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  • Books  (5)
  • R5-920  (5)
  • ASTROPHYSICS
  • Chemistry
  • SPACE VEHICLES
  • STRUCTURAL MECHANICS
  • MDPI - Multidisciplinary Digital Publishing Institute  (5)
  • 1
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    Biological Activities of Alkaloids: From Toxicology to Pharmacology (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2023-12-21
    Description: Natural products are increasingly attracting attention from both basic and applied science. Plant secondary metabolites, especially alkaloids, are receiving interest from a wide range of researchers due to their biological activity. They are produced to protect plants from diseases and herbivores. Therefore, they reveal a toxic activity that affects organisms at various levels of biological organization. A growing amount of research is proving their antimicrobial, antifungal, insecticidal, and anticancer activities. That makes them applicable in various fields from medicine, to pharmacology, veterinary, and toxicology, to crop protection. This Special Issue of Toxins, “Biological Activities of Alkaloids: From Toxicology to Pharmacology"", collects 15 manuscripts describing the ecological, biological, pharmacological, and toxicological effects as well as structural and analytical aspects of plant alkaloids, their mode of action, and possible application in veterinary, medicine, and plant protection. These studies prove the potential for alkaloid application in various areas of science.
    Keywords: R5-920 ; RM1-950 ; leukemia ; n/a ; biodistribution ; glycoalkaloids ; insect heart ; Solanum melongena L. ; antibacterial ; alkaloid ; ?-carboline ; Ovarian cancer ; Chelidonium majus ; secondary metabolites ; lindoldhamine ; livestock ; insect ; chanoclavine ; bisbenzylisoquinoline alkaloid ; cytotoxic activity ; Staphylococcus aureus ; antioxidant ; acid-sensing ion channel subtype 1a ; malonylated form ; HPLC-DAD ; ergot alkaloids ; nociception ; macrophage ; Arecoline ; Macleaya cordata ; antifungal ; neuropathic pain ; Corydalis lutea ; antiviral ; Curine ; lung cancer cells ; lipopolysaccharide ; Epichloë ; Meconopsis cambrica ; Berberis thunbergii ; SRC ; Dicentra spectabilis ; apoptosis ; endophyte ; natural sources ; dehydrocrenatidine ; neutrophil ; EGFR ; anticancer ; solamargine ; berberine ; isoquinoline alkaloids ; natural products ; Radix Aconiti Lateralis preparations ; short-term and long-term usage ; inflammation ; acute toxicity ; Mahonia aquifolia ; Palmatine ; sanguinarine ; Rutidea parviflora ; voltage-gated sodium channels ; cytotoxicity ; toxicology ; malonyl-solamargine ; alkaloids ; acetylcholinesterase ; beetles ; Fumaria officinalis ; antimicrobial activity ; solasonine ; FAK ; plant secondary metabolites ; di-ester diterpenoid alkaloids ; mAchR3 ; subchronic feeding study ; mono-ester diterpenoid alkaloids ; Tenebrio molitor ; Apoptosis ; reproduction ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
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    Chronic and Recurrent Pain (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2023-12-21
    Description: For many years people assumed that children did not experience chronic pain. However, recent epidemiological studies show that chronic pain, defined as constant or recurrent pain lasting three months or longer, is common in childhood. Empirical studies have characterized chronic pain conditions including headaches, abdominal pain, chest pain, and musculoskeletal pains including fibromyalgia. These pain conditions are associated with school absence, emotional distress, disruption in family activities, and significantly reduced quality of life in both the affected child and their families. For some of these children, chronic pain persists from childhood into adulthood, causing substantial long-term personal and financial costs to the individual, society, and our health care systems. Despite the prevalence and serious consequences of pediatric chronic pain, it is still under-recognized and under-treated. Too often, chronic pain is treated as a symptom of something else, rather than as a separate condition requiring its own treatment. The goal of this Special Issue was to discuss recent advances in the understanding and treatment of pediatric chronic pain. The Special Issue Book contains 22 notable articles including original research, reviews, and commentaries. Together they provide an excellent overview of the field of chronic and recurrent pediatric pain as it stands in 2016–2017.
    Keywords: R5-920 ; Pediatrics ; Pain ; bic Book Industry Communication::M Medicine
    Language: English
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  • 3
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    Nutrition in Pregnancy - Volume II (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2023-12-21
    Description: Maternal nutrition during pregnancy is of considerable interest to women, their partners and their health care professionals. In developing countries, maternal undernutrition is a major concern. However, with the increased prevalence of abundant high calorie diets, their impact upon pregnancy outcome is of concern. In addition to the amount of nutrition available and its macronutrient composition within a diet, there is emerging evidence highlighting important roles for the lesser studied micronutrients. Added to this complexity is the distinction between maternal and fetal nutrition and the impact the placenta plays in nutrient metabolism and overall nutrient supply to the fetus. Together, these many variables contribute to placental development and function, fetal growth, and, where placental/fetal nutrition and growth is compromised, through poor maternal diet, and/or diet induced alterations in placental metabolism, the impact is dramatic and can lead to lifelong implications for the offspring. This Special Issue book aims to highlight research in many of these areas.
