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  • Books  (19)
  • Q1-390  (18)
  • QH301-705.5  (11)
  • MDPI - Multidisciplinary Digital Publishing Institute  (19)
  • Hanover, NH : U.S. Army Cold Regions Research and Engineering Laboratory
  • 1
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    Major Histocompatibility Complex (MHC) in Health and Disease (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-05
    Description: The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.
    Keywords: QH301-705.5 ; Q1-390 ; HCP5 ; n/a ; camels ; MHC ; STK19 ; major histocompatibility complex ; human papillomavirus (HPV) ; T-cell receptor ; T1DGC ; bottleneck ; micro-mini-pigs ; life history ; computational analysis ; hepatocellular carcinoma ; phase ; Bactrian camel ; NSDK ; melanoma ; antigen ; autoimmune disease ; RD ; selection ; disease resistance ; autoimmunity ; ancestral haplotype ; Ski complex ; DXO ; high-throughput sequencing ; conservation genetics ; SVA ; lncRNA ; ankylosing spondylitis ; MHC genes ; viral peptides ; competing endogenous RNA (ceRNA) ; astrogliosis ; birds ; long-fragment super haplotype ; SNP ; RLR ; HLA polymorphism ; 5??3? RNA decay ; expression ; 3??5? mRNA turnover ; orthology ; long-read sequencing ; disease association ; dromedary ; polyomavirus ; MHC-II-associated sperm-egg recognition ; experimental medicine ; single nucleotide polymorphism (SNP) ; fish ; SKIV2L ; production trait ; molecular dynamics simulation ; Macaca fascicularis ; human endogenous retrovirus (HERV) ; concerted evolution ; polymorphism ; Old World camels ; MHC polymorphism ; protocol ; nonclassical ; gene duplication ; microglial reaction ; human leukocyte antigen-E ; SKI2W ; quantitative trait loci (QTL) studies ; antiviral immunity ; human immunodeficiency virus (HIV) ; founder effect ; giant panda ; domain movements ; BK virus ; promoter-proximal transcriptional pause ; type 1 diabetes (T1D) ; RP1 ; miR1236 ; KIR ; synaptic covering ; swine leukocyte antigen ; cynomolgus macaque ; HLA ; kidney transplantation ; ?2m knockout mice ; DOM3Z ; interferon ? ; ethnic populations in China ; ecology ; KIR–HLA pairs ; exosomes ; major histocompatibility complex (MHC) ; MHC-I-based mother-fetus recognition ; RNA quality control ; autoimmune diseases ; NELF-E ; haplotype ; genetic drift ; evolution ; nonhuman primate models ; HLA-B27 ; PNS/CNS interface ; risk genes ; pedigree ; MHC-I- and MHC-II-dependent inter-individual recognition ; regulation ; crested ibis ; reproductive performance ; nephropathy ; cancer ; nuclear kinase ; trichohepatoenteric syndrome ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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    Advancing Earth Surface Representation via Enhanced Use of Earth Observations in Monitoring and Forecasting Applications (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-20
    Description: The representation of the Earth's surface in global monitoring and forecasting applications is moving towards capturing more of the relevant processes, while maintaining elevated computational efficiency and therefore a moderate complexity. These schemes are developed and continuously improved thanks to well instrumented field-sites that can observe coupled processes occurring at the surface–atmosphere interface (e.g., forest, grassland, cropland areas and diverse climate zones). Approaching global kilometer-scale resolutions, in situ observations alone cannot fulfil the modelling needs, and the use of satellite observation becomes essential to guide modelling innovation and to calibrate and validate new parameterization schemes that can support data assimilation applications. In this book, we review some of the recent contributions, highlighting how satellite data are used to inform Earth surface model development (vegetation state and seasonality, soil moisture conditions, surface temperature and turbulent fluxes, land-use change detection, agricultural indicators and irrigation) when moving towards global km-scale resolutions.
