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  • Books  (11)
  • QH301-705.5  (11)
  • MDPI - Multidisciplinary Digital Publishing Institute  (11)
  • Washington, DC : United States Gov. Print. Off.
  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.
    Keywords: QH301-705.5 ; Q1-390 ; HCP5 ; n/a ; camels ; MHC ; STK19 ; major histocompatibility complex ; human papillomavirus (HPV) ; T-cell receptor ; T1DGC ; bottleneck ; micro-mini-pigs ; life history ; computational analysis ; hepatocellular carcinoma ; phase ; Bactrian camel ; NSDK ; melanoma ; antigen ; autoimmune disease ; RD ; selection ; disease resistance ; autoimmunity ; ancestral haplotype ; Ski complex ; DXO ; high-throughput sequencing ; conservation genetics ; SVA ; lncRNA ; ankylosing spondylitis ; MHC genes ; viral peptides ; competing endogenous RNA (ceRNA) ; astrogliosis ; birds ; long-fragment super haplotype ; SNP ; RLR ; HLA polymorphism ; 5??3? RNA decay ; expression ; 3??5? mRNA turnover ; orthology ; long-read sequencing ; disease association ; dromedary ; polyomavirus ; MHC-II-associated sperm-egg recognition ; experimental medicine ; single nucleotide polymorphism (SNP) ; fish ; SKIV2L ; production trait ; molecular dynamics simulation ; Macaca fascicularis ; human endogenous retrovirus (HERV) ; concerted evolution ; polymorphism ; Old World camels ; MHC polymorphism ; protocol ; nonclassical ; gene duplication ; microglial reaction ; human leukocyte antigen-E ; SKI2W ; quantitative trait loci (QTL) studies ; antiviral immunity ; human immunodeficiency virus (HIV) ; founder effect ; giant panda ; domain movements ; BK virus ; promoter-proximal transcriptional pause ; type 1 diabetes (T1D) ; RP1 ; miR1236 ; KIR ; synaptic covering ; swine leukocyte antigen ; cynomolgus macaque ; HLA ; kidney transplantation ; ?2m knockout mice ; DOM3Z ; interferon ? ; ethnic populations in China ; ecology ; KIR–HLA pairs ; exosomes ; major histocompatibility complex (MHC) ; MHC-I-based mother-fetus recognition ; RNA quality control ; autoimmune diseases ; NELF-E ; haplotype ; genetic drift ; evolution ; nonhuman primate models ; HLA-B27 ; PNS/CNS interface ; risk genes ; pedigree ; MHC-I- and MHC-II-dependent inter-individual recognition ; regulation ; crested ibis ; reproductive performance ; nephropathy ; cancer ; nuclear kinase ; trichohepatoenteric syndrome ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.
    Keywords: QH301-705.5 ; Q1-390 ; Werner Syndrome ; n/a ; A549 cells ; epigenetic ; neurodegeneration ; Genome integrity ; adaptation ; cellular senescence ; genome instability ; Werner Syndrome Protein ; lipofuscin ; cell cycle checkpoints ; exonuclease 1 ; template-switching ; energy metabolism ; mutation frequency ; DNA replication ; fork regression ; motor neuron disease ; Microsatellites ; Alzheimer’s disease ; chromatin remodeler ; repair of DNA damage ; AP site analogue ; mutagens ; replication timing ; Thermococcus eurythermalis ; nucleolar stress ; gene expression ; mutations spectra ; origin firing ; Fanconi Anemia ; superfamily 2 ATPase ; DNA translocation ; DNA repair ; SSB signaling ; homologous recombination ; common fragile sites ; 8-chloro-adenosine ; replication ; genome stability ; mutagenicity ; fork reversal ; multiple sclerosis ; non-B DNA ; protein stability ; heterogeneity ; ubiquitin ; SenTraGorTM (GL13) ; replication restart ; EdU ; ?-arrestin ; NER ; aging ; SSB end resection ; oxidative stress ; ATR ; dormant origins ; R loops ; DNA damage response ; Difficult-to-Replicate Sequences ; DNA double-strand repair ; endonuclease IV ; ALS ; double strand break repair ; premature aging ; replication stress ; EXO1 ; POL? ; translesion synthesis ; strand displacements ; G2-arrest ; DNA replication pattern ; SSB repair ; genome integrity ; G protein-coupled receptor kinase interacting protein 2 (GIT2) ; MMR ; replicative stress ; senolytics ; spacer ; interactome ; ATR-Chk1 DDR pathway ; C9orf72 ; replication fork restart ; translesion DNA synthesis ; DNA damage ; mismatch repair ; DNA replication stress ; DNA helicase ; Polymerase kappa ; DNA fiber assay ; H1299 cells ; TLS ; APE2 ; ageing ; cell death ; chromosome ; TopBP1 ; barley ; clock proteins ; post-translational modification ; 8-oxoG ; S phase ; ataxia telangiectasia mutated (ATM) ; G protein-coupled receptor (GPCR) ; Polymerase eta ; cancer ; G protein-coupled receptor kinase (GRK) ; helicase ; genomic instability ; Parkinson’s disease ; nucleotide excision repair ; SupF ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 3
