Publication Date:
2014-03-29
Description:
Article The IRE1α-XBP1 signalling pathway is part of the ER stress response but has also been linked to glucose and lipid metabolism. Here the authors show that IRE1α in the liver acts as a nutrient-sensor, regulating the metabolic adaptation to fasting and a ketogenic diet by inducing PPARα expression. Nature Communications doi: 10.1038/ncomms4528 Authors: Mengle Shao, Bo Shan, Yang Liu, Yiping Deng, Cheng Yan, Ying Wu, Ting Mao, Yifu Qiu, Yubo Zhou, Shan Jiang, Weiping Jia, Jingya Li, Jia Li, Liangyou Rui, Liu Yang, Yong Liu
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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