    Keywords: Q1-390 ; direct and inverse methods ; absorption coefficient ; emissivity ; land-surface model ; n/a ; variational retrieval ; temporal autocorrelation ; Bayesian bias correction ; hyperspectral ; infrared ; BRDF ; satellite rainfall ; MCD43C1 ; penetration depth ; RTTOV ; earth-observations ; earth system modelling ; representative depth ; land ; Changjiang (Yangtze) estuary ; CDOM ; soil moisture ; surface ; Maqu network ; surface soil moisture ; MODIS ; soil effective temperature ; GOCI ; microwave remote sensing ; rain gauge ; QAA inversion ; broadband emissivity ; radiation ; surface parameters ; satellite data ; East Africa ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
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    Quantum Foundations. 90 Years of Uncertainty (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-01-31
    Description: The name of Joseph Fourier is also inseparable from the study of the mathematics of heat. Modern research on heat equations explores the extension of the classical diffusion equation on Riemannian, sub-Riemannian manifolds, and Lie groups. In parallel, in geometric mechanics, Jean-Marie Souriau interpreted the temperature vector of Planck as a space-time vector, obtaining, in this way, a phenomenological model of continuous media, which presents some interesting properties.
    Keywords: Q1-390 ; QC1-999 ; entanglement indicators ; generalized uncertainty principle ; Tsallis entropy ; linear entropy ; quantum-classical relationship ; Wigner–Yanase–Dyson skew information ; deep learning ; spinors in quantum and classical physics ; quantum mechanics ; entropy ; original Bell inequality ; Bohmian dynamics ; qudit states ; square integrable ; uncertainty relation ; quantum bound ; uncertainty relations ; foundations of quantum mechanics ; Born probability rule ; Rényi entropy ; energy quantization ; quantum foundations ; Born rule ; measure of classicality ; minimal observable length ; quantum information ; Kochen–Specker theorem ; neuromorphic computing ; bell inequalities ; successive measurements ; Gleason theorem ; continuous variables ; quantum memory ; perfect correlation/anticorrelation ; quantum trajectory ; quantum computing ; high performance computing ; Quantum Hamilton-Jacobi Formalism ; quantum uncertainty
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    DNA Replication Stress (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2024-04-05
    Description: This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.
    Keywords: QH301-705.5 ; Q1-390 ; Werner Syndrome ; n/a ; A549 cells ; epigenetic ; neurodegeneration ; Genome integrity ; adaptation ; cellular senescence ; genome instability ; Werner Syndrome Protein ; lipofuscin ; cell cycle checkpoints ; exonuclease 1 ; template-switching ; energy metabolism ; mutation frequency ; DNA replication ; fork regression ; motor neuron disease ; Microsatellites ; Alzheimer’s disease ; chromatin remodeler ; repair of DNA damage ; AP site analogue ; mutagens ; replication timing ; Thermococcus eurythermalis ; nucleolar stress ; gene expression ; mutations spectra ; origin firing ; Fanconi Anemia ; superfamily 2 ATPase ; DNA translocation ; DNA repair ; SSB signaling ; homologous recombination ; common fragile sites ; 8-chloro-adenosine ; replication ; genome stability ; mutagenicity ; fork reversal ; multiple sclerosis ; non-B DNA ; protein stability ; heterogeneity ; ubiquitin ; SenTraGorTM (GL13) ; replication restart ; EdU ; ?-arrestin ; NER ; aging ; SSB end resection ; oxidative stress ; ATR ; dormant origins ; R loops ; DNA damage response ; Difficult-to-Replicate Sequences ; DNA double-strand repair ; endonuclease IV ; ALS ; double strand break repair ; premature aging ; replication stress ; EXO1 ; POL? ; translesion synthesis ; strand displacements ; G2-arrest ; DNA replication pattern ; SSB repair ; genome integrity ; G protein-coupled receptor kinase interacting protein 2 (GIT2) ; MMR ; replicative stress ; senolytics ; spacer ; interactome ; ATR-Chk1 DDR pathway ; C9orf72 ; replication fork restart ; translesion DNA synthesis ; DNA damage ; mismatch repair ; DNA replication stress ; DNA helicase ; Polymerase kappa ; DNA fiber assay ; H1299 cells ; TLS ; APE2 ; ageing ; cell death ; chromosome ; TopBP1 ; barley ; clock proteins ; post-translational modification ; 8-oxoG ; S phase ; ataxia telangiectasia mutated (ATM) ; G protein-coupled receptor (GPCR) ; Polymerase eta ; cancer ; G protein-coupled receptor kinase (GRK) ; helicase ; genomic instability ; Parkinson’s disease ; nucleotide excision repair ; SupF ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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    Causes and Consequences of Species Diversity in Forest Ecosystems (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-09
    Description: What are the causes and consequences of species diversity in forested ecosystems, and how is this species diversity being affected by rapid environmental and climatic change, movement of invertebrate and vertebrate herbivores into new biogeographic regions, and expanding human populations and associated shifts in land-use patterns? In this book, we explore these questions for assemblages of forest trees, shrubs, and understory herbs at spatial scales ranging from small plots to large forest dynamics plots, at temporal scales ranging from seasons to centuries, in both temperate and tropical regions, and across rural-to-urban gradients in land use.