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: The aim of this Special Issue is to review, understand, and evaluate new and exciting opportunities from the field on regenerative medicine, biomaterials, and stem cell research for the bioengineering of human liver grafts that can be applied for transplantation and personalized treatment of end-stage liver disease.The development of culture conditions for long-term expansion of LGR5+ intestinal stem cells as crypt-villus structures demonstrated the feasibility of deriving complex, organ-like structures in vitro from primary adult tissues, including the liver. Moreover, human pluripotent stem cells (hPSCs) can be applied to generate functionally maturated liver and bile duct epithelial cells.In this Special Issue, we welcome reviews and original papers focussing on hepatic cell sources, including adult hepatic stem cells, organoids, fetal and induced pluripotent stem cells, and primary cells (i.e., hepatocytes, cholangiocytes, and endothelial cells) and how these cells can be applied in tissue engineering strategies to generate implantable and personalized liver grafts. Potential topics include, but are not limited to, the following: liver tissue engineering, liver regeneration, graft repair, liver stem cells and organoids, bio-scaffolds, and 3D printing.We invite you to contribute original research papers, as well as comprehensive reviews, aligned with these themes, to advance and improve the actual state-of-the-art in liver bioengineering and providing new opportunities for the imminent medical problem of organ and tissue shortage for transplantation.
    Keywords: QH301-705.5 ; Q1-390 ; n/a ; tissue engineering ; regenerative medicine ; liver tissue bioengineering ; additive manufacturing ; copper toxicosis ; hepatobiliary stent ; reconditioning ; medical device ; liver regeneration ; Wilson Disease ; stem cells ; preclinical large animal model ; liver ; stem cell transplantation ; liver bioreactors ; personalized medicine ; direct printing ; hydrogel ; 3D structuring ; oxygen persufflation ; end-stage liver diseases ; 3D printing ; liver transplantation ; bioengineered organ ; randomized controlled trail ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: Functional advanced biopolymers have received far less attention than renewable biomass (cellulose, rubber, etc.) used for energy production. Among the most advanced biopolymers known is chitosan. The term chitosan refers to a family of polysaccharides obtained by partial de-N-acetylation from chitin, one of the most abundant renewable resources in the biosphere. Chitosan has been firmly established as having unique material properties as well as biological activities. Either in its native form or as a chemical derivative, chitosan is amenable to being processed—typically under mild conditions—into soft materials such as hydrogels, colloidal nanoparticles, or nanofibers. Given its multiple biological properties, including biodegradability, antimicrobial effects, gene transfectability, and metal adsorption—to name but a few—chitosan is regarded as a widely versatile building block in various sectors (e.g., agriculture, food, cosmetics, pharmacy) and for various applications (medical devices, metal adsorption, catalysis, etc.). This Special Issue presents an updated account addressing some of the major applications, including also chemical and enzymatic modifications of oligos and polymers. A better understanding of the properties that underpin the use of chitin and chitosan in different fields is key for boosting their more extensive industrial utilization, as well as to aid regulatory agencies in establishing specifications, guidelines, and standards for the different types of products and applications.
