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  • 1
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    Expression and Significance of Insulin Receptor Substrate 1 in Human Hepatocellular Carcinoma (2020)
    Hindawi
    Details
    Publication Date: 2020-07-10
    Description: Background. Insulin receptor substrate 1 (IRS-1) is an important molecule of the insulin signal transduction pathway and has been associated with the occurrence and development of many tumors, including hepatocellular carcinoma (HCC). Our study was designed to determine the expression and significance of IRS-1 in human HCC. Methods. Two hundred and forty specimens were drawn from 140 patients, including 100 HCC tissues and 100 paracancerous (PC) tissues from 100 HCC patients, 20 liver cirrhosis (LC) tissues from 20 LC patients, and 20 chronic hepatitis (CH) tissues from 20 CH patients. Baseline and pathological characteristics were included, and the expression of IRS-1 was examined by immunohistochemical (IHC) staining. Binary logistic regression model calculation was used for multivariate analysis. Results. The total positive rates of IRS-1 expression were 41.0%, 17.0%, 15.0%, and 10.0% in HCC, PC, LC and CH tissues, respectively. IRS-1-positive signals were brown in color and located in the nucleus and cytoplasm. Compared with PC, LC, and CH tissues, a significantly increased expression was observed in human HCC tissues (P
    Print ISSN: 0278-0240
    Electronic ISSN: 1875-8630
    Topics: Biology , Chemistry and Pharmacology
    Published by Hindawi
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  • 2
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    An Improved Ant Colony Routing Algorithm for WSNs (2015)
    Hindawi
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    Publication Date: 2015-06-02
    Description: Ant colony algorithm is a classical routing algorithm. And it are used in a variety of application because it is economic and self-organized. However, the routing algorithm will expend huge amounts of energy at the beginning. In the paper, based on the idea of Dijkstra algorithm, the improved ant colony algorithm was proposed to balance the energy consumption of networks. Through simulation and comparison with basic ant colony algorithms, it is obvious that improved algorithm can effectively balance energy consumption and extend the lifetime of WSNs.
    Print ISSN: 1687-725X
    Electronic ISSN: 1687-7268
    Topics: Electrical Engineering, Measurement and Control Technology
    Published by Hindawi
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  • 3
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    Cholesterol-Lowering Potentials of Lactic Acid Bacteria Based on Bile-Salt Hydrolase Activity and Effect of Potent Strains on Cholesterol Metabolism In Vitro and In Vivo (2014)
    Hindawi
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    Publication Date: 2014-11-04
    Description: This study collected different probiotic isolates from animal and plant sources to evaluate the bile-salt hydrolase activity of probiotics in vitro. The deconjugation potential of bile acid was determined using high-performance liquid chromatography. HepG2 cells were cultured with probiotic strains with high BSH activity. The triglyceride (TG) and apolipoprotein B (apo B) secretion by HepG2 cells were evaluated. Our results show that the BSH activity and bile-acid deconjugation abilities of Pediococcus acidilactici NBHK002, Bifidobacterium adolescentis NBHK006, Lactobacillus rhamnosus NBHK007, and Lactobacillus acidophilus NBHK008 were higher than those of the other probiotic strains. The cholesterol concentration in cholesterol micelles was reduced within 24 h. NBHK007 reduced the TG secretion by 100% after 48 h of incubation. NBHK002, NBHK006, and NBHK007 could reduce apo B secretion by 33%, 38%, and 39%, respectively, after 24 h of incubation. The product PROBIO S-23 produced a greater decrease in the total concentration of cholesterol, low-density lipoprotein, TG, and thiobarbituric acid reactive substance in the serum or livers of hamsters with hypercholesterolemia compared with that of hamsters fed with a high-fat and high-cholesterol diet. These results show that the three probiotic strains of lactic acid bacteria are better candidates for reducing the risk of cardiovascular disease.
    Electronic ISSN: 1537-744X
    Topics: Natural Sciences in General
    Published by Hindawi
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  • 4
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    The Quadrotor Dynamic Modeling and Indoor Target Tracking Control Method (2014)
    Hindawi
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    Publication Date: 2014-03-21
    Description: A reliable nonlinear dynamic model of the quadrotor is presented. The nonlinear dynamic model includes actuator dynamic and aerodynamic effect. Since the rotors run near a constant hovering speed, the dynamic model is simplified at hovering operating point. Based on the simplified nonlinear dynamic model, the PID controllers with feedback linearization and feedforward control are proposed using the backstepping method. These controllers are used to control both the attitude and position of the quadrotor. A fully custom quadrotor is developed to verify the correctness of the dynamic model and control algorithms. The attitude of the quadrotor is measured by inertia measurement unit (IMU). The position of the quadrotor in a GPS-denied environment, especially indoor environment, is estimated from the downward camera and ultrasonic sensor measurements. The validity and effectiveness of the proposed dynamic model and control algorithms are demonstrated by experimental results. It is shown that the vehicle achieves robust vision-based hovering and moving target tracking control.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
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  • 5
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    A Nuclear Reactor Transient Methodology Based on Discrete Ordinates Method (2014)
    Hindawi
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    Publication Date: 2014-12-04
    Description: With the rapid development of nuclear power industry, simulating and analyzing the reactor transient are of great significance for the nuclear safety. The traditional diffusion theory is not suitable for small volume or strong absorption problem. In this paper, we have studied the application of discrete ordinates method in the numerical solution of space-time kinetics equation. The fully implicit time integration was applied and the precursor equations were solved by analytical method. In order to improve efficiency of the transport theory, we also adopted some advanced acceleration methods. Numerical results of the TWIGL benchmark problem presented demonstrate the accuracy and efficiency of this methodology.
