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  • 1
    Call number: AWI G5-15-0026
    In: Developments in paleoenvironmental research
    Description / Table of Contents: Contents: Using Natural Archives to Track Sources and Long-Term Trends of Pollution: An Introduction / Jules M. Blais, Michael R. Rosen and John P. Smol. - The Influence of Hydrology on Lacustrine Sediment Contaminant Records / Michael R. Rosen. - The Stability of Metal Profiles in Freshwater and Marine Sediments / P. M. Outridge and F. Wang. - Calculating Rates and Dates and Interpreting Contaminant Profiles in Biomixed Sediments / Zou Zou A. Kuzyk, Robie W. Macdonald and Sophia C. Johannessen. - Contaminants in Marine Sedimentary Deposits from Coal Fly Ash During the Latest Permian Extinction / Hamed Sanei, Stephen E. Grasby and Benoit Beauchamp. - Lake Sediment Records of Preindustrial Metal Pollution / Colin A. Cooke and Richard Bindler. - Lacustrine Archives of Metals from Mining and Other Industrial Activities - A Geochemical Approach / John Boyle, Richard Chiverrell and Dan Schillereff. - Organic Pollutants in Sediment Core Archives / Jennifer B. Korosi, Wenhan Cheng and Jules M. Blais. - Environmental Archives of Contaminant Particles / Neil L. Rose and Meri Ruppel. - Tracking Long-range Atmospheric Transport of Contaminants in Arctic Regions Using Lake Sediments / Jane Kirk and Amber Gleason. - Tracking Long-Range Atmospheric Transport of Trace Metals, Polycyclic Aromatic Hydrocarbons, and Organohalogen Compounds Using Lake Sediments of Mountain Regions / Jordi Catalan. - Using Peat Records as Natural Archives of Past Atmospheric Metal Deposition / Sophia V. Hansson, Richard Bindler and François De Vleeschouwer. - Historical Contaminant Records from Sclerochronological Archives / Jessica Carilli, Branwen Williams, Bernd R. Schöne, Richard A. Krause and Stewart J. Fallon. - Contaminant Records in Ice Cores / Paolo Gabrielli and Paul Vallelonga. - Use of Catalogued Long-term Biological Collections and Samples for Determining Changes in Contaminant Exposure to Organisms / Linda M. Campbell and Paul E. Drevnick. - Tracking Contaminant Transport From Biovectors / Roland Kallenborn and Jules M. Blais. - Using Natural Archives to Track Sources and Long-Term Trends of Pollution: Some Final Thoughts and Suggestions for Future Directions / Jules M. Blais, Michael R. Rosen and John P. Smol. - Index.
    Description / Table of Contents: The human footprint on the global environment now touches every corner of the world. This book explores the myriad ways that environmental archives can be used to study the distribution and long-term trajectories of chemical contaminants. The volume first focuses on reviews that examine the integrity of the historic record, including factors related to hydrology, post-depositional diffusion, and mixing processes. This is followed by a series of chapters dealing with the diverse archives and methodologies available for long-term studies of environmental pollution, such as the use of sediments, ice cores, sclerochronology, and museum specimens.
    Type of Medium: Monograph available for loan
    Pages: XVI, 509 p.
    ISBN: 9789401795401
    Series Statement: Developments in paleoenvironmental research 18
    Branch Library: AWI Library
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archiv der Mathematik 41 (1983), S. 143-146 
    ISSN: 1420-8938
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Rho-family GTP-hydrolysing proteins (GTPases), Cdc42, Rac and Rho, act as molecular switches in signalling pathways that regulate cytoskeletal architecture, gene expression and progression of the cell cycle. Cdc42 and Rac transmit many signals through GTP-dependent binding to effector proteins ...