    Keywords: QH301-705.5 ; QD415-436 ; Q1-390 ; chitosan ; cyclodextrin ; graft copolymer ; polyelectrolyte complex ; polymer carrier ; iron(III) hydroxide ; marine resources ; over-the counter-drug ; chitooligosaccharides ; papermaking ; methylene blue ; nanoparticles ; biosynthesis ; sorption competition ; self-masking nanosphere lithography ; Citrobacter ; wet-end ; skin care ; cicada ; chitosan derivative ; nanoparticle ; swelling ; bio-sorbent ; gene delivery ; metabolic pathway ; TEOS ; hydrogel ; dendrimer ; binary ; aerogels ; ionic liquids ; drug delivery systems ; sorption ; fruits ; FTIR ; hear care ; mechanism ; plant growth ; chitosan structure ; strontium ; click chemistry ; nanostructured biomaterial ; lead ; non-viral vectors ; thermal transition sol-gel ; single ; medical applications ; salt effects ; neodymium ; chitin derivative ; characterization ; easily recyclable ; bioflocculant ; deacetylation pattern ; drug delivery ; XRD ; zinc–chitosan complexes ; heterogeneous catalyst ; Boron ; controlled functionalization ; DSC ; eco-friendly formulations ; adsorption ; wastewater ; chitosan supported copper ; derivatization ; modelling ; mechanical properties ; chitin ; wet and dried states ; pDNA ; PEO/chitosan blend ; thermodynamic ; PCL ; craniofacial engineering ; desorption ; polymer ; biological activity ; mercury ; self-assembled ; oral care ; ionic cross-linking ; scaffolds ; cross-linking ; pesticides ; chitin deacetylases ; substrate specificity ; phase transition ; interpenetrating ; coating ; phosphate ; MTDSC ; siRNA ; structure ; defense responses ; organosilicon compound ; iron ; ionogels ; gelation mechanism ; carbohydrate esterases ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-01-31
    Description: We are currently experiencing a climate crisis that is associated with extreme weather events worldwide. Some of its most noticeable effects are increases in temperatures, droughts, and desertification. These effects are already making whole regions unsuitable for agriculture. Therefore, we urgently need global measures to mitigate the effects of climate breakdown as well as crop alternatives that are more stress-resilient. These crop alternatives can come from breeding new varieties of well-established crops, such as wheat and barley. They can also come from promoting underutilized crop species that are naturally tolerant to some stresses, such as quinoa. Either way, we need to gather more knowledge on how plants respond to stresses related to climate breakdown, such as heat, water-deficit, flooding high salinity, nitrogen, and heavy metal stress. This Special Issue provides a timely collection of recent advances in the understanding of plant responses to these stresses. This information will definitely be useful to the design of new strategies to prevent the loss of more cultivable land and to reclaim the land that has already been declared unsuitable.
    Keywords: SB1-1110 ; QH301-705.5 ; Q1-390 ; ZIP ; landraces ; orphan crop ; morphological characteristics ; De novo transcriptome ; lateral root ; abiotic stress ; heat stress ; transcriptome sequencing ; photosynthesis ; hyperaccumulation ; HSP70 ; photoprotection ; IREG ; photosystem I ; quinoa ; plant cell cultures ; water stress ; high temperatures ; tobacco BY-2 ; serpentine ; heat ; chaperons ; waterlogging ; water deficit ; photoinhibition ; selenium ; wheat ; Vigna vexillata ; mechanism ; grain protein content ; salinity ; nickel ; poaceae ; genome-wide association mapping ; nickel hyper-accumulation ; cell death ; mediterranean area ; ferroportin ; high salinity stress ; low nitrogen stress ; legume ; drought ; RNA-Seq ; histidine
    Language: English
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: Due to increasing global food needs as a result of population growth, the use of new food sources has gained interest in the last decade. However, the inclusion of new foods in our diet, as well as the increased interest of the population in consuming foods with better nutritional properties, has increased the need for adequate food analytical methods. This monographic issue presents innovative methods of chemical analysis of foods, as well as the nutritional and chemical characterization of foods whose consumption is expected to increase worldwide in the coming years.
