ALBERT

Description: This paper explores the alternative roles hydrogen can play in the future European Union (EU) energy system, within the transition towards a carbon-neutral EU economy by 2050, following the latest policy developments after the COP21 agreement in Paris in 2015. Hydrogen could serve as an end-use fuel, a feedstock to produce carbon-neutral hydrocarbons and a carrier of chemical storage of electricity. We apply a model-based energy system analysis to assess the advantages and drawbacks of these three roles of hydrogen in a decarbonized energy system. To this end, the paper quantifies projections of the energy system using an enhanced version of the PRIMES energy system model, up to 2050, to explore the best elements of each role under various assumptions about deployment and maturity of hydrogen-related technologies. Hydrogen is an enabler of sectoral integration of supply and demand of energy, and hence an important pillar in the carbon-neutral energy system. The results show that the energy system has benefits both in terms of CO2 emission reductions and total system costs if hydrogen technology reaches high technology readiness levels and economies of scale. Reaching maturity requires a significant investment, which depends on the positive anticipation of market development. The choice of policy options facilitating visibility by investors is the focus of the modelling in this paper.

Description: The paper presents a newly developed economic-engineering model of the buildings sector and its implementation for all the European Union (EU) Member States (MS), designed to study in detail ambitious energy efficiency strategies and policies, in the context of deep decarbonisation in the long term. The model has been used to support the impact assessment study that accompanied the European Commission’s communication “A Clear Planet for All”, in November 2018. The model covers all EU countries with a fine resolution of building types, and represents agent decision-making in a complex and dynamic economic-engineering mathematical framework. Emphasis is given to behaviours driving the energy renovation of buildings and the ensuing choice of equipment for heating and cooling. The model represents several market and non-market policies that can influence energy decisions in buildings and promote deep energy renovation. Moreover, the paper presents key applications for supporting policies targeting ambitious reduction of energy consumption and carbon emissions in buildings across Europe. The results illustrate that the achievement of ambitious energy-efficiency targets in the long-term heavily depends on pursuing a fast and extensive renovation of existing buildings, at annual rates between 1.21% and 1.77% for the residential sector and between 0.92% to 1.35% for the services sector. In both cases, the renovation rates are far higher past trends. Strong policies aimed at removing non-market barriers are deemed necessary. Electrification constitutes a reasonable choice for deeply renovated buildings and, as a result, almost 50% of households chooses electric heating over gas heating in the long term. However, heat pumps need to exploit further their learning potential to be economical and implementable for the various climatic conditions in Europe. The results also show that the cost impacts are modest even if renovation and decarbonisation in buildings develop ambitiously in the EU. The reduced energy bills due to energy savings can almost offset the increasing capital expenditures. Fundraising difficulties and the cost of capital are, however, of concern.

Description: PATZ1 is a transcriptional factor downregulated in thyroid cancer whose re-expression in thyroid cancer cells leads to a partial reversion of the malignant phenotype, including the capacity to proliferate, migrate, and undergo epithelial-to-mesenchymal transition. We have recently shown that PATZ1 is specifically downregulated downstream of the Ras oncogenic signaling through miR-29b, and that restoration of PATZ1 in Ha-Ras transformed FRTL5 rat thyroid cells is able to inhibit their capacities to proliferate and migrate in vitro. Here, we analyzed the impact of PATZ1 expression on the in vivo tumorigenesis of these cells. Surprisingly, FRTL5-Ras-PATZ1 cells showed enhanced tumor initiation when engrafted in nude mice, even if their tumor growth rate was reduced compared to that of FRTL5-Ras control cells. To further investigate the cause of the enhanced tumor engraftment of FRTL5-Ras-PATZ1 cells, we analyzed the stem-like potential of these cells through their capacity to grow as thyrospheres. The results showed that restoration of PATZ1 expression in these cells increases stem cell markers’ expression and self-renewal ability of the thyrospheres while limiting their growth capacity. Therefore, we suggest that PATZ1 may play a role in enhancing the stem cell potential of thyroid cancer cells, but, at the same time, it impairs the proliferation of non-stem cells.

Description: The last increased volcanic activity of the Stromboli volcano, from 2016 to 2018, was characterized by increases in the number and frequency of crater explosions and by episodes of lava overflow. The volcanic activity was monitored utilizing CO2 soil fluxes acquired from the Stromboli summit area (STR02 station). To better understand the behavior of the shallow plumbing system of the Stromboli volcano in the period of 2016–2018, we utilized a large data set spanning from 2000 to 2018. The data in this last period confirm a long growing trend of CO2 summit degassing, already observed in the years since 2005 (reaching 23,000 g·m−2·d−1). Moreover, within this increasing trend, episodes of sudden and sharp increases in the degassing rate, up to 24.2 g·m−2·d−2 were recorded, which are correlated with the observed paroxysmal activity (increased summit explosions and overflow).

