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  • 1
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    DNA Replication Stress (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-05
    Description: This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.
    Keywords: QH301-705.5 ; Q1-390 ; Werner Syndrome ; n/a ; A549 cells ; epigenetic ; neurodegeneration ; Genome integrity ; adaptation ; cellular senescence ; genome instability ; Werner Syndrome Protein ; lipofuscin ; cell cycle checkpoints ; exonuclease 1 ; template-switching ; energy metabolism ; mutation frequency ; DNA replication ; fork regression ; motor neuron disease ; Microsatellites ; Alzheimer’s disease ; chromatin remodeler ; repair of DNA damage ; AP site analogue ; mutagens ; replication timing ; Thermococcus eurythermalis ; nucleolar stress ; gene expression ; mutations spectra ; origin firing ; Fanconi Anemia ; superfamily 2 ATPase ; DNA translocation ; DNA repair ; SSB signaling ; homologous recombination ; common fragile sites ; 8-chloro-adenosine ; replication ; genome stability ; mutagenicity ; fork reversal ; multiple sclerosis ; non-B DNA ; protein stability ; heterogeneity ; ubiquitin ; SenTraGorTM (GL13) ; replication restart ; EdU ; ?-arrestin ; NER ; aging ; SSB end resection ; oxidative stress ; ATR ; dormant origins ; R loops ; DNA damage response ; Difficult-to-Replicate Sequences ; DNA double-strand repair ; endonuclease IV ; ALS ; double strand break repair ; premature aging ; replication stress ; EXO1 ; POL? ; translesion synthesis ; strand displacements ; G2-arrest ; DNA replication pattern ; SSB repair ; genome integrity ; G protein-coupled receptor kinase interacting protein 2 (GIT2) ; MMR ; replicative stress ; senolytics ; spacer ; interactome ; ATR-Chk1 DDR pathway ; C9orf72 ; replication fork restart ; translesion DNA synthesis ; DNA damage ; mismatch repair ; DNA replication stress ; DNA helicase ; Polymerase kappa ; DNA fiber assay ; H1299 cells ; TLS ; APE2 ; ageing ; cell death ; chromosome ; TopBP1 ; barley ; clock proteins ; post-translational modification ; 8-oxoG ; S phase ; ataxia telangiectasia mutated (ATM) ; G protein-coupled receptor (GPCR) ; Polymerase eta ; cancer ; G protein-coupled receptor kinase (GRK) ; helicase ; genomic instability ; Parkinson’s disease ; nucleotide excision repair ; SupF ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 2
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    Changing Land Use, Changing Livelihoods: Smallholders Today (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-20
    Description: This book brings together eleven works by scholars within and beyond geography, to argue the case for a continued engagement with smallholder agricultural studies. The research detailed is largely empirical and draws on a wide spectrum of mixed qualitative and quantitative methodologies. The case studies cover a range of geographic locations, including Brazil, Burkina Faso, South Africa, Botswana, Malawi, Madagascar, Vietnam, and the USA, with greatest emphasis in sub-Saharan Africa. Key themes that emerge include the structural and relative nature of "smallholder" as a category, the dynamic reality of smallholder livelihoods, the importance of smallholder farming and land-use practices to questions of environmental sustainability, and the challenges of vulnerability and adaptation in contemporary human–environment systems. Overall these studies show that smallholder studies are more pertinent than ever, especially in the face of finite resources and global environmental change.
    Keywords: HF1-6182 ; S1-972 ; agroecology ; adaptation ; land tenure ; households ; forests ; sustainability ; vulnerability and resilience ; agriculture ; smallholders ; land management practices ; production chains ; livelihoods ; diversification ; poverty ; climate change ; bic Book Industry Communication::K Economics, finance, business & management::KF Finance & accounting::KFF Finance::KFFK Banking
    Language: English
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  • 3
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    Water Intake, Body Water Regulation and Health (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-05
    Description: The purpose of this Special Issue, “Water Intake, Body Water Regulation, and Health”, is to present novel reviews and experimental data regarding hydration physiology and its implication in overall health. Water has previously been dubbed the forgotten nutrient due to humans’ and animals’ ability to subsist seemingly unchanged across a wide range of daily water intakes. However, with the introduction of stressors such as exercise, diseased states, and/or chronic high or low water intake, the homeostatic signals related to body water regulation can influence organ and whole-body health. This Special Issue will discuss water intake, the scientific rationale surrounding the U.S. and European water intake guidelines, homeostatic mechanisms, diseases related to dysfunction of water regulation, and differences in the volume and the vehicle in which the water is contained (i.e., plain water versus mixed beverages) on water intake during and following exercise. The aim is to continue discussion surrounding water, the previously forgotten nutrient, and highlight the importance of water in daily life.
    Keywords: QH301-705.5 ; Q1-390 ; TX341-641 ; n/a ; modeling ; adaptation ; pollution ; perception ; heat stress ; assessment ; body composition ; polydipsia ; environmental stressors ; deuterium ; children ; water-electrolyte balance ; dehydration ; big data ; obesity ; climate change ; hydration factor and Hispanic Americans ; water ; thermoregulation ; rehydration ; fluid replacement ; hydration ; chronic disease ; acute kidney injury ; chronic kidney disease ; blood pressure regulation ; exercise ; electrolytes ; euhydration ; database ; water intake ; drinking water ; vascular function ; skin blood flow ; sympathetic nervous system ; oral rehydration therapy ; water restriction ; ultraviolet radiation ; hyponatremia ; DNA ; NHANES ; aging ; sweating ; hypohydration ; body water ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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