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  • Broadband NIRS, Hypothermia, Systems biology  (1)
  • thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR7 Second World War  (1)
  • Springer Nature  (2)
  • Copernicus
  • Nature Publishing Group
  • 1
    Publication Date: 2024-04-05
    Description: Hypoxic ischemic encephalopathy (HIE) is a significant cause of death and neurological disability in newborns. Therapeutic hypothermia at 33.5 °C is one of the most common treatments in HIE and generally improves outcome; however 45–55% of injuries still result in death or severe neurodevelopmental disability. We have developed a systems biology model of cerebral oxygen transport and metabolism to model the impact of hypothermia on the piglet brain (the neonatal preclinical animal model) tissue physiology. This computational model is an extension of the BrainSignals model of the adult brain. The model predicts that during hypothermia there is a 5.1% decrease in cerebral metabolism, 1.1% decrease in blood flow and 2.3% increase in cerebral tissue oxygenation saturation. The model can be used to simulate effects of hypothermia on the brain and to help interpret bedside recordings.
    Keywords: Broadband NIRS, Hypothermia, Systems biology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 2
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    Springer Nature
    Publication Date: 2024-04-04
    Description: Horrified by the Holocaust, social psychologist Stanley Milgram wondered if he could recreate the Holocaust in the laboratory setting. Unabated for more than half a century, his (in)famous results have continued to intrigue scholars. Based on unpublished archival data from Milgram’s personal collection, volume one of this two-volume set introduces readers to a behind the scenes account showing how during Milgram’s unpublished pilot studies he step-by-step invented his official experimental procedure—how he gradually learnt to transform most ordinary people into willing inflictors of harm. The open access volume two then illustrates how certain innovators within the Nazi regime used the very same Milgram-like learning techniques that with increasing effectiveness gradually enabled them to also transform most ordinary people into increasingly capable executioners of other men, women, and children. Volume two effectively attempts to capture how step-by-step these Nazi innovators attempted to transform the Führer’s wish of a Jewish-free Europe into a frightening reality. By the books’ end the reader will gain an insight into how the seemingly undoable can become increasingly doable.
    Keywords: Psychology ; Personality ; Social psychology ; Psychology ; World War, 1939-1945 ; Psychology—Methodology ; Psychological measurement ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR7 Second World War ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWL Modern warfare ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBL c 1940 to c 1949::3MPBLB c 1938 to c 1946 (World War Two period) ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMB Psychological methodology ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMS Psychology: the self, ego, identity, personality ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDX History of science
    Language: English
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