRAP ; toxicology ; defensins ; Celastraceae ; cannabis ; vector control ; Juniperus ; analytical determination ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: The past decades have seen major developments in the understanding of the cellular and molecular biology of cancer. Significant progress has been achieved regarding long-term survival for the patients of many cancers with the use of tamoxifen for treatment of breast cancer, treatment of chronic myeloid leukaemia with imatinib, and the success of biological drugs. The transition from cytotoxic chemotherapy to targeted cancer drug discovery and development has resulted in an increasing selection of tools available to oncologists. In this Special Issue of Pharmaceuticals, we highlight the opportunities and challenges in the discovery and design of innovative cancer therapies, novel small-molecule cancer drugs and antibody–drug conjugates, with articles covering a variety of anticancer therapies and potential relevant disease states and applications. Significant efforts are being made to develop and improve cancer treatments and to translate basic research findings into clinical use, resulting in improvements in survival rates and quality of life for cancer patients. We demonstrate the possibilities and scope for future research in these areas and also highlight the challenges faced by scientists in the area of anticancer drug development leading to improved targeted treatments and better survival rates for cancer patients.
    Keywords: QD1-999 ; Q1-390 ; graphene oxide ; indole ; androgens ; cyclooxygenase-2 ; cyclooxygenase-1 ; heteropolysaccharide ; drug conjugation ; drug delivery ; ellipticine ; chemical linker ; oesophageal cancer ; antiproliferative activity ; topoisomerase II ; ?-lactam ; DSD ; antibody ; topoisomerase inhibitors ; magnetic targeting ; cisplatin resistance ; steroidogenesis ; [18F]FDG PET/CT ; heterocyclic chemistry ; dehydroepiandrosterone ; antimitotic ; 3-vinylazetidin-2-ones ; glioblastoma ; and cancer therapy ; intestinal mucositis ; Combretastatin A-4 ; metabolism ; anti-cancer drugs ; maghemite ; COX-1 inhibitor ; anticancer ; CYP17A1 ; conjugate and hybrid drugs ; inflammation ; snticancer drugs ; P450c17 ; tumorigenesis ; cisplatin ; biomarker profiling ; cancer drug design ; tubulin ; cytochrome P450 ; 5-fluorouracil ; prostate cancer ; abiraterone ; NCI screen ; radiation ; cancer immunotherapy ; microtubule targeted drugs ; cancer ; treatment resistance ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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