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  • thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology  (5)
  • AERODYNAMICS
  • Humans
  • Life and Medical Sciences
  • Lunar and Planetary Science and Exploration
  • Mice
  • SPACE SCIENCES
  • Frontiers Media SA  (5)
  • 1
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: Echolocation has evolved in different groups of animals, from bats and cetaceans to birds and humans, and enables localization and tracking of objects in a dynamic environment, where light levels may be very low or absent. Nature has shaped echolocation, an active sense that engages audiomotor feedback systems, which operates in diverse environments and situations. Echolocation production and perception vary across species, and signals are often adapted to the environment and task. In the last several decades, researchers have been studying the echolocation behavior of animals, both in the air and underwater, using different methodologies and perspectives. The result of these studies has led to rich knowledge on sound production mechanisms, directionality of the sound beam, signal design, echo reception and perception. Active control over echolocation signal production and the mechanisms for echo processing ultimately provide animals with an echoic scene or image of their surroundings. Sonar signal features directly influence the information available for the echolocating animal to perceive images of its environment. In many echolocating animals, the information processed through echoes elicits a reaction in motor systems, including adjustments in subsequent echolocation signals. We are interested in understanding how echolocating animals deal with different environments (e.g. clutter, light levels), tasks, distance to targets or objects, different prey types or other food sources, presence of conspecifics or certain predators, ambient and anthropogenic noise. In recent years, some researchers have presented new data on the origins of echolocation, which can provide a hint of its evolution. Theoreticians have addressed several issues that bear on echolocation systems, such as frequency or time resolution, target localization and beam-forming mechanisms. In this Research Topic we compiled recent work that elucidates how echolocation – from sound production, through echolocation signals to perception- has been shaped by nature functioning in different environments and situations. We strongly encouraged comparative approaches that would deepen our understanding of the processes comprising this active sense.
    Keywords: QP1-981 ; Q1-390 ; bats ; Biosonar ; Humans ; marine mammals ; sensory biology ; Birds ; Behavior ; Communication ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 2
    Publication Date: 2024-03-31
    Description: Development of powerful new high- throughput technologies for probing the transcriptome, proteome and metabolome is driving the rapid acquisition of information on the function of molecular systems. The importance of these achievements cannot be understated - they have transformed the nature of both biology and medicine. Despite this dramatic progress, one of the greatest challenges that continues to confront modern biology is to understand how behavior at the level of genome, proteome and metabolome determines physiological function at the level of cell, tissue and organ in both health and disease. Because of the inherent complexity of biological systems, the development, analysis, and validation of integrative computational models based directly on experimental data is necessary to achieve this understanding. This approach, known as systems biology, integrates computational and experimental approaches through iterative development of mathematical models and experimental validation and testing. The combination of these approaches allows for a mechanistic understanding of the function of complex biological systems in health and their dysfunction in disease. The National Heart, Lung, and Blood Institute (NHLBI) has recognized the importance of the systems biology approach for understanding normal physiology and perturbations associated with heart, lung, blood, and sleep diseases and disorders. In 2006, NHLBI announced the Exploratory Program in Systems Biology, followed in 2010 by the NHLBI Systems Biology Collaborations. The goal of these programs is to support collaborative teams of investigators in using experimental and computational strategies to integrate the component parts of biological networks and pathways into computational models that are based firmly on and validated using experimental data. These validated models are then applied to gain insights into the mechanisms of altered system function in disease, to generate novel hypotheses regarding these mechanisms that can be tested experimentally, and to then use the results of experiments to refine the models. The purpose of this Research Topic is to present the range of innovative, new approaches being developed by investigators working in areas of systems biology that couple experimental and modeling studies to understand the cause and possible treatment of heart, lung, blood and sleep diseases and disorders. This Research Topic will be of great interest to the cardiovascular research community as well as to the general community of systems biologists.
