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  • 1
    Call number: IASS 16.90589
    Description / Table of Contents: Introduction / Elena Conde and Sara Iglesias Sánchez -- Why and how to study Arctic law? / Timo Koivurova -- Arctic outer continental shelf / Elena Conde and Zhaklin Valerieva Yaneva -- The Northwest Passage and Northern Sea Route : sovereignty and responsibilities / Suzanna LaLonde -- The position of the European Union on the Svalbard waters / Marta Sobrido -- Stewardship sovereignty, sustainable developmnet and the protection of the Arctic marine environment : injecting environmental values in international sovereignty law / Sven G. Kaufmann -- Legal status and environmental protection of the Arctic sea ice : European perspectives / Claudia Cinelli -- The Arctic Council at twenty : cooperation between governments in the global Arctic / Christoph Humrich -- Geopolitics, governance and Arctic fisheries politics / Olav Schram Stokke -- The Arctic development : new navigational routes and maritime governance / Marta Iglesias Berlanga -- Arctic indigenous peoples at European courts : issues concerning their effective judical protection at the CJEU and the ECtHR / Sara Iglesias Sánchez -- Environment challenges for Arctic peoples / Soledad Torrecuadrada García-Lozano and Rosa Maria Fernandez Egea -- Climate change and human mobility : the national and international approach to native community relocation in the Arctic / Nuria Arenas-Hidalgo -- Knowledge and natural resources : a crucial conection for local benefits and sustainable Arctic development / Rasmus Gjedssø Bertelsen and Jens Christian Svabo Justinussen -- EU-Greenland relations and sustainable development in the Arctic / Cécile Pelaudeix -- The effectiveness of current regulatory models of gas flaring in light of black carbon emissions reduction in the Arctic / Daria Shapovalova -- From cylinder to sphere : the impact of climate change in the Arctic beyond the Polar Circle / Ángel Gómez De Ágreda -- Security challenges in the Arctic / Rob Huebert -- Geopolitical dynamics in the Arctic : actors and global interests / Taisaku Ikeshima - Changing foreign policy roles in the changing Arctic / Michal Luszczuk -- The role(s) of China in the Arctic : regional governance and foreseeable challenges / Francois Perreault -- Chinese Arctic science diplomacy : an instrument for achieving the Chinese dream? / Rasmus Gjedssø Bertelsen, Li Xing, and Mette Højris Gregersen
    Type of Medium: Monograph available for loan
    Pages: ix, 464 Seiten
    ISBN: 9781472463258 (hbk) , 9781315584768 (ebook)
    Language: English
    Branch Library: RIFS Library
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  • 2
    Publication Date: 2020-01-22
    Electronic ISSN: 1664-302X
    Topics: Biology
    Published by Frontiers Media
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  • 3
    Publication Date: 2021-03-09
    Description: Fibroblast growth factor-23 (FGF)-23 is a phosphaturic hormone involved in mineral bone metabolism that helps control phosphate homeostasis and reduces 1,25-dihydroxyvitamin D synthesis. Recent data have highlighted the relevant direct FGF-23 effects on the myocardium, and high plasma levels of FGF-23 have been associated with adverse cardiovascular outcomes in humans, such as heart failure and arrhythmias. Therefore, FGF-23 has emerged as a novel biomarker of cardiovascular risk in the last decade. Indeed, experimental data suggest FGF-23 as a direct mediator of cardiac hypertrophy development, cardiac fibrosis and cardiac dysfunction via specific myocardial FGF receptor (FGFR) activation. Therefore, the FGF-23/FGFR pathway might be a suitable therapeutic target for reducing the deleterious effects of FGF-23 on the cardiovascular system. More research is needed to fully understand the intracellular FGF-23-dependent mechanisms, clarify the downstream pathways and identify which could be the most appropriate targets for better therapeutic intervention. This review updates the current knowledge on both clinical and experimental studies and highlights the evidence linking FGF-23 to cardiovascular events. The aim of this review is to establish the specific role of FGF-23 in the heart, its detrimental effects on cardiac tissue and the possible new therapeutic opportunities to block these effects.
    Electronic ISSN: 1664-042X
    Topics: Biology
    Published by Frontiers Media
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  • 4
    Publication Date: 2021-04-29
    Description: Genome editing with sequence-specific nucleases, such as clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), is revolutionizing crop improvement. Developing efficient genome-editing protocols for highly polyploid crops, including sugarcane (x = 10–13), remains challenging due to the high level of genetic redundancy in these plants. Here, we report the efficient multiallelic editing of magnesium chelatase subunit I (MgCh) in sugarcane. Magnesium chelatase is a key enzyme for chlorophyll biosynthesis. CRISPR/Cas9-mediated targeted co-mutagenesis of 49 copies/alleles of magnesium chelatase was confirmed via Sanger sequencing of cloned PCR amplicons. This resulted in severely reduced chlorophyll contents, which was scorable at the time of plant regeneration in the tissue culture. Heat treatment following the delivery of genome editing reagents elevated the editing frequency 2-fold and drastically promoted co-editing of multiple alleles, which proved necessary to create a phenotype that was visibly distinguishable from the wild type. Despite their yellow leaf color, the edited plants were established well in the soil and did not show noticeable growth retardation. This approach will facilitate the establishment of genome editing protocols for recalcitrant crops and support further optimization, including the evaluation of alternative RNA-guided nucleases to overcome the limitations of the protospacer adjacent motif (PAM) site or to develop novel delivery strategies for genome editing reagents.
    Electronic ISSN: 2673-3439
    Topics: Biology
    Published by Frontiers Media
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