Publikationsdatum:
2016-02-23
Beschreibung:
This communication is in response to the recent publication by Friebel K, Schönherr R, Kinne RW, Kunisch E. “Functional role of the KCa3.1 potassium channel in synovial fibroblasts from rheumatoid arthritis patients” J Cell Physiol. 2015 Jul;230(7):1677-88. Friebel et al . reported a regulatory role for the calcium-activated potassium channel KCa3.1 on fibroblast like synovial cells (FLS) and its pathologic significance in rheumatoid arthritis (RA) (1). More specifically the authors observed that KCa3.1 regulates proliferation of FLS and several other functions of FLS relevant to pannus formation in the synovial joints such as secretion of proinflammtory cytokines and metalloproteinase. This article is protected by copyright. All rights reserved
Digitale ISSN:
1097-4652
Thema:
Biologie
,
Medizin
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