    Keywords: QH301-705.5 ; Q1-390 ; TX341-641 ; blanching ; n/a ; acrylamide ; thickness ; seaweeds ; N-carbamylglutamate ; Chlorophyceae ; EPA+DHA ; hydrolysates ; Phaeophyceae ; carbohydrates ; scanning electron microscopy ; antioxidant ; scorpion (Buthus martensii Karsch) protein ; Gracilaria ; animal products ; milk ; prebiotic ; extraction ; functional properties ; refined commercial salmon oil ; HPLC-MS/MS ; total FA yield ; avocado oil ; n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) concentration ; DHA ; alcalase ; antioxidants compounds ; flavourzyme ; phenolic compounds ; UPLC-MSE ; oil extraction ; frying time ; response surface methodology ; fatty acid profile ; response surface methodology (RSM) ; Amazonian fruits ; water holding capacity ; phenolic acids ; amaranth protein ; temperature ; feeds ; multiple response optimization ; polysaccharides ; fatty acids ; Artemisia argyi leaves ; seaweed ; Rhodophyceae ; process variable maximization ; bioactive peptides ; vitamins ; EPA ; desirability function ; ultrasonic extraction ; bioactive compounds ; crisps ; deep eutectic solvents ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 7
    Publication Date: 2024-04-05
    Description: The Special Issue on high grade serous ovarian cancer (HGSOC) and the contribution of the tumor microenviroment (TME) consists of reviews contributed by leaders in the OC field. As HGSOC metastases have a highly complex TME, there is an urgent need to better understand the TME in general, its distinct components in particular, and the role of the TME in the context of disease recurrence and development of chemoresistance. The Special Issue incorporates the current understanding of the different parts of thd TME components, including the cancer cells themselves, the cells surrounding the cancer cells or stromal cells, and the cells of the immune system, which are attracted to the site of metastases. In addition to these cells of the TME, the role of various cellular factors made by the cells of the TME are also the subject of the reviews. In addition, reviews in this Special Issue cover the complex relationships between the molecular mechanisms of HGSOC progression, including genomic, epigenomic and transcriptomic changes and changes in the immune cell landscape, as these may provide attractive new molecular targets for HGSOC therapy.
    Keywords: QH301-705.5 ; RC254-282 ; ovarian cancer ; transcriptomic ; stroma ; immune cells ; epigenetics ; recurrence ; immunotherapies ; chemoresistance ; fibroblasts ; metastasis ; genomic ; tumor microenvironment ; cancer stem cells ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: This book will cover topics related to the preparation and use of heterogeneous catalytic systems for the transformation of renewable sources, as well as of materials deriving from agro-industrial wastes and by-products. At the same time, the ever-increasing importance of bioproducts, due to the acceptance and request of consumers, makes the upgrade of biomass into chemicals and materials not only an environmental issue, but also an economical advantage.
    Keywords: QH301-705.5 ; Q1-390 ; isoselenourea ; malignant ; chemotherapeutics ; epigenetics ; antitumor activity ; methylseleninic acid ; mTOR inhibitors ; tumor heterogeneity ; hypoxia ; ER stress ; melanoma ; EMT ; lipid peroxidation ; immune evasion ; hypoxia-inducible factors (HIFs) ; selenium-binding protein 1 ; glutathione ; DNA damage ; hSP56 ; apoptosis ; tocopherol ; anticancer ; viability ; SELENBP1 ; selenium ; clear-cell renal cell carcinoma microRNAs ; SBP1 ; entosis ; PD-L1 ; miRNA ; cancer stem cells ; cell plasticity ; disease ; clear cell renal cell carcinoma ; HIF ; head and neck cancer ; selenium species ; VEGF ; STAT3 ; hypoxia-inducible factor ; methylselenocysteine ; anticancer agent ; Se-containing nanoparticles ; DNA damage and repair ; radiation ; seleno-l-methionine ; cancer ; tumor microenvironment ; methylselenoesters ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 9
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: Pregnancy is a viewed as a window to future health. With the birth of the developmental origins of human adult disease hypothesis, research and clinical practice has turned its attention to the influence of maternal factors such as health and lifestyle surrounding pregnancy as a means to understand and prevent the inter-generational inheritance of chronic disease susceptibility. Outcomes during pregnancy have long-lasting impacts on both women on children. Moreover, nutrition early in life can influence growth and the establishment of lifelong eating habits and behaviors. This Special Issue on “Nutrition during Pregnancy and Lactation: Implications for Maternal and Infant Health” is intended to highlight new epidemiological, mechanistic and interventional studies that investigate maternal nutrition around the pregnancy period on maternal and infant outcomes. Submissions may include original research, narrative reviews, and systematic reviews and meta-analyses.