    Print ISSN: 1687-6075
    Electronic ISSN: 1687-6083
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Hindawi
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  • 6
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    Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of Ferulic Acid Derivatives (2015)
    Hindawi
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    Publication Date: 2015-04-03
    Description: In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. The in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound 7f had potent antiplatelet aggregation activity with its IC50 27.6 μmol/L, and 7f can be regarded as a novel potent antiplatelet aggregation candidate.
    Print ISSN: 2090-9063
    Topics: Chemistry and Pharmacology
    Published by Hindawi
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  • 7
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    Equal Area Laws and Latent Heat for -Dimensional RN-AdS Black Hole (2014)
    Hindawi
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    Publication Date: 2014-11-20
    Description: We study the equal area laws of -dimensional RN-AdS black hole. We choose two kinds of phase diagrams, and . We employ the equal area laws to find an isobar which is the real two-phase coexistence line. Our calculation is much simpler to derive the critical value of the thermodynamic quantities. According to the thermodynamic quantities, we also study the latent heat of the black hole.
    Print ISSN: 1687-7357
    Electronic ISSN: 1687-7365
    Topics: Physics
    Published by Hindawi
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  • 8
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    Deep First Formal Concept Search (2014)
    Hindawi
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    Publication Date: 2014-09-01
    Description: The calculation of formal concepts is a very important part in the theory of formal concept analysis (FCA); however, within the framework of FCA, computing all formal concepts is the main challenge because of its exponential complexity and difficulty in visualizing the calculating process. With the basic idea of Depth First Search, this paper presents a visualization algorithm by the attribute topology of formal context. Limited by the constraints and calculation rules, all concepts are achieved by the visualization global formal concepts searching, based on the topology degenerated with the fixed start and end points, without repetition and omission. This method makes the calculation of formal concepts precise and easy to operate and reflects the integrity of the algorithm, which enables it to be suitable for visualization analysis.
    Electronic ISSN: 1537-744X
    Topics: Natural Sciences in General
    Published by Hindawi
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  • 9
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    Network-Coded Relaying in Multiuser Multicast D2D Network (2014)
    Hindawi
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    Publication Date: 2014-08-13
    Description: D2D communication trades short-range communication for achieving high communication rate and short communication latency. Relay aided D2D communication can further tackle the problem of intermediate obstacles blocking the communication. In this work, multidevice multicast communication via a layer of parallel relay nodes is considered. Two relaying strategies, respectively, called the conventional relaying (CR) and network-coded relaying (NCR), are proposed. The throughput of these two schemes is analytically derived and evaluated through numerical study. Theoretically, NCR shows advantage over CR in twofold: one is higher throughput and the other is requiring less relay nodes and, hence, consuming less aggregate power. Numerical studies verify the analysis and show that the throughput performance gap between the two schemes increases significantly, actually exponentially with the number of devices.
    Print ISSN: 1687-5869
    Electronic ISSN: 1687-5877
    Topics: Electrical Engineering, Measurement and Control Technology
    Published by Hindawi
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  • 10
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    Multivariate Analysis of Confined Groundwater Hydrochemistry of a Long-Exploited Sedimentary Basin in Northwest China (2016)
    Hindawi
    Details
    Publication Date: 2016-03-24
    Description: A series of environmental and geological problems have been caused by overexploitation of confined aquifers (i.e., deep groundwater) in the Yinchuan region, northwest China. Accordingly, the characteristics of confined water were analyzed and collected from 33 sampling wells in spring of 2011, to determine the factors that influenced the composition and evolution of confined water, using principal component analysis (PCA), correlation analysis, groundwater evolution, and mineral dissolution/precipitation analysis. PCA showed that the hydrochemistry of confined water is controlled mainly by the dissolution of minerals, mixing between the confined aquifer and polluted phreatic water, and effects of ion exchange in the study area. The following management actions recommended were essential, in order to enable the sustainable exploitation of confined water: () gradually decreasing the amount of groundwater pumped from confined aquifer in the central part of the depression cone, () upgrading the quality of phreatic water, and () increasing artificial recharge of the groundwater system by flood waters in the Helan leaning pluvial plain.
    Print ISSN: 2090-9063
    Topics: Chemistry and Pharmacology
    Published by Hindawi
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