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Rho GDP-dissociation inhibitors (GDIs) negatively regulate Rho-family GTPases,. The inhibitory activity of GDI derives both from an ability to bind the carboxy-terminal isoprene of Rho family members and extract them from membranes,, and from inhibition of GTPase cycling between the GTP- ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archiv der Mathematik 24 (1973), S. 287-296 
    ISSN: 1420-8938
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Mathematische Annalen 256 (1981), S. 549-560 
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Inventiones mathematicae 133 (1998), S. 43-67 
    ISSN: 1432-1297
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract. Nagao has recently given a conjectural limit formula for the rank of an elliptic surface E in terms of a weighted average of fibral Frobenius trace values. We show that Tate's conjecture on the order of vanishing of L 2(E,s) essentially implies Nagao's formula; in particular, we prove Nagao's formula for rational elliptic surfaces. In the case that E is a twist, we reduce Nagao's and Tate's conjectures to the case of products of curves, and we verify the conjectures for many new classes of elliptic surfaces of Kodaira dimension 0 and 1.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 82 (1988), S. 5-11 
    ISSN: 1573-4919
    Keywords: catecholamines ; cultured heart cells ; Purkinje fibers ; pertussis toxin ; lymphocytes ; beta receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary Guanine nucleotide binding proteins were examined for their influence in developmental and adaptive models of adrenergic actions in the heart. In primary cultures of rat cardiac myocytes, the positive chronotropic response to the alpha-agonist, phenylephrine, changes to negative when these cells are grown with and innervated by sympathetic nerves from the paravertebral chain. Innervated cells have significantly more G protein, as determined by the ADP-ribosylation reaction catalyzed by pertussis toxin, which is linked functionally to the negative chronotropic response. Adult canine Purkinje fibers that respond to phenylephrine with a decrease in automaticity are also linked biochemically and functionally to a G protein that serves as a pertussis toxin substrate. Fibers that increase in automaticity after exposure to phenylephrine, either under control conditions (a minority of fibers) or after prior exposure to pertussis toxin (a majority of fibers), have markedly reduced levels of G. A G protein was also shown to be important in the blunted adrenergic responsiveness that characterizes congestive heart failure in human subjects. In this model, the receptor complex is beta-adrenergic and the involved G protein is a cholera toxin substrate. Gs is reduced in the lymphocytes of patients with congestive heart failure and increases toward normal after successful therapy. These observations highlight the important roles that G proteins have in adrenergic actions of the heart both with respect developmental and adaptive changes.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-5001
    Keywords: FKBP12 ; NMR detection ; sensitivity enhancement ; side chain–main chain hydrogen bonds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract We describe the direct observation of very weak side chain–main chain hydrogen bonding interactions in medium-size 13C/15N-labeled proteins with sensitivity-enhanced NMR spectroscopy. Specifically, the remote correlation between the hydrogen acceptor side chain carboxylate carbon 13CO2 δ of glutamate 54 and the hydrogen donor backbone amide 15N of methionine 49 in a 12 kDa protein, human FKBP12, is detected via the trans-hydrogen bond 3h J NCO2δ coupling by employing a novel sensitivity-enhanced HNCO-type experiment, CPD-HNCO. The 3h J NCO2δ coupling constant appears to be even smaller than the average value of backbone 3h J NC′ couplings, consistent with more extensive local dynamics in protein side chains.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-5001
    Keywords: (H)C(CO)NH-TOCSY ; Multidimensional NMR ; Deuteration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary A biosynthetic strategy has recently been developed for the production of 15N, 13C, 2H-labeled proteins using 1H3C-pyruvate as the sole carbon source and D2O as the solvent. The methyl groups of Ala, Val, Leu and Ile (γ2 only) remain highly protonated, while the remaining positions in the molecule are largely deuterated. An (H)C(CO)NH-TOCSY experiment is presented for the sequential assignment of the protonated methyl groups. A high-sensitivity spectrum is recorded on a 15N, 13C, 2H, 1H3C-labeled SH2 domain at 3°C (correlation time 18.8 ns), demonstrating the utility of the method for proteins in the 30–40 kDa molecular weight range.
    Type of Medium: Electronic Resource
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