    Keywords: G1-922 ; Q1-390 ; gamma diversity ; tree species ; Climatic change ; individual species-area relationship ; woody species ; TILD ; trees ; Pseudotsuga menziesii ; windthrow ; precipitation ; species conservation ; spatial analysis ; codispersion analysis ; variation partitioning ; herbaceous perennial species ; northern hardwood forests ; climate change ; stand development ; potential habitats ; Smithsonian ForestGEO ; tree regeneration ; forest conversion ; Biodiversity Exploratories ; trunk breakage ; topography ; questionnaire survey ; mid-domain effect ; assemblage lineage diversity ; Salicaceae ; salvaging ; temperate forests ; Shannon diversity ; USDA Forest Service ; tree species diversity ; Bray-Curtis ; species-area relationship ; Ericaceae ; legacies ; Picea abies ; herbaceous layer ; spatial patterns ; mountains ; United States ; wind damage ; abundance ; Hubbard Brook ; elevational shifts ; uprooting ; species diversity ; evolutionary diversity ; Pinus sylvestris ; natural disturbance-based silviculture ; Vietnam ; diversity ; Maxent ; human footprint ; productivity ; China ; microarthropod ; phylogenetic diversity ; temperature ; household respondents ; succession ; biodiversity ; tornado ; salvage logging ; excess nitrogen ; climate ; forest management ; understory plant communities ; Simpson diversity ; species richness ; landscape scale ; structural complexity ; tropical evergreen mixed forest ; seasonal variations ; disturbance severity ; competition and facilitation ; canopy structure ; Fagus sylvatica ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography
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    Large Grid-Connected Wind Turbines (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2023-12-20
    Description: This book covers the technological progress and developments of a large-scale wind energy conversion system along with its future trends, with each chapter constituting a contribution by a different leader in the wind energy arena. Recent developments in wind energy conversion systems, system optimization, stability augmentation, power smoothing, and many other fascinating topics are included in this book. Chapters are supported through modeling, control, and simulation analysis. This book contains both technical and review articles.
    Keywords: Q1-390 ; QC1-999 ; doubly-fed induction generator ; fault current limiters ; power system ; power smoothing ; fault characteristics ; prediction intervals ; wind forecast ; PI controller ; transmission line ; wake effect ; real fault cases ; reliability of electricity supplies ; load frequency control ; optimization ; reserve power ; battery energy storage system ; wind turbine allocation ; primary frequency control ; low voltage ride through (LVRT) ; de-loading ; fault ride-through ; fault diagnosis and isolation ; fractional order proportional-integral-differential controller ; multi-objective artificial bee colony algorithm ; Fault Ride Through (FRT) ; distance protection ; droop curve ; Distribution Static VAr Compensator(D-SVC) ; Distributed-Flexible AC Transmission system (D-FACTS) ; rotor inertia ; power wind turbine ; LPV observer ; doubly fed induction generator (DFIG) ; squirrel cage induction generator (SCIG) ; wind farm ; optimal control ; fuzzy logic controller (FLC) ; wind power forecasting ; wavelet neural network ; DFIG-based wind farm ; permanent magnet synchronous generator ; automatic generation control ; series dynamic braking resistor ; hardware-in-the-loop ; superconductor ; Distribution Static Synchronous Compensator (D-STATCOM) ; control wind turbine ; kinetic energy storage ; multiple sensor faults ; large-scale wind farm ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
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  • 7
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    Bioengineering Liver Transplantation (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2024-04-05
    Description: The aim of this Special Issue is to review, understand, and evaluate new and exciting opportunities from the field on regenerative medicine, biomaterials, and stem cell research for the bioengineering of human liver grafts that can be applied for transplantation and personalized treatment of end-stage liver disease.The development of culture conditions for long-term expansion of LGR5+ intestinal stem cells as crypt-villus structures demonstrated the feasibility of deriving complex, organ-like structures in vitro from primary adult tissues, including the liver. Moreover, human pluripotent stem cells (hPSCs) can be applied to generate functionally maturated liver and bile duct epithelial cells.In this Special Issue, we welcome reviews and original papers focussing on hepatic cell sources, including adult hepatic stem cells, organoids, fetal and induced pluripotent stem cells, and primary cells (i.e., hepatocytes, cholangiocytes, and endothelial cells) and how these cells can be applied in tissue engineering strategies to generate implantable and personalized liver grafts. Potential topics include, but are not limited to, the following: liver tissue engineering, liver regeneration, graft repair, liver stem cells and organoids, bio-scaffolds, and 3D printing.We invite you to contribute original research papers, as well as comprehensive reviews, aligned with these themes, to advance and improve the actual state-of-the-art in liver bioengineering and providing new opportunities for the imminent medical problem of organ and tissue shortage for transplantation.