    Keywords: QH301-705.5 ; Q1-390 ; TX341-641 ; education ; 6?-sialyllactose ; milk composition ; growth chart ; overweight and obesity ; body composition ; pregnant women ; prenatal intervention ; thermal control ; slow digesting carbohydrates ; postpartum ; vitamin B12 ; micronutrients ; passive immunization ; antibodies ; physiological body-weight loss ; obesity ; proteolysis ; energy ; infant formula ; adolescents ; pregnancy ; gestational weight gain intervention ; randomized clinical trial ; food photography ; metabolic rate ; infancy ; micronutrient deficiency ; restraint ; folate ; nutrition ; lactation ; basal maintenance expenditure ; milk oligosaccharides ; maternal nutrition ; disinhibition ; weight retention ; DNA sequencing ; neuroplasticity ; generalized linear models ; metabolic flexibility ; non-alcoholic fatty liver disease ; prematurity ; full breastfeeding ; food cravings ; transcriptome ; maternal diet quality ; Healthy Eating Index ; human milk ; gestational weight gain ; energy expenditure ; lifestyle intervention ; RDA ; immunological properties ; mindful eating ; insulin-resistant pregnancy ; nutritional intervention ; DNA methylation ; neurobiology ; total sugars ; fetal growth ; overweight ; fetal development ; energy intake ; hippocampus ; race ; maternal obesity ; early programming ; uncontrolled and emotional eating ; breast milk ; health ; hepatic lipogenesis ; eating behavior ; physical activity ; Pregnancy ; meal replacements ; premature delivery ; sialic acid ; diet quality ; cognitive development ; iron ; growth ; breastfeeding ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: The role of biochar in improving soil fertility is increasingly being recognized and is leading to recommendations of biochar amendment of degraded soils. In addition, biochars offer a sustainable tool for managing organic wastes and to produce added-value products. The benefits of biochar use in agriculture and forestry can span enhanced plant productivity, an increase in soil C stocks, and a reduction of nutrient losses from soil and non-CO2 greenhouse gas emissions. Nevertheless, biochar composition and properties and, therefore, its performance as a soil amendment are highly dependent on the feedstock and pyrolysis conditions. In addition, due to its characteristics, such as high porosity, water retention, and adsorption capacity, there are other applications for biochar that still need to be properly tested. Thus, the 16 original articles contained in this book, which were selected and evaluated for this Special Issue, provide a comprehensive overview of the biological, chemicophysical, biochemical, and environmental aspects of the application of biochar as soil amendment. Specifically, they address the applicability of biochar for nursery growth, its effects on the productivity of various food crops under contrasting conditions, biochar capacity for pesticide retention, assessment of greenhouse gas emissions, and soil carbon dynamics. I would like to thank the contributors, reviewers, and the support of the Agronomy editorial staff, whose professionalism and dedication have made this issue possible.
    Keywords: QH301-705.5 ; Q1-390 ; S1-972 ; nutrient ; essential oil quality ; heavy metals ; mean residence time ; soil physics ; crop growth ; gas exchange attributes ; pyrolysis ; greenhouse experiment ; water retention ; qPCR ; Ultisols ; soil carbon dynamics ; composted solid digestate ; activated charcoal ; excessive compost application ; bacterial 16S rRNA gene ; yield attributes ; field experiment ; soil fertility ; nutrient cycling ; grapevine planting material ; germination ; nutrient concentration ; global warming ; soil chemical properties ; containerized production systems ; water stress ; sesame ; hydrochar ; soil health ; biochar-ash pellet ; gene expression ; vineyard by-products ; leaf chlorosis ; slow pool ; biochar ; archaeal 16S rRNA gene ; pore property ; soil organic matter ; hormone ; rice yields ; acidic undernourished soil ; biochar particle size ; fallen leaves ; soil physical properties ; pesticides ; soil amendments ; wheat ; paper mill sludge ; quality index ; biosolids ; dairy manure ; cropping ; Pelargonium graveolens ; solid digestate ; nitrogen ; thermochemical property ; biofertilizers ; jatropha ; 13C NMR ; fertilizer ; pyrochar ; incubation ; rice husk biochar ; arid region ; activated carbon ; aging ; soil chemistry ; desert soil ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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