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  • 1
    ISSN: 0935-6304
    Keywords: Capillary gas chromatography ; Liquid chromatography ; Mass spectrometry ; MO-TMS derivatization ; Corticosteroids ; Metabolism ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Adult male volunteers were administered orally 10 mg of the espective drug. Urine samples were investigated by micro-column liquid chromatography and capillary gas chromatography combined with on-line mass spectrometry. The former technique was found to be usable for the detection of these drugs. The latter method appeared to be superior in terms of sensitivity and for metabolism studies. The major excretion products of dexamethasone were identified as isomeric 6-hydroxy metabolites. Dexamethasone as such and its 20-hydroxy metabolite were found in minor quantities. Unlike dexamethasone, triamcinolone is excreted largely unchanged from the human body. Two metabolites were identified as 11-keto and 4,5-dihydrotriamcinolone. With the gas chromatography methods developed, abuse of these drugs can be detected up to 24 h after administration of a 5 mg single dose.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 4 (1990), S. 163-172 
    ISSN: 0268-2605
    Keywords: Organopolysilanes ; organopolysiloxanes ; photoinitiation ; vulcanization ; thin films ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The organopolysilanes Me(Me2Si)nMe (n = 4-6), (Me2Si)6 and (Me3Si)2SiMePh are found to be effective photoinitiators for the polymerization of vinyl-containing siloxane rubbers. The trisilanes Me(ME2Si)3Me and Me3SiSiMe2SiMe2Ph are slightly effective, while phenyldisilanes do not exhibit initiation activity in the process of photocuring. Polydimethylsiloxanes are cured at a slower rate under the same conditions than vinylcontaining derivatives. Two mechanisms of crosslinking are proposed: silylene-silirane-silanol and silylene-hydride-silanol.
    Additional Material: 1 Tab.
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  • 3
    Publication Date: 2012-11-01
    Description: The Arctic has featured the strongest surface warming over the globe during the recent decades, and the temperature increase has been accompanied by a rapid decline in sea ice extent. However, little is known about Arctic sea ice change during the early twentieth century warming (ETCW) during 1920–1940, also a period of a strong surface warming, both globally and in the Arctic. Here, we investigate the sensitivity of Arctic winter surface air temperature (SAT) to sea ice during 1875–2008 by means of simulations with an atmospheric general circulation model (AGCM) forced by estimates of the observed sea surface temperature (SST) and sea ice concentration. The Arctic warming trend since the 1960s is very well reproduced by the model. In contrast, ETCW in the Arctic is hardly captured. This is consistent with the fact that the sea ice extent in the forcing data does not strongly vary during ETCW. AGCM simulations with observed SST but fixed sea ice reveal a strong dependence of winter SAT on sea ice extent. In particular, the warming during the recent decades is strongly underestimated by the model, if the sea ice extent does not decline and varies only seasonally. This suggests that a significant reduction of winter Arctic sea ice extent may have also accompanied the early twentieth century warming, pointing toward an important link between anomalous sea ice extent and Arctic surface temperature variability.
    Print ISSN: 1994-0416
    Electronic ISSN: 1994-0424
    Topics: Geography , Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 4
    Publication Date: 2015-02-20
    Description: The shrinking Arctic sea ice cover observed during the last decades is probably the clearest manifestation of ongoing climate change. While climate models in general reproduce the sea ice retreat in the Arctic during the 20th century and simulate further sea ice area loss during the 21st century in response to anthropogenic forcing, the models suffer from large biases and the model results exhibit considerable spread. The last generation of climate models from World Climate Research Programme Coupled Model Intercomparison Project Phase 5 (CMIP5), when compared to the previous CMIP3 model ensemble and considering the whole Arctic, were found to be more consistent with the observed changes in sea ice extent during the recent decades. Some CMIP5 models project strongly accelerated (non-linear) sea ice loss during the first half of the 21st century. Here, complementary to previous studies, we compare results from CMIP3 and CMIP5 with respect to regional Arctic sea ice change. We focus on September and March sea ice. Sea ice area (SIA) variability, sea ice concentration (SIC) variability, and characteristics of the SIA seasonal cycle and interannual variability have been analysed for the whole Arctic, termed Entire Arctic, Central Arctic and Barents Sea. Further, the sensitivity of SIA changes to changes in Northern Hemisphere (NH) averaged temperature is investigated and several important dynamical links between SIA and natural climate variability involving the Atlantic Meridional Overturning Circulation (AMOC), North Atlantic Oscillation (NAO) and sea level pressure gradient (SLPG) in the western Barents Sea opening serving as an index of oceanic inflow to the Barents Sea are studied. The CMIP3 and CMIP5 models not only simulate a coherent decline of the Arctic SIA but also depict consistent changes in the SIA seasonal cycle and in the aforementioned dynamical links. The spatial patterns of SIC variability improve in the CMIP5 ensemble, particularly in summer. Both CMIP ensembles depict a significant link between the SIA and NH temperature changes. Our analysis suggests that, on average, the sensitivity of SIA to external forcing is enhanced in the CMIP5 models. The Arctic SIA variability response to anthropogenic forcing is different in CMIP3 and CMIP5. While the CMIP3 models simulate increased variability in March and September, the CMIP5 ensemble shows the opposite tendency. A noticeable improvement in the simulation of summer SIA by the CMIP5 models is often accompanied by worse results for winter SIA characteristics. The relation between SIA and mean AMOC changes is opposite in September and March, with March SIA changes being positively correlated with AMOC slowing. Finally, both CMIP ensembles demonstrate an ability to capture, at least qualitatively, important dynamical links of SIA to decadal variability of the AMOC, NAO and SLPG. SIA in the Barents Sea is strongly overestimated by the majority of the CMIP3 and CMIP5 models, and projected SIA changes are characterized by a large spread giving rise to high uncertainty.