    Keywords: R5-920 ; maternal diet ; postnatal health ; fetal nutrition ; fetal growth ; Maternal nutrition ; bic Book Industry Communication::M Medicine
    Language: English
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  • 4
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    Influenza Virus and Vaccination (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: The influenza virus poses a threat to human health and is responsible for global epidemics every year. In addition to seasonal infections, influenza can cause occasional pandemics of great consequence when novel viruses are introduced into humans. Despite the implementation of comprehensive vaccination programs, influenza viruses continue to pose an important and unpredictable global public health threat. They are one of the most significant causes of morbidity and mortality each year and have a significant economic impact. In recent years, research has been conducted to find alternative approaches to influenza vaccine development, including the generation of universal vaccines. Notably, significant progress in the field of influenza infection, transmission, and immunity have contributed to our understanding of influenza biology, and to expanding the technological approaches for the generation of more efficient strategies against influenza infections. Moreover, highly remarkable developments have been made in the implementation of new methodologies to evaluate the efficiency of vaccines and improve them for use on domestic animals such as poultry, horses, dogs or pigs. This enables us to decrease the exposure of humans to potentially pandemic viruses. The articles in this Special Issue will address the importance of influenza to human health and the advances in influenza research that have led to the development of better therapeutics and vaccination strategies.
    Keywords: R5-920 ; RC581-607 ; heterosubtypic immunity of influenza ; master donor virus ; imprinting ; hemagglutinin ; universal vaccines ; pandemic ; adaptive immunity ; pregnant women ; innate immunity ; antibodies ; Influenza vaccine ; ARDS ; influenza A virus ; humoral response ; influenza vaccine ; original antigenic sin “OAS” ; germinal centers ; immunogenicity ; lung ; epitopes ; Influenza virus ; single nucleotide polymorphisms (SNPs) ; influenza virus ; protein microarray assay ; “universal” influenza vaccine ; vaccination ; influenza ; multiple dimensional assay (MDA) ; infection ; tissue resident ; memory ; vaccines ; CD4 T cell ; broad neutralizing antibody(bnAb) ; hemagglutinin (HA) of influenza virus ; original antigenic sin ; immune response ; morbidity ; T cell ; mPLEX-Flu assay ; Influenza A virus (IAV) ; virus–host interaction ; hemagglutin stalk ; memory B cells ; vaccine safety ; protection efficacy ; live attenuated influenza vaccine ; pediatrics ; vaccination rate ; bic Book Industry Communication::M Medicine
    Language: English
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  • 5
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    New Approaches for the Discovery of Pharmacologically-Active Natural Compounds (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: A major source of active compounds, natural products from different sources supply a large variety of molecules that have been approved for clinical use or used as the starting points of optimization programs. This book features nine papers (eight full articles and one review paper) written by more than 45 scientists from around the world. These papers illustrate the development and application of a broad range of computational and experimental techniques applied to natural product research. On behalf of the contributors to the book, our hope is that the research presented here contributes to advancements in the field, and encourages multidisciplinary teams, young scientists, and students to further advance in the discovery of pharmacologically-active natural compounds
    Keywords: R5-920 ; RM1-950 ; n/a ; immunoproteasome ; ginsenoside F1 ; visualization ; chemoinformatics ; soil microorganism ; molecular diversity ; web service ; epigenetics ; bioinsecticides ; Tibetan Plateau ; nanoparticles ; Py-GC/MS ; drug discovery ; consensus diversity plot ; chemical data set ; molecular interactions ; curcumin ; similarity maps ; Alzheimer’s disease ; proteasome inhibitors ; cyclodextrin glycosyltransferase (CGTase) ; classification ; squalene ; docking ; molecular docking ; cholestasis ; protein aggregation ; brain diseases ; structure–activity relationship ; flavonoids ; molecular fingerprints ; cyclodextrin glycosyltransferase ; random forest ; multitarget ; natural products ; inflammation ; natural product-likeness ; chemical space ; epi-informatics ; molecular dynamics ; machine learning ; systematic review ; phenylethanoid glycosides ; ?-glucosyl ginsenoside F1 ; alpine grassland ; Calceolaria ; marine diterpenoid ; Parkinson’s disease ; bic Book Industry Communication::M Medicine
    Language: English
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