ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A simple, efficient, and stereospecific total synthesis of (±)-3α, 18-dihydroxy-17-noraphidicolan-16-one (2), by solvolytic rearrangement of the endo-bicyclo-[2.2.2]oct-5-en-2-yl methanesulfonate 16, is described. Since aphidicolin (1) has already been obtained from 2, the preparation of the latter formally constitutes a new total synthesis of 1.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19830660703
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