Description: Changes in national and global food demand are commonly explained by population growth, dietary shifts, and food waste. Although nutrition sciences demonstrate that biophysical characteristics determine food requirements in individuals, and medical and demographic studies provide evidence for large shifts in height, weight, and age structure worldwide, the aggregated effects for food demand are poorly understood. Here, a type–cohort–time stock model is applied to analyze the combined effect of biophysical and demographic changes in the adult population of 186 countries between 1975–2014. The average global adult in 2014 was 14% heavier, 1.3% taller, 6.2% older, and had a 6.1% higher energy demand than the average adult in 1975. Across countries, individuals’ weight gains ranged between 6–33%, and energy needs increased between 0.9–16%. Noteworthy, some of the highest and lowest increases coexist within Africa and Asia, signaling the disparities between the countries of these regions. Globally, food energy increased by 129% during the studied period. Population growth contributed with 116%; weight and height gains accounted for 15%; meanwhile, the aging phenomenon counteracted the rise in energy needs by −2%. This net additional 13% demand corresponded to the needs of 286 million adults. Since the effect of biodemographic changes are cumulative, we can expect the observed inertia to extend into the future. This work shows that considering the evolving individual biophysical characteristics jointly with sociodemographic changes can contribute to more robust global resource and food security assessments. Commonly used static and homogenous caloric demand values per capita might lead to misrepresentations of actual needs. What previous analyses could have estimated as increased food availability, sufficiency, or surplus waste might actually be energy sequestered by the mass of the human lot. Based on the discovered trends, feeding nine billion people in 2050 will require significantly more total calories than feeding the same people today.

Description: This article presents a description of the design, development, and implementation of web-based software and dedicated hardware which allows for the remote monitoring and control of a drip irrigation system. The hardware consists of in-field stations which are strategically distributed in the field and equipped with different sensors and communication devices; a weather station and drip irrigation system complete the setup. The web-based software makes it possible to remotely access and process the information gathered by all the stations and the irrigation controller. The proposed system was implemented in a young olive orchard, located in the province of San Juan, an arid region of Argentina. The system was installed and evaluated during the seasons 2014–2015 and 2015–2016. Four regulated irrigation strategies were proposed in the olive orchard to test its behavior. In this pilot experiment, the precision irrigation system was a useful tool for precisely managing the irrigation process, applying only the required amount of water (precise irrigation). Regulated deficit irrigation experiments, on the other hand, have demonstrated the sensitivity of olives to water restriction. The precision irrigation system made it possible to control soil moisture levels, avoiding water stress in the control treatment.

Description: This paper reviews protection schemes for meshed distribution networks. It gives emphasis to the increasing penetration of electric vehicles, their charging patterns, and to the increasing value of distributed generators, especially from renewables. It includes a preliminary analysis on system planning with electric vehicles that is studied probabilistically and a more detailed analysis of the expected changes introduced by these new loads. Finally, a real time hardware-in-the-loop review analysis for protection systems and the open source networks available for protection studies from several sources are also provided. This work could be useful as a collective review of the recent bibliography on protection for meshed networks, giving emphasis to electric vehicles and their real time simulation.

Description: The voltage distribution along the non-linear resistance of metal oxide surges is of great importance for their proper operation, since the non-uniform potential distribution results in higher thermal stresses of the varistor discs near the high voltage electrode, leading to a faster ageing of the discs at the top and, consequently, a downgrade in arrester effectiveness and reliability or even failures. The current work deals with the examination of the voltage distribution along the non-linear resistance of medium voltage metal oxide gapless surge arresters, using an appropriate computer tool, discussing configuration that improve the voltage distribution. Moreover, the impact of various factors on the voltage distribution is examined. The extracted results can contribute to the more efficient design of modern metal oxide gapless surge arresters, in an effort to ensure their reliable operation to protect the electrical equipment against lightning surges.

Description: Epidemiological and experimental studies emphasize the link between environmental chemicals exposure and thyroid cancer. However, this association is strongly debated and the mechanisms of action of environmental thyroid carcinogens still need to be identified. The analysis of in vitro transcriptomic data developed to investigate the effects of chlorpyrifos on immortalized thyrocytes highlighted the impaired expression of genes involved in endodermal carcinogenesis. This endodermal carcinogenic gene-network (ECGN, including Zfp36l2, Dmbt1, Ddit4), was validated in cellular and mouse models of thyroid carcinogenesis, characterized by the constitutive activation of the mitogen-activated protein kinase (MAPK) pathway and in immortalized thyrocytes exposed to tetrachlorodibenzo-p-dioxin (TCDD) and chlorpyrifos (CPF). The mRNA levels of Zfp36l2, Dmbt1 and Ddit4 were increased in models characterized by MAPK activation or following TCDD exposure, whereas they were inhibited by CPF exposure. Overall, the ECGN transcripts identify a novel gene-regulatory network associated with thyroid carcinogenesis promoted by genetic mutation or by environmental carcinogens. The latter have opposite effects on the modulation of the ECGN transcripts according to their mechanisms of action in promoting carcinogenesis. Therefore, the analyses of ECGN might be helpful in discriminating compounds that promote cellular survival associated or not to proliferation of thyrocytes.

Description: Climate change, associated with global warming, extreme weather events, and increasing incidence of weeds, pests and pathogens, is strongly influencing major cropping systems. In this challenging scenario, miscellaneous strategies are needed to expedite the rate of genetic gains with the purpose of developing novel varieties. Large plant breeding populations, efficient high-throughput technologies, big data management tools, and downstream biotechnology and molecular techniques are the pillars on which next generation breeding is based. In this review, we describe the toolbox the breeder has to face the challenges imposed by climate change, remark on the key role bioinformatics plays in the analysis and interpretation of big “omics” data, and acknowledge all the benefits that have been introduced into breeding strategies with the biotechnological and digital revolution.