    Keywords: QP1-981 ; TP248.13-248.65 ; TA1-2040 ; Q1-390 ; sepsis models ; immune system models ; micro-RNA networks ; pulmonary models ; Computational Medicine ; cardiac models ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 3
    Publication Date: 2024-03-31
    Description: Ca2+ is a key second messenger in the intricate workings of the heart. In cardiac myocytes, Ca2+ signaling controls or modulates electrophysiological function, excitation-contraction coupling, contractile function, energy balance, cell death, and gene transcription. Thus, diverse Ca2+-dependent regulatory processes occur simultaneously within a cell. Yet, distinct signals can be resolved by local Ca2+ sensitive protein complexes and differential Ca2+ signal integration. In addition to its importance to normal cardiac function, such regulation is also crucial in disease conditions. Ca2+ is likely involved in ectopic cardiac rhythms in both atrial and ventricular tissues through generating triggered activity often appearing as delayed afterdepolarisations, particularly following cellular Ca overloading. Recent studies also implicate Ca2+ in Na+ channel expression and properties with consequences for conduction velocity and therefore arrhythmic substrate. At the cellular level, such regulation involves control of the activity of membrane ion channels and Ca2+ handling proteins. These in turn involve multiple extra- and intracellular signaling pathways. This e-book assembles review and original articles from experts in this field. It summarises major recent progress bearing on roles of Ca2+ in cardiac electrophysiological function encompassing both normal and abnormal cardiac function. These extend from physiological roles of Ca2+ signaling in pacemaker function, in particular generation of sino-atrial pacemaker potentials, to pathological roles of abnormal Ca2+ signaling in both atrial and ventricular arrhythmogenesis. It also seeks to bridge the gap between advances in basic science and development of new therapies.
    Keywords: QP1-981 ; Q1-390 ; Heart ; Pak1 ; SA node ; STIM1 ; TRPC ; Ca2+ ; Orai1 ; PP2A ; voltage gated Ca2+ channels ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 4
    Publication Date: 2024-03-31
    Description: In 1960, the 9th Annual International Stoke Mandeville Games were supported, for the first time, by the Italian Olympic Committee. Taking place six days after the Closing Ceremony of the XVII Olympic Games, the paralympic games for disabled athletes were born. From Roma in 1960 to London in 2012, the Paralympic Games grew in terms of athletes’ number from 400 to 4,237, and now brings together more than 164 nations (Perret, 2015). The word “Paralympic” derives from the Greek preposition “para” (beside or alongside) and the word “Olympic”. Paralympics want to be the parallel Games to the Olympics and illustrate how the two movements exist side-by-side (Paralympics – History of the Movement, 2016). Now taking place after the Olympics Games, the Paralympic Games are the pinnacle of the career of athletes with physical impairments and have become the second largest sport event in the world (Perret, 2015; Paralympics – History of the Movement, 2016; Gold and Gold, 2011). The first statement of the vision of the International Paralympic Committee (IPC), i.e. “to create the conditions for athlete empowerment through self-determination” (Paralympics – History of the Movement, 2016; International Paralympic Committee, 2016), shows the importance of the place of the athlete with an impairment at the heart of the Paralympic Movement. The ultimate aim of the IPC is « to enable Paralympic athletes to achieve sporting excellence and inspire and excite the world. » (International Paralympic Committee, 2016). The performance level of athletes with an impairment improved to a point that, in the present days, sport news and world sport movements focus on the potential advantage of artificial limbs among athletes with amputations and their integration in able-bodied competitions (Burkett, 2010). However, they do not represent the totality of athletes with an impairment at the Paralympic Games. Athletes with other physical impairments (visual deficit, spinal cord injury, cerebral palsy or else) are eligible to compete. These impairments induce typical functional and physiological (e.g., cardiovascular, thermoregulatory) responses to exercise. For example, spinal cord injury (athletes with tetraplegia or paraplegia) causes thermoregulatory impairment (Goosey-Tolfrey et al., 2008) and individuals with cerebral palsy have also demonstrated higher thermal and metabolic strain than matched controls during treadmill walking in the heat (Maltais et al., 2004). Thus, hyperthermia among these athletes with an impairment alters their performance compared to their Olympic counterparts (Bhambhani, 2002). Mechanical performance analysis, the description of physiological responses according to the functional impairment or else the response to training and the relationship between laboratory and field testing responses are different parts of a package introduced here to address the aim of the IPC: to enable Paralympic athletes to achieve sporting excellence (Paralympics – History of the Movement, 2016; International Paralympic Committee, 2016).
    Keywords: QP1-981 ; Q1-390 ; Disability ; heat ; performance ; Athletes ; Paralympics ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 5
    Publication Date: 2024-03-31
    Description: Physiology in extreme conditions can reveal important reactions of the human body, which help our assessment of limits emerging under healthy conditions and critical signals of transition toward disease. While many mechanisms could simply be associated with adaptations, others refer to unexpected reactions in response to internal stimuli and/or external abrupt changes.
    Keywords: QP1-981 ; Q1-390 ; extreme environments ; homeostasis ; sports ; heart disease ; adaptation ; underwater ; psychiatry ; space ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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