    Keywords: QH301-705.5 ; Q1-390 ; n/a ; tissue engineering ; regenerative medicine ; liver tissue bioengineering ; additive manufacturing ; copper toxicosis ; hepatobiliary stent ; reconditioning ; medical device ; liver regeneration ; Wilson Disease ; stem cells ; preclinical large animal model ; liver ; stem cell transplantation ; liver bioreactors ; personalized medicine ; direct printing ; hydrogel ; 3D structuring ; oxygen persufflation ; end-stage liver diseases ; 3D printing ; liver transplantation ; bioengineered organ ; randomized controlled trail ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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    Advances in Chitin/Chitosan Characterization and Applications (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2024-04-05
    Description: Functional advanced biopolymers have received far less attention than renewable biomass (cellulose, rubber, etc.) used for energy production. Among the most advanced biopolymers known is chitosan. The term chitosan refers to a family of polysaccharides obtained by partial de-N-acetylation from chitin, one of the most abundant renewable resources in the biosphere. Chitosan has been firmly established as having unique material properties as well as biological activities. Either in its native form or as a chemical derivative, chitosan is amenable to being processed—typically under mild conditions—into soft materials such as hydrogels, colloidal nanoparticles, or nanofibers. Given its multiple biological properties, including biodegradability, antimicrobial effects, gene transfectability, and metal adsorption—to name but a few—chitosan is regarded as a widely versatile building block in various sectors (e.g., agriculture, food, cosmetics, pharmacy) and for various applications (medical devices, metal adsorption, catalysis, etc.). This Special Issue presents an updated account addressing some of the major applications, including also chemical and enzymatic modifications of oligos and polymers. A better understanding of the properties that underpin the use of chitin and chitosan in different fields is key for boosting their more extensive industrial utilization, as well as to aid regulatory agencies in establishing specifications, guidelines, and standards for the different types of products and applications.
    Keywords: QH301-705.5 ; QD415-436 ; Q1-390 ; chitosan ; cyclodextrin ; graft copolymer ; polyelectrolyte complex ; polymer carrier ; iron(III) hydroxide ; marine resources ; over-the counter-drug ; chitooligosaccharides ; papermaking ; methylene blue ; nanoparticles ; biosynthesis ; sorption competition ; self-masking nanosphere lithography ; Citrobacter ; wet-end ; skin care ; cicada ; chitosan derivative ; nanoparticle ; swelling ; bio-sorbent ; gene delivery ; metabolic pathway ; TEOS ; hydrogel ; dendrimer ; binary ; aerogels ; ionic liquids ; drug delivery systems ; sorption ; fruits ; FTIR ; hear care ; mechanism ; plant growth ; chitosan structure ; strontium ; click chemistry ; nanostructured biomaterial ; lead ; non-viral vectors ; thermal transition sol-gel ; single ; medical applications ; salt effects ; neodymium ; chitin derivative ; characterization ; easily recyclable ; bioflocculant ; deacetylation pattern ; drug delivery ; XRD ; zinc–chitosan complexes ; heterogeneous catalyst ; Boron ; controlled functionalization ; DSC ; eco-friendly formulations ; adsorption ; wastewater ; chitosan supported copper ; derivatization ; modelling ; mechanical properties ; chitin ; wet and dried states ; pDNA ; PEO/chitosan blend ; thermodynamic ; PCL ; craniofacial engineering ; desorption ; polymer ; biological activity ; mercury ; self-assembled ; oral care ; ionic cross-linking ; scaffolds ; cross-linking ; pesticides ; chitin deacetylases ; substrate specificity ; phase transition ; interpenetrating ; coating ; phosphate ; MTDSC ; siRNA ; structure ; defense responses ; organosilicon compound ; iron ; ionogels ; gelation mechanism ; carbohydrate esterases ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 9
