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  • 1
    Publication Date: 2012-06-21
    Description: Autophagy provides a mechanism for the turnover of cellular organelles and proteins through a lysosome-dependent degradation pathway. During starvation, autophagy exerts a homeostatic function that promotes cell survival by recycling metabolic precursors. Additionally, autophagy can interact with other vital processes such as programmed cell death, inflammation, and adaptive immune mechanisms, and thereby potentially influence disease pathogenesis. Macrophages deficient in autophagic proteins display enhanced caspase-1-dependent proinflammatory cytokine production and the activation of the inflammasome. Autophagy provides a functional role in infectious diseases and sepsis by promoting intracellular bacterial clearance. Mutations in autophagy-related genes, leading to loss of autophagic function, have been implicated in the pathogenesis of Crohn's disease. Furthermore, autophagy-dependent mechanisms have been proposed in the pathogenesis of several pulmonary diseases that involve inflammation, including cystic fibrosis and pulmonary hypertension. Strategies aimed at modulating autophagy may lead to therapeutic interventions for diseases associated with inflammation.
    Print ISSN: 1687-8876
    Electronic ISSN: 1687-8884
    Topics: Biology
    Published by Hindawi
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  • 2
    Publication Date: 2015-05-09
    Description: We investigate an electron flux dropout during a weak storm on November 7–8, 2008, with Dst minimum value being −37 nT. During this period, two clear dropouts were observed on GOES-11 〉 2MeV electrons. We also find a simultaneous dropout in the sub-relativistic electrons recorded by THEMIS probes in the outer radiation belt. Using the Radiation Belt Environment (RBE) model, we try to reproduce the observed dropout features in both relativistic and sub-relativistic electrons. We found that there are local time dependences in the dropout for both observation and simulation in sub-relativistic electrons; (1) particle loss begins from nightside and propagates into dayside, and (2) resupply starts from near dawn MLT and propagates into the dayside following electron drift direction. That resupply of the particles might be caused by substorm injections due to enhanced convection. We found a significant precipitation in hundreds keV electrons during the dropout. We observe electromagnetic ion cyclotron (EMIC) and chorus waves both on the ground and in space. We find the drift shells are opened near the beginning of the first dropout. The dropout in MeV electrons at GEO might therefore be initiated due to the magnetopause shadowing and the followed dropout in hundreds keV electrons might be the result of the combination of magnetopause shadowing and precipitation loss into the earth's atmosphere.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 3
    Publication Date: 2019
    Description: Abstract Non‐Darcy flow (also known as high‐velocity flow, inertial flow, etc.) often occurs in the near‐well region of a reservoir during injection or production. This flow needs to be characterized and its origins fully understood, as it is a critical factor in reducing well productivity. The Forchheimer equation, which describes fluid flow considering an inertial effect, can be adopted to analyze non‐Darcy flow. In particular, the non‐Darcy coefficient in the equation represents inertial resistance in a porous medium and is an empirical value that depends on the pore geometry and fluid properties. This study, as part of research on geological CO2 storage, reports non‐Darcy flow tests with a high flow rate and examines the non‐Darcy coefficient by using supercritical CO2 and various sandstones. The dependence of the coefficient on the properties of the supercritical CO2 was also assessed in a series of non‐Darcy tests under different pore pressures. The coefficient varied with the properties of the supercritical CO2 and sandstone. As the permeability of sandstone increased, the non‐Darcy coefficient decreased nonlinearly and converged to a value. The results also indicate that the coefficient is reduced with a decreasing ratio of density to viscosity for the supercritical CO2. An equation predicting the coefficient was derived, having the advantage that both the hydraulic properties of rock and the fluid properties can be considered simultaneously in a dimensionally correct analysis.
    Print ISSN: 2169-9313
    Electronic ISSN: 2169-9356
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 4
    Publication Date: 1988-01-01
    Print ISSN: 0002-1962
    Electronic ISSN: 1435-0645
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Wiley
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