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  • 1
    Publication Date: 2014-03-10
    Description: Malaysia is free from several destructive and widespread natural disasters but frequently affected by floods, which caused massive flood damage. In 2006 and 2007, an extreme rainfall occured in many parts of Peninsular Malaysia, which caused severe flooding in several major cities. Kota Tinggi was chosen as study area as it is one the seriously affected area in Johor state. The aim of this study is to estimate potential flood damage to physical elements in Kota Tinggi. The flood damage map contains both qualitative and quantitative information which corresponds to the consequences of flooding. This study only focuses on physical elements. Three different damage functions were adopted to calculate the potential flood damage and flood depth is considered as the main parameter. The adopted functions are United States, the Netherlands and Malaysia. The estimated flood damage for housing using United States, the Netherlands and Malaysia was RM 350/m 2 RM 200/m 2 a...
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
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  • 2
    Publication Date: 2016-01-07
    Description: Cancer therapy largely depends on chemotherapeutic agents that generate DNA lesions. However, our understanding of the nature of the resulting lesions as well as the mutational profiles of these chemotherapeutic agents is limited. Among these lesions, DNA interstrand crosslinks are among the more toxic types of DNA damage. Here, we have characterized the mutational spectrum of the commonly used DNA interstrand crosslinking agent mitomycin C (MMC). Using a combination of genetic mapping, whole genome sequencing, and genomic analysis, we have identified and confirmed several genomic lesions linked to MMC-induced DNA damage in Caenorhabditis elegans . Our data indicate that MMC predominantly causes deletions, with a 5'-CpG-3' sequence context prevalent in the deleted regions of DNA. Furthermore, we identified microhomology flanking the deletion junctions, indicative of DNA repair via nonhomologous end joining. Based on these results, we propose a general repair mechanism that is likely to be involved in the biological response to this highly toxic agent. In conclusion, the systematic study we have described provides insight into potential sequence specificity of MMC with DNA.
    Electronic ISSN: 2160-1836
    Topics: Biology
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