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    Molecular Mechanisms and Genetics of Plant Resistance to Abiotic Stress (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2022-01-31
    Description: We are currently experiencing a climate crisis that is associated with extreme weather events worldwide. Some of its most noticeable effects are increases in temperatures, droughts, and desertification. These effects are already making whole regions unsuitable for agriculture. Therefore, we urgently need global measures to mitigate the effects of climate breakdown as well as crop alternatives that are more stress-resilient. These crop alternatives can come from breeding new varieties of well-established crops, such as wheat and barley. They can also come from promoting underutilized crop species that are naturally tolerant to some stresses, such as quinoa. Either way, we need to gather more knowledge on how plants respond to stresses related to climate breakdown, such as heat, water-deficit, flooding high salinity, nitrogen, and heavy metal stress. This Special Issue provides a timely collection of recent advances in the understanding of plant responses to these stresses. This information will definitely be useful to the design of new strategies to prevent the loss of more cultivable land and to reclaim the land that has already been declared unsuitable.
    Keywords: SB1-1110 ; QH301-705.5 ; Q1-390 ; ZIP ; landraces ; orphan crop ; morphological characteristics ; De novo transcriptome ; lateral root ; abiotic stress ; heat stress ; transcriptome sequencing ; photosynthesis ; hyperaccumulation ; HSP70 ; photoprotection ; IREG ; photosystem I ; quinoa ; plant cell cultures ; water stress ; high temperatures ; tobacco BY-2 ; serpentine ; heat ; chaperons ; waterlogging ; water deficit ; photoinhibition ; selenium ; wheat ; Vigna vexillata ; mechanism ; grain protein content ; salinity ; nickel ; poaceae ; genome-wide association mapping ; nickel hyper-accumulation ; cell death ; mediterranean area ; ferroportin ; high salinity stress ; low nitrogen stress ; legume ; drought ; RNA-Seq ; histidine
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  • 10
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    Analytical Technology in Nutrition Analysis (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2024-04-05
    Description: Due to increasing global food needs as a result of population growth, the use of new food sources has gained interest in the last decade. However, the inclusion of new foods in our diet, as well as the increased interest of the population in consuming foods with better nutritional properties, has increased the need for adequate food analytical methods. This monographic issue presents innovative methods of chemical analysis of foods, as well as the nutritional and chemical characterization of foods whose consumption is expected to increase worldwide in the coming years.
    Keywords: QH301-705.5 ; Q1-390 ; TX341-641 ; blanching ; n/a ; acrylamide ; thickness ; seaweeds ; N-carbamylglutamate ; Chlorophyceae ; EPA+DHA ; hydrolysates ; Phaeophyceae ; carbohydrates ; scanning electron microscopy ; antioxidant ; scorpion (Buthus martensii Karsch) protein ; Gracilaria ; animal products ; milk ; prebiotic ; extraction ; functional properties ; refined commercial salmon oil ; HPLC-MS/MS ; total FA yield ; avocado oil ; n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) concentration ; DHA ; alcalase ; antioxidants compounds ; flavourzyme ; phenolic compounds ; UPLC-MSE ; oil extraction ; frying time ; response surface methodology ; fatty acid profile ; response surface methodology (RSM) ; Amazonian fruits ; water holding capacity ; phenolic acids ; amaranth protein ; temperature ; feeds ; multiple response optimization ; polysaccharides ; fatty acids ; Artemisia argyi leaves ; seaweed ; Rhodophyceae ; process variable maximization ; bioactive peptides ; vitamins ; EPA ; desirability function ; ultrasonic extraction ; bioactive compounds ; crisps ; deep eutectic solvents ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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