Publication Date:
2018-08-04
Description:
In this paper, the formulation technology of gastric floating tablets of total alkaloids from Chelidonium majus (TAC) was optimized according to its behavior of floating and the release characteristics. Gastric floating tablets were prepared by direct compression with dry powder. The floating time and release performance were used as indexes to evaluate and optimize the formulation. Single factor tests and orthogonal tests were carried out to optimize formulation parameters which impacted properties of TAC gastric floating tablets. The optimal prescription processes were 20% of total alkaloid extracts from Chelidonium majus L. , 15 % HPMCK 15M , 15 % NaHCO 3 and 50 % microcrystalline cellulose PH-101 (MCC). The average release of the drug within 12h was 91.23%, the floating time was 3s, and the duration time was over 12h. In conclusion, the TAC gastric floating tablets prepared by the optimized orthogonal test showed a good floating performance wi...
Print ISSN:
1757-8981
Electronic ISSN:
1757-899X
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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