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  • Wiley  (3)
  • Institute of Physics (IOP)  (2)
  • Hindawi  (1)
  • 1
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    Autophagy in Inflammatory Diseases (2012)
    Hindawi
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    Publikationsdatum: 2012-06-21
    Beschreibung: Autophagy provides a mechanism for the turnover of cellular organelles and proteins through a lysosome-dependent degradation pathway. During starvation, autophagy exerts a homeostatic function that promotes cell survival by recycling metabolic precursors. Additionally, autophagy can interact with other vital processes such as programmed cell death, inflammation, and adaptive immune mechanisms, and thereby potentially influence disease pathogenesis. Macrophages deficient in autophagic proteins display enhanced caspase-1-dependent proinflammatory cytokine production and the activation of the inflammasome. Autophagy provides a functional role in infectious diseases and sepsis by promoting intracellular bacterial clearance. Mutations in autophagy-related genes, leading to loss of autophagic function, have been implicated in the pathogenesis of Crohn's disease. Furthermore, autophagy-dependent mechanisms have been proposed in the pathogenesis of several pulmonary diseases that involve inflammation, including cystic fibrosis and pulmonary hypertension. Strategies aimed at modulating autophagy may lead to therapeutic interventions for diseases associated with inflammation.
    Print ISSN: 1687-8876
    Digitale ISSN: 1687-8884
    Thema: Biologie
    Publiziert von Hindawi
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Comprehensive analysis of the flux dropout during 7–8 November 2008 storm using multi-satellites observations and RBE model (2015)
    Wiley
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    Publikationsdatum: 2015-05-09
    Beschreibung: We investigate an electron flux dropout during a weak storm on November 7–8, 2008, with Dst minimum value being −37 nT. During this period, two clear dropouts were observed on GOES-11 〉 2MeV electrons. We also find a simultaneous dropout in the sub-relativistic electrons recorded by THEMIS probes in the outer radiation belt. Using the Radiation Belt Environment (RBE) model, we try to reproduce the observed dropout features in both relativistic and sub-relativistic electrons. We found that there are local time dependences in the dropout for both observation and simulation in sub-relativistic electrons; (1) particle loss begins from nightside and propagates into dayside, and (2) resupply starts from near dawn MLT and propagates into the dayside following electron drift direction. That resupply of the particles might be caused by substorm injections due to enhanced convection. We found a significant precipitation in hundreds keV electrons during the dropout. We observe electromagnetic ion cyclotron (EMIC) and chorus waves both on the ground and in space. We find the drift shells are opened near the beginning of the first dropout. The dropout in MeV electrons at GEO might therefore be initiated due to the magnetopause shadowing and the followed dropout in hundreds keV electrons might be the result of the combination of magnetopause shadowing and precipitation loss into the earth's atmosphere.
    Print ISSN: 0148-0227
    Thema: Geologie und Paläontologie , Physik
    Publiziert von Wiley im Namen von American Geophysical Union (AGU).
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Effect of PAHM (Poly-acrylonitrile Hollow Microsphere) addition on the Lightweight and Firing Behavior of Whiteware (2011)
    Institute of Physics (IOP)
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    Publikationsdatum: 2011-09-17
    Beschreibung: The pore generation technology using PAHM (Poly-acrylonitrile Hollow Microsphere) was studied in order to reduce the weights of tableware. In this study, we verify the property of modified slurry and plasticity of green body by adding PAHM. The modified slurry was prepared by adding 25~55vol% of PAHM to the slurry for whiteware. The viscosity of slurry was controlled to be low value (25~45vol%). However, the viscosity of modified slurry increased and the plasticity of modified green body decreased inside the 45~55vol% range. The formed specimen by slip casting was fired at 1225 °C, 1240°C. As the amount of PAHM content increased, the weight decreased and the addition of 45vol/% of PAHM resulted in a weight drop of 39%. However, when the PAHM content increased, the strength decreases over 50%. This is caused by the presence of a large volume of surface defects (pores) and defects from the agglomeration of PAHM.
    Print ISSN: 1757-8981
    Digitale ISSN: 1757-899X
    Thema: Maschinenbau
    Publiziert von Institute of Physics (IOP)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Estimation of the Non‐Darcy Coefficient Using Supercritical CO2 and Various Sandstones (2019)
    Wiley
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    Publikationsdatum: 2019
    Beschreibung: Abstract Non‐Darcy flow (also known as high‐velocity flow, inertial flow, etc.) often occurs in the near‐well region of a reservoir during injection or production. This flow needs to be characterized and its origins fully understood, as it is a critical factor in reducing well productivity. The Forchheimer equation, which describes fluid flow considering an inertial effect, can be adopted to analyze non‐Darcy flow. In particular, the non‐Darcy coefficient in the equation represents inertial resistance in a porous medium and is an empirical value that depends on the pore geometry and fluid properties. This study, as part of research on geological CO2 storage, reports non‐Darcy flow tests with a high flow rate and examines the non‐Darcy coefficient by using supercritical CO2 and various sandstones. The dependence of the coefficient on the properties of the supercritical CO2 was also assessed in a series of non‐Darcy tests under different pore pressures. The coefficient varied with the properties of the supercritical CO2 and sandstone. As the permeability of sandstone increased, the non‐Darcy coefficient decreased nonlinearly and converged to a value. The results also indicate that the coefficient is reduced with a decreasing ratio of density to viscosity for the supercritical CO2. An equation predicting the coefficient was derived, having the advantage that both the hydraulic properties of rock and the fluid properties can be considered simultaneously in a dimensionally correct analysis.
    Print ISSN: 2169-9313
    Digitale ISSN: 2169-9356
    Thema: Geologie und Paläontologie , Physik
    Publiziert von Wiley im Namen von American Geophysical Union (AGU).
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    The Environmental Load Characteristic Analysis of LCA-based IPC Girder Bridge (2018)
    Institute of Physics (IOP)
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    Publikationsdatum: 2018-06-22
    Beschreibung: The carbon emission amount of the Republic of Korea ranks 8 th in the world including China and the US and accordingly, the government announced its emission reduction plan by 37% compared to BAU (8.51 million tons) by 2030. As a result of the emission trading scheme that has been implemented since 2015, efforts are being made to reduce environmental load. Accordingly, this study analyzed the material-specific environmental load distribution and environmental impact category for 60 IPC girder bridges of national road constructions in Korea by utilizing the life cycle assessment (LCA) method. The analysis result was found to be in the order of ready-mixed concrete (RMC) (64.00%), rebar (9.1%), timber (7.8%) and plywood (5.6%). As for environmental impact category-specific result, it was found to be in the order of global warming (50.60%), abiotic resource depletion (32.20%), photochemical oxidant creation (POC) (10.10%) and human toxicity (HT) (7.10%), thereby considere...
    Print ISSN: 1755-1307
    Digitale ISSN: 1755-1315
    Thema: Geographie , Geologie und Paläontologie , Physik
    Publiziert von Institute of Physics (IOP)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Effect of Temperature, Moisture, and Soil Texture on DCPA Degradation (1988)
    Wiley
    Details
    Publikationsdatum: 1988-01-01
    Print ISSN: 0002-1962
    Digitale ISSN: 1435-0645
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Publiziert von Wiley
    Standort Signatur Erwartet Verfügbarkeit
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