    Print ISSN: 1994-0432
    Electronic ISSN: 1994-0440
    Topics: Geography , Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 5
    Publication Date: 2012-12-19
    Description: The strongest manifestation of global warming is observed in the Arctic. The warming in the Arctic during the recent decades is about twice as strong as in the global average and has been accompanied by a summer sea ice decline that is very likely unprecedented during the last millennium. Here, Arctic sea ice variability is analyzed in the ensemble of CMIP3 models. Complementary to several previous studies, we focus on regional aspects, in particular on the Barents Sea. We also investigate the changes in the seasonal cycle and interannual variability. In all regions, the models predict a reduction in sea ice area and sea ice volume during 1900–2100. Toward the end of the 21st century, the models simulate higher sea ice area variability in September than in March, whereas the variability in the preindustrial control runs is higher in March. Furthermore, the amplitude and phase of the sea ice seasonal cycle change in response to enhanced greenhouse warming. The amplitude of the sea ice area seasonal cycle increases due to the very strong sea ice area decline in September. The seasonal cycle amplitude of the sea ice volume decreases due to the stronger reduction of sea ice volume in March. Multi-model mean estimates for the late 20th century are comparable with observational data only for the entire Arctic and the Central Arctic. In the Barents Sea, differences between the multi-model mean and the observational data are more pronounced. Regional sea ice sensitivity to Northern Hemisphere average surface warming has been investigated.
    Print ISSN: 1994-0432
    Electronic ISSN: 1994-0440
    Topics: Geography , Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 6
    Publication Date: 2012-06-12
    Description: The Arctic featured the strongest surface warming over the globe during the recent decades, and the temperature increase was accompanied by a rapid decline in sea ice extent. However, little is known about Arctic sea ice change during the Early Twentieth Century Warming (ETCW) during 1920–1940, also a period of a strong surface warming, both globally and in the Arctic. Here, we investigate the sensitivity of Arctic winter surface air temperature (SAT) to sea ice during 1875–2008 by means of simulations with an atmospheric general circulation model (AGCM) forced by estimates of the observed sea surface temperature (SST) and sea ice concentration. The Arctic warming trend since the 1960s is very well reproduced by the model. In contrast, ETCW in the Arctic is hardly captured. This is consistent with the fact that the sea ice extent in the forcing data does not strongly vary during ETCW. AGCM simulations with observed SST but fixed sea ice reveal a strong dependence of winter SAT on sea ice extent. In particular, the warming during the recent decades is strongly underestimated by the model, if the sea ice extent does not decline and varies only seasonally. This suggests that a significant reduction of Arctic sea ice extent may have also accompanied the Early Twentieth Century Warming, pointing toward an important link between anomalous sea ice extent and Arctic surface temperature variability.
    Print ISSN: 1994-0432
    Electronic ISSN: 1994-0440
    Topics: Geography , Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 7
    Publication Date: 2002-04-30
    Description: Magnetic reconnection is an important process providing a fast conversion of magnetic energy into thermal and kinetic plasma energy. In this concern, a key problem is that of the resistive diffusion region where the reconnection process is initiated. In this paper, the diffusion region is associated with a nonuniform conductivity localized to a small region. The nonsteady resistive incompressible MHD equations are solved numerically for the case of symmetric reconnection of antiparallel magnetic fields. A Petschek type steady-state solution is obtained as a result of time relaxation of the reconnection layer structure from an arbitrary initial stage. The structure of the diffusion region is studied for various ratios of maximum and minimum values of the plasma resistivity. The effective length of the diffusion region and the reconnection rate are determined as functions of the length scale and the maximum of the resistivity. For sufficiently small length scale of the resistivity, the reconnection rate is shown to be consistent with Petschek's formula. By increasing the resistivity length scale and decreasing the resistivity maximum, the reconnection layer tends to be wider, and correspondingly, the reconnection rate tends to be more consistent with that of the Parker-Sweet regime.
