Publication Date:
2014-12-21
Description:
Article Small molecules that inhibit α-synuclein misfolding may have potential in the treatment of Parkinson’s disease. Fonseca-Ornelas et al. show that several of these molecules fail to block misfolding in the presence of membrane vesicles, and reveal how phtalocyanine tetrasulfonate, in contrast, overcomes this effect. Nature Communications doi: 10.1038/ncomms6857 Authors: Luis Fonseca-Ornelas, Sybille E. Eisbach, Maria Paulat, Karin Giller, Claudio O. Fernández, Tiago F. Outeiro, Stefan Becker, Markus Zweckstetter
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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