    Print ISSN: 1023-5809
    Electronic ISSN: 1607-7946
    Topics: Geosciences , Physics
    Published by Copernicus on behalf of European Geosciences Union.
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  • 8
    Publication Date: 2002-04-30
    Description: Variations of the plasma pressure in a magnetic flux tube can produce MHD waves evolving into shocks. In the case of a low plasma beta, plasma pressure pulses in the magnetic flux tube generate MHD slow shocks propagating along the tube. For converging magnetic field lines, such as in a dipole magnetic field, the cross section of the magnetic flux tube decreases enormously with increasing magnetic field strength. In such a case, the propagation of MHD waves along magnetic flux tubes is rather different from that in the case of uniform magnetic fields. In this paper, the propagation of MHD slow shocks is studied numerically using the ideal MHD equations in an approximation suitable for a thin magnetic flux tube with a low plasma beta. The results obtained in the numerical study show that the jumps in the plasma parameters at the MHD slow shock increase greatly while the shock is propagating in the narrowing magnetic flux tube. The results are applied to the case of the interaction between Jupiter and its satellite Io, the latter being considered as a source of plasma pressure pulses.
    Print ISSN: 1023-5809
    Electronic ISSN: 1607-7946
    Topics: Geosciences , Physics
    Published by Copernicus on behalf of European Geosciences Union.
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  • 9
    Publication Date: 2002-08-31
    Description: In the MHD description of plasma phenomena the concept of magnetic helicity turns out to be very useful. We present here an example of introducing Euler potentials into a topological MHD soliton which has non-trivial helicity. The MHD soliton solution (Kamchatnov, 1982) is based on the Hopf invariant of the mapping of a 3-D sphere into a 2-D sphere; it can have arbitrary helicity depending on control parameters. It is shown how to define Euler potentials globally. The singular curve of the Euler potential plays the key role in computing helicity. With the introduction of Euler potentials, the helicity can be calculated as an integral over the surface bounded by this singular curve. A special programme for visualization is worked out. Helicity coordinates are introduced which can be useful for numerical simulations where helicity control is needed.
    Print ISSN: 1023-5809
    Electronic ISSN: 1607-7946
    Topics: Geosciences , Physics
    Published by Copernicus on behalf of European Geosciences Union.
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  • 10
    Publication Date: 2015-06-15
    Description: An approach is proposed to assess hydrological simulation uncertainty originating from internal atmospheric variability. The latter is one of three major factors contributing to uncertainty of simulated climate change projections (along with so-called "forcing" and "climate model" uncertainties). Importantly, the role of internal atmospheric variability is most visible over spatio-temporal scales of water management in large river basins. Internal atmospheric variability is represented by large ensemble simulations (45 members) with the ECHAM5 atmospheric general circulation model. Ensemble simulations are performed using identical prescribed lower boundary conditions (observed sea surface temperature, SST, and sea ice concentration, SIC, for 1979–2012) and constant external forcing parameters but different initial conditions of the atmosphere. The ensemble of bias-corrected ECHAM5 outputs and ensemble averaged ECHAM5 output are used as a distributed input for the ECOMAG and SWAP hydrological models. The corresponding ensembles of runoff hydrographs are calculated for two large rivers of the Arctic basin: the Lena and Northern Dvina rivers. A number of runoff statistics including the mean and the standard deviation of annual, monthly and daily runoff, as well as annual runoff trend, are assessed. Uncertainties of runoff statistics caused by internal atmospheric variability are estimated. It is found that uncertainty of the mean and the standard deviation of runoff has a significant seasonal dependence on the maximum during the periods of spring–summer snowmelt and summer–autumn rainfall floods. Noticeable nonlinearity of the hydrological models' results in the ensemble ECHAM5 output is found most strongly expressed for the Northern Dvina River basin. It is shown that the averaging over ensemble members effectively filters the stochastic term related to internal atmospheric variability. Simulated discharge trends are close to normally distributed around the ensemble mean value, which fits well to empirical estimates and, for the Lena River, indicates that a considerable portion of the observed trend can be externally driven.
    Print ISSN: 1027-5606
    Electronic ISSN: 1607-7938
    Topics: Geography , Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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